Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain. [PDF]
, 2009 Alpha-synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is ...
Bernard, David J +10 more
core +2 more sources
Mitochondrial signaling on innate immunity activation in Parkinson disease
, 2022 João D. Magalhães, Sandra M. Cardoso
openalex +1 more source
A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study
Advanced Biology, EarlyView.Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers +10 more
wiley +1 more source
Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury
Advanced Functional Materials, EarlyView.After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen +9 more
wiley +1 more source
Glucocerebrosidase and its relevance to Parkinson disease [PDF]
, 2019 Jenny Do +3 more
openalex +1 more source
Biosupercapacitors for Human‐Powered Electronics
Advanced Functional Materials, EarlyView.Biosupercapacitors are emerging as biocompatible and integrative energy systems for next‐generation bioelectronics, offering rapid charge–discharge performance and mechanical adaptability. This review systematically categorizes their applications from external to organ‐level systems and highlights their multifunctional roles in sensing, actuation, and ...
Suhyeon Kim +7 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Buckling‐resistant and trace‐stacked (BRATS) intracortical microelectrode arrays (MEAs) eliminate the need for insertion aid and complex surgical setup, resulting in minimal inflammatory tissue response, compared to conventional flexible MEAs inserted with aid. Trace stacking effectively doubled the channel count without increasing the MEA shank width,
May Yoon Pwint, Delin Shi, X. Tracy Cui
wiley +1 more source
Pesticide exposure and the development of Parkinson disease: a systematic review of Brazilian studies [PDF]
Cadernos de Saúde Pública: Parkinson disease is the second most prevalent neurodegenerative disease globally. Parkinson disease etiology is not fully understood, it is believed to be a multifactorial disease. Pesticide exposure is highlighted among the factors.
Jean Rodrigo Santos +4 more
doaj +1 more source
PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease [PDF]
, 2015 Gary W. Beecham +31 more
openalex +1 more source
Frequency of Parkinson disease following COVID-19 infection: A two-year retrospective cohort study [PDF]
, 2023 Alexander Wang +2 more
openalex +1 more source