Results 21 to 30 of about 61,853 (265)
Neurobiology of Disease, 2020 Neuroinflammation plays a pathogenic role in neurodegenerative diseases and recent findings suggest that it may also be involved in X-linked Dystonia-Parkinsonism (XDP) pathogenesis.
Tiziana Petrozziello +16 more
doaj +1 more source
Incident mobility disability, parkinsonism, and mortality in community-dwelling older adults.
PLoS ONE, 2021 BackgroundMobility disability and parkinsonism are associated with decreased survival in older adults. This study examined the transition from no motor impairment to mobility disability and parkinsonism and their associations with death.Methods867 ...
Shahram Oveisgharan +3 more
doaj +1 more source
Modulation of Peripheral Mast Cell and Brain Microglia Axis via Kinase Inhibition
MetabolitesBackground/Objectives: Kinase inhibition is a hot therapeutic strategy for several human diseases, including neurodegeneration. Tyrosine kinase c-KIT activates peripheral mast cells, while other kinases including Abelson (c-Abl) promotes autophagy and ...
Xiaoguang Liu +6 more
doaj +1 more source
BiomedicinesIntroduction: Pathogenic mutations in leucine-rich repeat protein kinase-2 (LRRK2), particularly G2019S, constitute the most common cause of autosomal dominant PD.
Xiaoguang Liu +3 more
doaj +1 more source
Total daily physical activity, brain pathologies, and parkinsonism in older adults.
PLoS ONE, 2020 ObjectiveWe examined the association of physical activity, postmortem brain pathologies, and parkinsonism proximate to death in older adults.MethodsWe studied the brains of 447 older decedents participating in a clinical-autopsy cohort study. We deployed
Shahram Oveisgharan +6 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Case Report: Progressive Asymmetric Parkinsonism Secondary to CADASIL Without Dementia
Frontiers in Neurology, 2022 Parkinsonism is a rare phenotype of cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL), all of which involve cognitive decline. Normal cognition has not been reported in previous disease studies.
Weihang Guo +23 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Neuron-specific enolase in the blood serum as a diagnostic marker of Parkinsonism
Бюллетень сибирской медицины, 2005 In the article there were presented data about the received results of immune-enzyme analysis of neuron-specific enolase among patients with Parkinsonism (52) in comparison with control group of patients with discirculatory encephalopathy without ...
F. F. Gashilova, N. G. Zhukova
doaj +1 more source
Evaluation of Brain SPECT with 99mTc-TRODAT-1 in the Differential Diagnosis of Parkinsonism
Parkinson's Disease, 2022 Introduction. Brain SPECT with 99mTc-TRODAT-1 (SPECT-TRODAT) may be a useful tool in the differential diagnosis of Parkinsonism. Objective. To compare results of SPECT-TRODAT with clinical findings in patients with Parkinsonism. Methods. We evaluated 153
Giorgio Fabiani +4 more
doaj +1 more source