Results 111 to 120 of about 2,419,951 (303)
Great Smoky Mountains and the National Park
This article “The Great Smoky Mountains and the National Park” was written by Horace Kephart and looks to have been reprinted by the National Park Service.
Kephart, Horace, 1862-1931;
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Ridgefield Park Environmental Resource Inventory Addendum I: Water Sampling Results
This addendum is a summary of results for the 2000-2001 school year of water sampling performed by staff and students of the Ridgefield Park school system. Test types and results are listed in table form.Prepared for the Village of Ridgefield Park with a
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Park dedication: traffic control
This confidential memorandum provides instructions to deal with traffic during the dedication of the Great Smoky Mountains National Park. The dedication took place on Labor Day, September 2, 1940.
Eakin, J. Ross, 1879-1946
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We show that the spacing distribution between parked cars can be obtained as a solution of certain linear distributional fixed point equation. The results are compared with the data measured on the streets of Hradec Kralove. We also discuss a relation of this results to the random matrix theory.
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Editorial: Appalachian National Park
In promoting a national park in the southern Appalachians, Chase Ambler wrote dozens of editorials and submitted them to newspapers and magazines throughout the east coast.
Ambler, Chase P., 1865-1932;
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