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Pediatric parkinsonism: clinical review and a proposed clinical algorithm [PDF]
Frontiers in NeurologyPediatric parkinsonism (PP) is a rare but disabling movement disorder characterized by bradykinesia and rigidity, with tremor being less frequent. Additional features include gait disturbances and impaired postural reflexes.
Valentina Naranjo-Lobo +7 more
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Parkinsonism induced by carbon monoxide intoxication: A “hidden gem” in the neurological literature [PDF]
Journal of Parkinson’s DiseaseParkinsonism can be acquired by various toxic exposures, among them carbon monoxide. Since the publication of a 1972 report of Parkinsonism associated with repeated episodes of carbon monoxide exposure, the medical literature has recorded multiple cases.
Omer Abdullah, Peter A. LeWitt
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Loneliness predicts worse Parkinsonism: a longitudinal, community-based, clinical-pathological study [PDF]
npj Parkinson's DiseaseLoneliness is increasingly acknowledged as important in parkinsonism-related disorders. However, little is known about reciprocal longitudinal relationships between loneliness and parkinsonism. In this study, 3,099 community-based individuals (Mage=78.09,
David Andrés González +3 more
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Journal of Neuroinflammation, 2023 Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1.
Max Stevenson +7 more
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Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection
PLoS Neglected Tropical Diseases, 2022 Dengue virus (DENV) is a flavivirus that is a significant cause of human disease costing billions of dollars per year in medical and mosquito control costs. It is estimated that up to 20% of DENV infections affect the brain.
Hannah K. Hopkins +2 more
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Safety, target engagement, and biomarker effects of bosutinib in dementia with Lewy bodies
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Bosutinib, a dual Abelson/Src inhibitor, was investigated in individuals with dementia with Lewy bodies (DLB). Methods A single site, randomized, double‐blind, placebo‐controlled study of the effects of oral bosutinib, 100 mg once daily for ...
Fernando L. Pagan +8 more
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Progress on diagnosis and treatment of functional parkinsonism
Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 Functional parkinsonism (FP) is a disorder caused by psychological factors rather than neurodegeneration. Functional parkinsonism has a great influence on patients' quality of life and daily function. However, due to overlapping with some of the symptoms
HUANG Pei, WANG Gang
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Sleep Disorders in Early-Onset Parkinsonism: A Population-Based Study
Journal of Parkinson’s Disease, 2023 Background: Sleep disturbances are common in parkinsonian disorders; however, whether sleep disorders affect individuals with early-onset parkinsonism and whether they differ from individuals with typical-onset parkinsonism is unknown.
Stuart J. McCarter +7 more
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Early-Onset Parkinsonism and Early-Onset Parkinson’s Disease: A Population-Based Study (2010-2015)
Journal of Parkinson’s Disease, 2021 Background: Early-onset Parkinson’s disease (EOPD), occurring between ages 40 and 55, carries social, societal, and personal consequences and may progress, with fewer comorbidities than typical, later-onset disease.
Emanuele Camerucci +9 more
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Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells
Disease Models & Mechanisms, 2016 X-linked dystonia-parkinsonism (XDP) is a hereditary neurodegenerative disorder involving a progressive loss of striatal medium spiny neurons. The mechanisms underlying neurodegeneration are not known, in part because there have been few cellular models ...
Naoto Ito +12 more
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