Results 141 to 150 of about 693,546 (355)

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K. [PDF]

, 2013
PMCID: PMC3591419This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
A Loquet, BI Giasson, BM Fung, C Wasmer, Chad M. Rienstra, CP Jaroniec, CR Bodner, CR Morcombe, D Eliezer, DS Wishart, DS Wishart, DS Wishart, E Oldfield, EA Greenbaum, Elisa Greggio, F Delaglio, G Comellas, G Comellas, G Comellas, G Cornilescu, Gemma Comellas, H Heise, H Heise, H van Melckebeke, J Li, JJ Zarranz, Julia M. George, K Iwata, K Takegoshi, KA Conway, KD Kloepper, L Narhi, Lars K. Rikardsen, LC Serpell, LR Lemkau, Luisel R. Lemkau, M Baldus, ME van Raaij, MG Spillantini, MH Polymeropoulos, MS Celej, N Ferguson, R Bussell, R Kruger, RA Fredenburg, S Hediger, Shin W. Lee, W Choi, Wendy S. Woods, WG Hoyer, Y Shen   +50 more
core   +3 more sources

Relationship between high dietary fat intake and Parkinson’s disease risk: a meta-analysis

Neural Regeneration Research, 2019
Objective: To assess whether dietary fat intake influences Parkinson’s disease risk. Data Sources: We systematically surveyed the Embase and PubMed databases, reviewing manuscripts published prior to October 2018.
Yan Qu, Xi Chen, Man-Man Xu, Qiang Sun
doaj   +1 more source

Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Advanced Science, EarlyView.
α‐synuclein aggregation in artificial cerebrospinal fluid (aCSF) leads to a distinct conformation with an electron density pocket motif found in aggregates from PD and MSA patients. Such fibrils has low stability outside the reaction conditions, hinting about the influence of cerebrospinal fluid components not only on the formation, but also on the ...
Rūta Sniečkutė, Darius Šulskis, Arūnė Jocytė, Urtė Venclovaitė, Rimgailė Tamulytė, Mantas Žiaunys, Vytautas Smirnovas, Andrius Sakalauskas   +7 more
wiley   +1 more source

SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway. [PDF]

, 2018
SIRT3 is a class III histone deacetylase that modulates energy metabolism, genomic stability and stress resistance. It has been implicated as a potential therapeutic target in a variety of neurodegenerative diseases, including Parkinson's disease (PD ...
Deng, Yong-Ning, Li, Yan-Bo, Liu, Jie, Qu, Qiu-Min, Su, Hua, Zhang, Jing-Yi, Zhang, Meng   +6 more
core   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb [PDF]

, 2017
Background Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs.
Caretta, Antonio, Mucignat, Carla
core   +2 more sources

A randomized controlled trial of quetiapine for psychosis in Parkinson’s disease

Neuropsychiatric Disease and Treatment, 2009
Paul Shotbolt1, Michael Samuel2,3, Chris Fox3,4, Anthony S David11Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King’s College, London, UK; 2Department of Neurology, King’s College hospital, London, UK; 3East Kent ...
Paul Shotbolt, Michael Samuel, Chris Fox, Anthony S David   +3 more
doaj  

Laterality Influences Brain Atrophy in Parkinson's Disease - a Voxel-based Morphometry Study

Frontiers in Neurology, 2016
Background: Several neuroimaging studies revealed widespread neurodegeneration in Parkinson's disease but only few considered the asymmetrical clinical presentation.
Maria Cristina Arci Santos, Lidiane Soares Campos, Rachel Paes Guimarães, Camila Callegari Piccinin, Paula Azevedo, Luiza Gonzaga Piovesana, Brunno Machado De Campos, Augusto Celso Scarparo Amato Filho, Fernando Cendes, Anelyssa D'Abreu   +9 more
doaj   +1 more source

Randomized trial of care management to improve Parkinson disease care quality

Neurology, 2019
Objective To test effects on care quality of Chronic Care Model-based Parkinson disease (PD) management. Methods This 2-group stratified randomized trial involved 328 veterans with PD in southwestern United States.
Karen I. Connor, E. Cheng, Frances Barry, H. Siebens, Martin L Lee, D. Ganz, B. Mittman, M. Connor, Lisa K. Edwards, M. McGowan, B. Vickrey   +10 more
semanticscholar   +1 more source