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Genetics of Progressive Supranuclear Palsy [PDF]

Journal of Movement Disorders, 2015
Progressive supranuclear palsy (PSP) is a neurodegenerative syndrome that is clinically characterized by progressive postural instability, supranuclear gaze palsy, parkinsonism and cognitive decline.
Sun Young Im, Young Eun Kim, Yun Joong Kim   +2 more
doaj   +3 more sources

Clinical Features of Patients With Progressive Supranuclear Palsy in an US Insurance Claims Database

Frontiers in Neurology, 2021
Background: Progressive supranuclear palsy is a rare neurodegenerative movement disorder and little is known about its epidemiology.Objective: Estimate age-adjusted prevalence of progressive supranuclear palsy and describe antecedent diagnoses and ...
Emma Viscidi, Irene Litvan, Tien Dam, Maneesh Juneja, Li Li, Henry Krzywy, Susan Eaton, Susan Hall, Joseph Kupferman, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger   +11 more
doaj   +1 more source

Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report

Journal of Medical Case Reports, 2021
Background Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy.
Huiping Li, Fang Yuan, Yaming Du, Tao Pan, Wanxin Wen, Shaoxue Li, Lixin Wang, Aili Lu   +7 more
doaj   +1 more source

Neuroimaging correlates of gait abnormalities in progressive supranuclear palsy

NeuroImage: Clinical, 2021
Progressive supranuclear palsy is a neurodegenerative disorder characterized primarily by tau inclusions and neurodegeneration in the midbrain, basal ganglia, thalamus, premotor and frontal cortex.
Irene Sintini, Kenton Kaufman, Hugo Botha, Peter R. Martin, Stacy R. Loushin, Matthew L. Senjem, Robert I. Reid, Christopher G. Schwarz, Clifford R. Jack Jr, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell, Farwa Ali   +12 more
doaj   +1 more source

The Significance of Asymmetry in the Assessment of Brain Perfusion in Atypical Tauopathic Parkinsonian Syndromes

Diagnostics, 2022
Progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS) are clinical manifestations of tauopathic Parkinsonian syndromes. Due to their overlapping symptomatology, the differential diagnosis of these entities may be difficult when ...
Piotr Alster, Natalia Madetko, Bartosz Migda, Michał Nieciecki, Michał Kutyłowski, Leszek Królicki, Andrzej Friedman   +6 more
doaj   +1 more source

9.4 T MR microscopy of the substantia nigra with pathological validation in controls and disease

NeuroImage: Clinical, 2017
Background: The anatomy of the substantia nigra on conventional MRI is controversial. Even using histological techniques it is difficult to delineate with certainty from surrounding structures.
LA Massey, MA Miranda, O Al-Helli, HG Parkes, JS Thornton, P-W So, MJ White, L Mancini, C Strand, J Holton, AJ Lees, T Revesz, TA Yousry   +12 more
doaj   +1 more source

Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy.

PLoS ONE, 2019
Radiological biomarkers have been reported for multiple system atrophy and progressive supranuclear palsy, but serum/plasma biomarkers for each disorder have not been established.
Akio Mori, Kei-Ichi Ishikawa, Shinji Saiki, Taku Hatano, Yutaka Oji, Ayami Okuzumi, Motoki Fujimaki, Takahiro Koinuma, Shin-Ichi Ueno, Yoko Imamichi, Nobutaka Hattori   +10 more
doaj   +1 more source

A longitudinal study of motor, oculomotor and cognitive function in progressive supranuclear palsy.

PLoS ONE, 2013
ObjectiveWe studied the annual change in measures of motor, oculomotor and cognitive function in progressive supranuclear palsy. This had twin objectives, to assess the potential for clinical parameters to monitor disease progression in clinical trials ...
Boyd C P Ghosh, Roger H S Carpenter, James B Rowe   +2 more
doaj   +1 more source

Comparison of gait in progressive supranuclear palsy, Parkinson’s disease and healthy older adults

BMC Neurology, 2012
Background Progressive supranuclear palsy and Parkinson’s disease have characteristic clinical and neuropathologic profiles, but also share overlapping clinical features. This study aimed to analyze the gait of people with progressive supranuclear palsy (
Egerton Thorlene, Williams David R, Iansek Robert   +2 more
doaj   +1 more source

Clinical features of progressive supranuclear palsy

Frontiers in Aging Neuroscience, 2023
BackgroundProgressive supranuclear palsy (PSP) is a clinically heterogenous atypical parkinsonian syndrome. Therefore, early recognition and correct diagnosis of PSP is challenging but essential.
Yafei Wen, Qijie Yang, Bin Jiao, Bin Jiao, Bin Jiao, Bin Jiao, Bin Jiao, Weiwei Zhang, Jingyi Lin, Yuan Zhu, Qian Xu, Qian Xu, Hui Zhou, Ling Weng, Ling Weng, Xinxin Liao, Yafang Zhou, Junling Wang, Jifeng Guo, Jifeng Guo, Jifeng Guo, Jifeng Guo, Xinxiang Yan, Xinxiang Yan, Xinxiang Yan, Xinxiang Yan, Hong Jiang, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Lu Shen, Lu Shen, Lu Shen, Lu Shen, Lu Shen, Lu Shen   +36 more
doaj   +1 more source