Results 261 to 270 of about 274,716 (345)

Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex

Advanced Science, EarlyView.
The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Evelyne Doudnikoff, Thierry Leste‐Lasserre, Thierry Amédée, Laurent Cognet, Laurent Groc, Urs Valentin Nägerl, Erwan Bezard   +11 more
wiley   +1 more source

Five-Year Outcomes from Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson Disease.

JAMA Neurol
Starr PA, Shivacharan RS, Goldberg E, Tröster AI, House PA, Giroux ML, Hebb AO, Whiting DM, Leichliter TA, Ostrem JL, Metman LV, Sani S, Karl JA, Siddiqui MS, Tatter SB, Haq IU, Machado AG, Gostkowski M, Tagliati M, Mamelak AN, Okun MS, Foote KD, Moguel-Cobos G, Ponce FA, Pahwa R, Lyons K, Buetefisch CM, Gross RE, Luca CC, Jagid JR, Revuelta GJ, Takacs I, Pourfar MH, Mogilner AY, Duker AP, Mandybur GT, Rosenow JM, Zadikoff C, Khandhar SM, Sedrak M, Phibbs FT, Neimat J, Durphy J, Ramirez-Zamora A, Pilitsis JG, Uitti RJ, Wharen R, Park MC, Vitek JL, INTREPID Study Group.   +49 more
europepmc   +1 more source

High‐Resolution Multiplexed Sequencing of Single‐Cell Full‐length Transcriptome Via Combinational Barcoded Tn5 Transposon Insertion

Advanced Science, EarlyView.
CBTi‐seq is reported, leveraging Tn5 transposase‐mediated molecular assembly of combinatorial barcodes and UMIs for high‐resolution multiplexed sequencing of the full‐length transcriptome in single cells. This approach achieves molecular resolution by end‐to‐end sequencing, enabling reconstruction of splice variants and accurate quantification of ...
Liyong He, Kaitong Dang, Qian Sun, Wenjia Wang, Wenbo Li, Wenyi Zhang, Kaiqiang Ye, Handong Wang, Zhengyue Li, Yan Guo, Zheng Li, Chencheng Yao, Peng Li, Yan Huang, Xiangwei Zhao   +14 more
wiley   +1 more source

Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases

, 2016
Mathieu Bourdenx, Jonathan Daniel, Emilie Génin, Federico N. Soria, Mireille Blanchard‐Desce, Erwan Bézard, Benjamin Dehay   +6 more
openalex   +2 more sources

HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis

Advanced Science, EarlyView.
This study investigates the impact of iron homeostasis on exercise. Loss of the HECT domain‐containing ubiquitin ligase E3 (HUWE1) in skeletal muscle restrains the exercise performance in mice with downregulated ferroportin expression leading to iron overload, which is ameliorated by dietary iron restriction.
Huike Jiao, Yuting Du, Danxia Zhou, Meng Bai, Xu Gao, Zhenyue Hao, Nan‐Jie Xu, Jiaqiang Liu, Ying Huang, Zhenji Gan, Jing Zhang   +10 more
wiley   +1 more source

Deep-Brain Stimulation and Intensive Rehabilitation in a Patient with Parkinson Disease: A Case Report. [PDF]

Am J Case Rep
Ferriero G, Magro VM, Ferrara PE, Ariani M, Coraci D, Codazza S, Maggi L, Ronconi G.   +7 more
europepmc   +1 more source

Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease

Advanced Science, EarlyView.
Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley   +1 more source

User Experiences of Limb-Worn Wearable Devices for Monitoring Parkinson Disease Motor Function and Blood Pressure: Usability Study. [PDF]

JMIR Form Res
Kenny L, Sica M, Crowe C, O'Mahony L, O'Flynn B, Mueller DS, Tedesco S, Barton J, Timmons S.   +8 more
europepmc   +1 more source

From central to peripheral: A new perspective on bladder dysfunction in Parkinson disease

Jackson A. Stachelek, Bernadette Zwaans, Yao‐Chi Chuang, Naoki Yoshimura, Michael B. Chancellor   +4 more
openalex   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source