Results 81 to 90 of about 496,828 (359)

GRID SEARCH AND RANDOM SEARCH HYPERPARAMETER TUNING OPTIMIZATION IN XGBOOST ALGORITHM FOR PARKINSON’S DISEASE CLASSIFICATION

Barekeng
Parkinson's disease is a neurodegenerative disorder affecting motor abilities, with a prevalence of 329 cases per 100,000 individuals. Early diagnosis is crucial to prevent complications.
Shafa Fitria Aqilah Khansa, Nurissaidah Ulinnuha, Wika Dianita Utami   +2 more
doaj   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

CAPACIDADE FUNCIONAL EM IDOSOS COM DOENÇA DE ALZHEIMER E DOENÇA DE PARKINSON: REVISÃO BIBLIOGRÁFICA

Revista Pesquisa em Fisioterapia, 2014
Introdução: O processo de envelhecimento é considerado um fenômeno biológico, psicológico e social, podendo ser acompanhado por diversas alterações progressivas.
Itamara Prado Souza, Lidiane Meneses dos Santos, Viviane Santos Santana, Alexandre Gomes Feitosa   +3 more
doaj   +1 more source

Exact Results of Dimerization Order Parameter in $SU(n)$ Antiferromagnetic Chains

, 1993
After a proper definition of the dimerization order parameter for a spin-$S$ system, I show that this order parameter in the $SU(n)$ ($n=2S+1$) antiferromagnetic chains (or equivalently the $SU(2)$ spin-$S$ chains with Hamiltonians which project out ...
Affleck, Babujian, Barber, Baxter, Baxter, Chubukov, Haldane, Klümper, Parkinson, Parkinson, Temperley, Xian, Y. Xian   +12 more
core   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies

Beilstein Journal of Organic Chemistry
The ongoing quest to discover effective treatments for diseases remains a significant challenge for the scientific community. Multicomponent reactions (MCRs) have emerged as powerful tools in accelerating drug discovery, enabling the rapid generation of ...
Lucía Campos-Prieto, Aitor García-Rey, Eddy Sotelo, Ana Mallo-Abreu   +3 more
doaj   +1 more source

Toward understanding ambulatory activity decline in Parkinson disease [PDF]

, 2015
BACKGROUND: Declining ambulatory activity represents an important facet of disablement in Parkinson disease (PD). OBJECTIVE: The primary study aim was to compare the 2-year trajectory of ambulatory activity decline with concurrently evolving facets of ...
Cavanaugh, James T., Dibble, Leland E., Earhart, Gammon M., Ellis, Terry D., Ford, Matthew P., Foreman, K. Bo   +5 more
core   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Comments on Unified dark energy and dark matter from a scalar field different from quintessence [PDF]

, 2010
In a recent paper by C. Gao, M. Kunz, A. Liddle and D. Parkinson [arXiv:0912.0949], the unification of dark matter and dark energy was explored within a theory containing a scalar field of non-Lagrangian type.
Chimento, Luis P., Forte, Mónica
core   +2 more sources

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source