Results 71 to 80 of about 992,466 (266)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Parks and gardens in poetic reminiscences used to deliver philosophic ideas
Studia Humanitatis, 2017 The paper focuses on analyzing the image of parks and gardens that helps to deliver philosophic ideas in fiction. The research bases on the novel “The French Lieutenant’s Woman” by John Fowles.
Drozdova Maria Sergeevna
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
INFLUENCING FACTORS ON PERFORMANCE OF SOCIAL BEHAVIOR SETTINGS AT PARKS AND GREEN SPACES OF TABRIZ [PDF]
Journal of Urban and Regional Analysis, 2018 Parks and green spaces are significant areas that are necessary to reduce citizens’ mental and moral pressures more than ever. So, as for the importance of parks and urban green spaces, consideration of influencing factors on performance of these areas ...
Ali Majnouni TOUTAKHANE
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
I parchi, strumenti moderni per la gestione integrata del territorio
Ri-vista: Ricerche per la Progettazione del Paesaggio, 2015 The “peculiarity” of the park: Gambino research for the interpretation of the international framework and its comparison with the Italian background. Theoretical and practical contributions on critical issues of the national context: the Protected Area ...
Giampiero Sammuri
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Dal parco al progetto di territorio: evoluzione o discontinuità?
Ri-vista: Ricerche per la Progettazione del Paesaggio, 2015 In celebrating Roberto Gambino, I underline the ethical role of his professional activity, systematically oriented to experiment scientific advancements of town planning towards territorial and landscape quality in fostering public interest.
Alberto Magnaghi
doaj +1 more source