Results 261 to 270 of about 271,759 (355)

Expression Patterns of Retinoblastoma Protein in Parkinson Disease

, 2003
Kelly L. Jordan‐Sciutto, Robert E. Dorsey, Elisabeth Mole Chalovich, Robert Hammond, Cristian L. Achim   +4 more
openalex   +1 more source

Dual Hydrophilic‐Hydrophobic Core Architecture in Soy Glycinin Amyloid Fibrils Revealed by Cryo‐EM

Advanced Science, EarlyView.
While high‐resolution structures of animal and microbial amyloids are extensively characterized, the structural principles underlying plant‐derived amyloids remain largely unexplored. The study addresses this fundamental gap in knowledge by determining the first near‐atomic‐resolution cryo‐EM structures of amyloid fibrils derived from soy glycinin ...
Saiya Li, Shuangjian Li, Yijia Cheng, Yapeng Fang, Qin Cao, Yiping Cao   +5 more
wiley   +1 more source

Atypical Psychosis in Parkinson Disease: A Retrospective Study on 24-Hour Continuous Subcutaneous Infusion of Foslevodopa/Foscarbidopa. [PDF]

Neurol Clin Pract
Ge L, Kimura Y, Kakuda K, Ogawa K, Kajiyama Y, Asai K, Taniguchi S, Beck G, Nishio Y, Kim JH, Ikenaka K, Mochizuki H.   +11 more
europepmc   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Data-Driven Subtypes of Parkinson Disease Based on Dopamine Responsiveness. [PDF]

CNS Neurosci Ther
Wang JY, Zeng GL, Tang RT, Luo HT, Song YL, Zhou YY, Huang JF, Zhu SG, Zhang DL, Liu DN, Liu RP, Huang SS, Yuan CX, Zhu JH, Zhang X.   +14 more
europepmc   +1 more source

Computational Fluid Dynamic Model Prediction of Enhanced Glymphatic Clearance in Response to Focused Ultrasound‐Mediated Blood‐Brain Barrier Opening

Advanced Science, EarlyView.
Focused ultrasound‐mediated blood‐brain barrier opening (FUS BBBO) for enhanced drug delivery also augments glymphatic clearance. A computational model of an arteriole‐venule pair in the brain offers insight into the underlying biotransport mechanisms responsible for this mass clearance effect.
Ryan A. Gladwell, Delaney G. Fisher, Joshua D. Wythe, Christopher B. Highley, John R. Lukens, Richard J. Price   +5 more
wiley   +1 more source

Use of safinamide for treatment of Parkinson disease: real-world data from Spain. [PDF]

Drugs Context
Morales Casado MI, López Ariztegui N.
europepmc   +1 more source

Spatially Resolved Mapping of Voltage‐Gated Proton Channel Activity Reveals Delayed Proton Transport in Local Microenvironments

Advanced Science, EarlyView.
A revolutionary imaging platform integrating quantitative single‐molecule photobleaching with ratiometric fluorescence probes enables high‐throughput (≈2300 individually resolvable channels) mapping of individual proton channels in a large field (≈3000 µm2), overcoming the spatial and temporal limitations of conventional electrophysiology.
Jiahua Zhuang, Yang Xu, Yuxian Lu, Shiyang Lyu, Jie Tan, Jiandong Feng   +5 more
wiley   +1 more source