Results 191 to 200 of about 40,297 (296)

A Prediction Model for One‐Year Disability Risk Among Community‐Dwelling Older Adults in China: Integrating Physical, Metabolic, and Psychosocial Factors

Health Care Science, EarlyView.
Based on a prospective cohort of 1003 older adults, we developed and validated a practical disability prediction model integrating physical, metabolic, and psychosocial factors (AUC = 0.716), presented via a user‐friendly nomogram for community use. ABSTRACT Background Disability in older adults, characterized by progressive limitations in performing ...
Yanjun Ma, Chaofan Geng, Zhibin Wang, Yiwei Zhao, Lixin Ma, Pengpeng Ye, Leilei Duan, Guoping Peng, Yi Tang   +8 more
wiley   +1 more source

Longitudinal Swallowing and Salivary Changes With CLR 131 and Re‐Irradiation in Recurrent Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Patients with recurrent head and neck cancer (HNC) often present with severe, persistent dysphagia and xerostomia following prior chemoradiation. Although swallowing impairments and salivary dysfunction have been reported in this population, prior longitudinal studies have not examined changes in salivary composition or how these ...
Jenni Wu, Sara Gustafson, Meredith Hyun, Roxana Alexandridis, Mark Nicosia, Timothy McCulloch, Justine Bruce, Randall Kimple, Nicole Rogus‐Pulia   +8 more
wiley   +1 more source

Drivers of Rising Prevalence in Major Motor Neurodegenerative Diseases: Temporal Trends in Sweden and France (2003-2022). [PDF]

Neurology
Guinebretiere O, Yang F, Wei D, Calonge Q, Hu Y, Wirdefeldt K, Ingre C, Piehl F, Modig K, Ye W, Del Mar Amador M, Durrleman S, Bruneteau G, Louapre C, Corvol JC, Fang F, Nedelec T.   +16 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Promoting employment in young-onset Parkinson's disease: a staged intervention approach

This study investigated the employment experience of younger people with Parkinson’s Disease (PD). The aims of this study were formulated from reflections on clinical practice and observation of the often detrimental impact caused by relinquishing ...
Birleson, Angela
core  

Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial.

JAMA Neurol
Pahwa R, Moro E, Espay AJ, Evans A, Saint-Hilaire M, Torres-Russotto D, Sanchez R, Leoni M, Duvvuri S, Combs C, Chang I, Tringali S, Boiser J, Zadikoff C, Antonini A.   +14 more
europepmc   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Exposure to Air Pollutants and Lewy Body and Parkinson Disease-Related Dementias.

JAMA Netw Open
Davydow DS, Pontone GM, Okun MS, Armstrong MJ, Böttger TW, Geels C, Frohn LM, Brandt J, Dreier JW, Christensen J, Pedersen CB, Horsdal HT.   +11 more
europepmc   +1 more source

Cueing-assisted gamified augmented-reality home rehabilitation for gait and balance in people with Parkinson disease: feasibility and effectiveness in the clinical pathway. [PDF]

Phys Ther
Hoogendoorn EM, Geerse DJ, van Dam AT, van Hall SJ, van Doorn PF, Hardeman LES, Hoozemans MJM, Stins JF, Roerdink M.   +8 more
europepmc   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source