Results 21 to 30 of about 65,912 (274)

Detecting cognitive impairment in patients with Parkinson's disease using a brief cognitive screening tool: Addenbrooke's Cognitive Examination (ACE)

Dementia & Neuropsychologia
Detecting cognitive impairment in patients with Parkinson's disease is crucial for good clinical practice given the new therapeutic possibilities available.
Anabel Chade, María Roca, Teresa Torralva, Ezequiel Gleichgerrcht, Nicolás Fabbro, Gonzalo Gómez Arévalo, Oscar Gershanik, Facundo Manes   +7 more
doaj   +1 more source

Additional file 4: Table S2. of Guidelines for dementia or Parkinsonâ s disease with depression or anxiety: a systematic review

, 2016
Mean Domain Question Scores From AGREE II Evaluation. (DOCX 16 kb)
Goodarzi, Zahra, Mele, Bria, Selynne Guo, Hanson, Heather, Jette, Nathalie, Patten, Scott, Pringsheim, Tamara, Jayna Holroyd-Leduc   +7 more
openaire   +1 more source

Additional file 2: Table S1. of Guidelines for dementia or Parkinsonâ s disease with depression or anxiety: a systematic review

, 2016
Grey Literature Sources (n = 83). (DOCX 15 kb)
Goodarzi, Zahra, Mele, Bria, Guo, Selynne, Hanson, Heather, Jette, Nathalie, Patten, Scott, Pringsheim, Tamara, Holroyd-Leduc, Jayna   +7 more
openaire   +1 more source

Biomarkers in Parkinson’s disease: A state of the art review

Biomarkers in Neuropsychiatry, 2023
Biomarkers in Parkinson’s disease are widely researched in the field of neuropsychiatry. Though Parkinson’s disease is diagnosed clinically, biomarkers prove to be a promising means to identify disease in early stages, track disease progression, and ...
Kyla Y. Yamashita, Sweta Bhoopatiraju, Bret D. Silverglate, George T. Grossberg   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

From allegory to conceptualization, hypothesis and finally evidences: Alzheimer’s dementia, Parkinson's disease "gut–brain axis" and their preclinical phenotype

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Researchers are constantly trying to develop therapeutic targets in neurodegenerative disorders like Alzheimer's dementia and Parkinson's disease. Despite enormous endeavors, there are several unmet needs.
Souvik Dubey, Ritwik Ghosh, Mahua Jana Dubey, Samya Sengupta, Shambaditya Das   +4 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Assessment of genetic risk for improved clinical-neuropathological correlations

Acta Neuropathologica Communications, 2020
In the clinical diagnosis of dementia with Lewy bodies, distinction from Alzheimer’s disease is suboptimal and complicated by shared genetic risk factors and frequent co-pathology.
Barbara E. Spencer, Robin G. Jennings, Chun C. Fan, James B. Brewer   +3 more
doaj   +1 more source

Investigating the interaction between neuropsychiatry features and daily activities on social function in patients with Parkinson's disease with mild cognitive impairment

BJPsych Open, 2022
Background Social functioning is crucial for daily living and is an essential indicator of dementia in patients with Parkinson's disease. The pattern of social functioning in patients with Parkinson's disease without dementia (i.e.
Yi-Ru Chen, Chun-Hsiang Tan, Hui-Chen Su, Chung-Yao Chien, Pi-Shan Sung, Tien-Yu Lin, Tsung-Lin Lee, Rwei-Ling Yu   +7 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source