Results 61 to 70 of about 13,200 (261)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Economic Operation Strategy of an EV Parking Lot with Vehicle-to-Grid and Renewable Energy Integration

Energies, 2023
The economic operation of an electric vehicle (EV) parking lot under different cases are explored in the paper. The parking lot is equipped with EV charging stations with a vehicle-to-grid (V2G) function, renewable energy sources (RESs), and energy ...
Jiwen Qi, Li Li
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Research and Implementation of Automatic Fuzzy Garage Parking System Based on FPGA

MATEC Web of Conferences, 2016
Because of many common scenes of reverse parking in real life, this paper presents a fuzzy controller which accommodates front and back adjustment of vehicle’s body attitude, and based on chaotic-genetic arithmetic to optimize the membership function of ...
Wang Kaiyu, Yu Zongmin, Guan Sanghai, Yang Xing, Sheng Menglin, Tang Zhenan   +5 more
doaj   +1 more source

Prime parking functions on rooted trees [PDF]

Journal of Combinatorial Theory, Series A, 2019
For a labeled, rooted tree with edges oriented towards the root, we consider the vertices as parking spots and the edge orientation as a one-way street. Each driver, starting with her preferred parking spot, searches for and parks in the first unoccupied spot along the directed path to the root. If all $n$ drivers park, the sequence of spot preferences
Westin King, Catherine H. Yan
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Primeness of Generalized Parking Functions

The Electronic Journal of Combinatorics
Classical parking functions are a generalization of permutations that appear in many combinatorial structures. Prime parking functions are indecomposable components such that any classical parking function can be uniquely described as a direct sum of prime ones.
Sam Armon, Joanne Beckford, Dillon Hanson, Naomi Krawzik, Olya Mandelshtam, Lucy Martinez, Catherine Yan 0001   +6 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Tutte polynomials and G-parking functions

Advances in Applied Mathematics, 2010
Let $G$ be a connected graph with vertex set $\{0,1,2,...,n\}$. We allow $G$ to have multiple edges and loops. In this paper, we give a characterization of external activity by some parameters of $G$-parking functions. In particular, we give the definition of the bridge vertex of a $G$-parking function and obtain an expression of the Tutte polynomial ...
Hungyung Chang, Jun Ma 0017, Yeong-Nan Yeh   +2 more
openaire   +2 more sources