Results 81 to 90 of about 40,297 (296)

Deep Brain Stimulation of the Subthalamic Nucleus in Patients with Parkinson Disease with Prior Pallidotomy or Thalamotomy

Brain Sciences, 2018
Objective. To evaluate the efficacy of deep brain stimulation of the subthalamic nucleus (STN DBS) in patients with Parkinson disease (PD) who previously underwent lesioning of the basal ganglia. Material and methods.
Elena A. Khabarova, Natalia P. Denisova, Aleksandr B. Dmitriev, Konstantin V. Slavin, Leo Verhagen Metman   +4 more
doaj   +1 more source

Design of the WHIP-PD study: a phase II, twelve-month, dual-site, randomized controlled trial evaluating the effects of a cognitive-behavioral approach for promoting enhanced walking activity using mobile health technology in people with Parkinson-disease

BMC Neurology, 2020
Background Parkinson disease (PD) is a debilitating and chronic neurodegenerative disease resulting in ambulation difficulties. Natural walking activity often declines early in disease progression despite the relative stability of motor impairments.
Kerri S. Rawson, James T. Cavanaugh, Cristina Colon-Semenza, Tami DeAngelis, Ryan P. Duncan, Daniel Fulford, Michael P. LaValley, Pietro Mazzoni, Timothy Nordahl, Lisa M. Quintiliani, Marie Saint-Hilaire, Cathi A. Thomas, Gammon M. Earhart, Terry D. Ellis   +13 more
doaj   +1 more source

Effect of type of secondary task on cued gait on people with idiopathic Parkinson′s disease

Journal of Neurosciences in Rural Practice, 2014
ABSTRACT Introduction: The purpose of this study was to find out the effect of the secondary cognitive and motor task on cued gait in people with Idiopathic Parkinson′s disease (PD). Design and Setting: A repeated measure same subject design carried out at All India Institute of Medical Sciences, Neurology Department, New Delhi. Materials and
Chawla, Harsha, Walia, Shefali, Behari, Madhuri, Noohu, Majumi M.   +3 more
openaire   +2 more sources

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Parkinson's disease secondary to COVID-19: a systematic review

, 2022
Objetivo: O presente trabalho teve como objetivo realizar uma revisão sistemática a respeito da Doença de Parkinson e sua relação com a COVID-19. Métodos: Utilizamos e adaptamos os critérios presentes no PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) e objetivou a identificação de publicações revisadas por pares ...
Hamoy, Moises, Braga, Gabriel Hans Reis, Chaves, Jones Vinicius Santana, Maia, Ana Carolina Serrão, Cabral, Diego Arthur Castro, Campos, Fernanda Myllena Sousa, Medeiros, João Paulo do Vale, Cabral, Leonardo Giovanni Castro, Oliveira, Bruno Patricio dos Santos, Braga, Joyce Pantoja, de Mello, Vanessa Jóia, Paschoal, Eric Homero Albuquerque   +11 more
openaire   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Using a smartphone-based self-management platform to support medication adherence and clinical consultation in Parkinson\u27s disease [PDF]

, 2017
The progressive nature of Parkinson\u27s disease, its complex treatment regimens and the high rates of comorbid conditions make self-management and treatment adherence a challenge.
Stott RW, Chaudhuri KR, James B, Wang D, Teo J, Van Der Eijk M, Wang E, Steiger M, Williams A, Lakshminarayana R, Hellman B, Galtrey C, Rochester L, Burn D, Stamford J, Bloem BR, Pal S, Guzman NV, Barker RA   +18 more
core  

Treatment of Parkinson Disease, Time and Dosage

, 2011
Current available treatment for Parkinson disease has many drawbacks: single action on the nigrostriatal pathway, no halt of disease progression, pulsatile dopaminergic stimulation, complex treatment regimens, and motor complications.
Arbelo González, José Matías, Ángel Sesar, Javier López del Val, Del Val, Javier López, José Matías Arbelo, Sesar, Ángel   +5 more
core   +1 more source

Sequestration of Inflammation in Parkinson’s Disease via Stem Cell Therapy

, 2022
Parkinson’s disease is the second most common neurodegenerative disease. Insidious and progressive, this disorder is secondary to the gradual loss of dopaminergic signaling and worsening neuroinflammation, affecting patients’ motor ...
Borlongan, Cesario V, Monsour, Molly, Alayli, Adam, Borlongan, Cesario V., Gordon, Jonah, Hassan Choudhary, Cesario V. Borlongan, Molly Monsour, Gavin Lockard, Adam Alayli, Jonah Gordon, Lockard, Gavin, Choudhary, Hassan   +12 more
core   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source