Results 251 to 260 of about 63,333 (299)

Differential impact of manganese on glutamate clearance, electroencephalography, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Underlying glutamate dysregulation in Alzheimer's disease can be worsened by environmental factors like manganese (Mn) exposure. This study examined how excess Mn affects glutamatergic signaling and neurotransmission in a beta‐amyloid mouse model. METHODS APP/PSEN1 and control mice were exposed to systemic Mn subcutaneously.
Rebecca A. Buchanan, Alec T. Kramer, Erin S. Calipari, Aaron B. Bowman, William P. Nobis, Fiona E. Harrison   +5 more
wiley   +1 more source

The Relationship between Rest Tremor and Underlying Lewy Pathology in Essential Tremor: A Clinical‐Pathological Study of 201 Cases

Annals of Neurology, Volume 98, Issue 4, Page 741-749, October 2025.
Objectives Prospective studies demonstrated that essential tremor is a risk factor for Parkinson's disease. Identifying clinical markers for conversion from essential tremor to essential tremor‐Parkinson's disease would be of considerable value. Rest tremor can be present in advanced essential tremor and may be a harbinger of conversion. We examined (1)
Elan D. Louis, Nora C. Hernandez, Tomer Guy, Phyllis L. Faust   +3 more
wiley   +1 more source

Thalamic cholinergic innervation is spared in Alzheimer disease compared to parkinsonian disorders

, 2012
Vikas Kotagal, Martijn L.T.M. Müller, Daniel Kaufer, Robert A. Koeppe, Nicolaas I. Bohnen   +4 more
openalex   +2 more sources

The Impact of Bulbar and Upper Motor Neuron Involvement on Oculomotor Movement in Amyotrophic Lateral Sclerosis

Brain and Behavior, Volume 15, Issue 10, October 2025.
Oculomotor assessment revealed that ALS patients, especially those with bulbar or upper motor neuron (UMN) involvement, showed slower anti‐saccade reaction times and lower predictive saccade accuracy than healthy controls. These findings suggest distinct patterns of oculomotor dysfunction among ALS subgroups, highlighting the value of these metrics for
Dongchao Shen, Anfeng Liu, Xunzhe Yang, Qing Liu, Mingsheng Liu, Liying Cui   +5 more
wiley   +1 more source

Cortical Intra‐Layer Hypersynchronization in Levodopa‐Induced Dyskinesia Mouse Model

Brain and Behavior, Volume 15, Issue 10, October 2025.
Using Neuropixels technology, we obtained single‐cell data from thousands of neurons in the motor cortex and striatum of mice at different stages: WT, parkinsonian, and dyskinetic (LID). We found that LID is associated with intra‐layer hypersynchronization within the motor cortex, which may be an intrinsic network feature within the cortico–BG loop ...
Mohamed Khateb, Fadi Aeed, Shay Achvat, Shaked Ron, Yitzhak Schiller   +4 more
wiley   +1 more source

Orexin Deficiency in Narcolepsy: Molecular Mechanisms, Clinical Phenotypes, and Emerging Therapeutic Frontiers

Brain and Behavior, Volume 15, Issue 10, October 2025.
Orexin deficiency drives narcolepsy Type 1, leading to excessive daytime sleepiness, cataplexy, and REM intrusions. This review highlights recent advances (2023–2025) in molecular mechanisms, diagnostics, and emerging orexin‐targeted therapies with the potential for disease modification.
Rameesha Rauf, Salwa Asif, Abdallah AlSaafeen, Kaviprada Geathaa Dhantapaani, Maryam Muhammad Nadeem, Zohra Kamran Rao, Aliya Shaju Shahul Hameed, Karthik Chintharala, Muhammad Faheem Anwar, Asad Ali Ahmed Cheema   +9 more
wiley   +1 more source

Neuroleptic Malignant Syndrome: A Case Report of the Oldest Man in Literature

Clinical Case Reports, Volume 13, Issue 10, October 2025.
Radiographic findings in a 96 year old‐man with neuroleptic malignant syndrome highlights the importance of early recognition and attention to systemic complications. ABSTRACT A diagnosis of neuroleptic malignant syndrome (NMS) was made in a 96‐year‐old man, representing the oldest documented case in the existing medical literature.
Forouzan Elyasi, Mohsen Aarabi, Majidreza Adelani, Arghavan Fariborzifar, Marzieh Azizi   +4 more
wiley   +1 more source

Comprehensive Segmentation of Deep Grey Nuclei From Structural MRI Data

Human Brain Mapping, Volume 46, Issue 14, 01 October 2025.
The proposed deep grey nuclei pipeline can either work on white‐matter‐nulled (WMn) MPRAGE or standard T1 data, which gets converted to WMn‐like contrast prior to segmentation, which uses a multi‐atlas framework. In addition to 12 thalamic nuclei, 8 other structures comprising the basal ganglia, red nucleus, claustrum, and amygdala are segmented ...
Manojkumar Saranathan, Giuseppina Cogliandro, Thomas Hicks, Dianne Patterson, Behroze Vachha, Asma Hader, Mohammed Salman Shazeeb, Alberto Cacciola   +7 more
wiley   +1 more source

Investigating Dopamine Replacement–Associated Fluctuations in Cognition and Mood in Cognitively Unimpaired Parkinson's Disease

Movement Disorders Clinical Practice, Volume 12, Issue 10, Page 1609-1614, October 2025.
Abstract Background Non‐motor fluctuations, characterized by variability in mood and cognition, are prevalent in advanced Parkinson's disease (PD), but less is known about these fluctuations in early PD. Objective The objective was to characterize fluctuations in cognition and mood in early PD without cognitive impairment.
Abhimanyu Mahajan, Christopher B. Morrow, Joseph Seemiller, Kelly A. Mills, Gregory M. Pontone   +4 more
wiley   +1 more source

Identifying Common Disease Trajectories of Progressive Supranuclear Palsy with Electronic Health Records

Movement Disorders Clinical Practice, Volume 12, Issue 10, Page 1528-1538, October 2025.
Abstract Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disorder characterized by parkinsonism and impairments in balance, language, and cognition. As an atypical parkinsonism, PSP progresses rapidly, lacks effective treatments, and poses significant caregiving burdens. While prior studies have identified risk factors, they
Mingzhou Fu, Sriram Sankararaman, Keith A Vossel, Timothy S. Chang   +3 more
wiley   +1 more source