Results 41 to 50 of about 30,866 (234)

Progressive supranuclear palsy

, 2019
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized pathologically by 4 repeat tau deposition in various cell types and anatomical regions. Richardson's syndrome (RS) is the initially described and one of the clinical phenotypes associated with PSP pathology, characterized by vertical supranuclear gaze paly in particular ...
Giagkou, N., Höglinger, G.U., Stamelou, M.   +2 more
openaire   +4 more sources

The midbrain to pons ratio: a simple and specific MRI sign of progressive supranuclear palsy. [PDF]

, 2013
MRI-based measurements used to diagnose progressive supranuclear palsy (PSP) typically lack pathologic verification and are not easy to use routinely.
Burn, DJ, Fox, NC, Holton, J, Jäger, HR, Kallis, C, Lees, AJ, Ling, H, Massey, LA, Micallef, C, O'Sullivan, SS, Paviour, DC, Revesz, T, Williams, DR, Yousry, T   +13 more
core   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

The Effectiveness of Exercise Programs on Balance, Functional Ability, Quality of Life, and Depression in Progressive Supranuclear Palsy: A Case Study

Applied Sciences
Progressive supranuclear palsy is a form of atypical Parkinsonism. People living with Progressive Supranuclear Palsy have various symptoms, such as movement and cognitive disorders, which mainly affect balance and functional ability with an increased ...
Panagiotis Papamichail, Michail Michalas, Dimitris Krokos, Maria Balamoutsou, Panagiota Karkoula, Epameinondas Lyros, Vasiliki Sakellari, Anna Christakou   +7 more
doaj   +1 more source

Corticobasal syndrome: neuroimaging and neurophysiological advances [PDF]

, 2019
Corticobasal degeneration (CBD) is a neurodegenerative condition characterized by 4R-tau protein deposition in several brain regions that clinically manifests itself as a heterogeneous atypical parkinsonism typically expressing in the adulthood.
Asci, Francesco, Berardelli, Alfredo, Bologna, Matteo, Colosimo, Carlo, Di Stasio, Flavio, Fabbrini, Giovanni, Marsili, Luca, Pantano, Patrizia, Suppa, Antonio, Upadhyay, Neeraj   +9 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Gene-Environment Interactions in Progressive Supranuclear Palsy

Frontiers in Neurology, 2021
Several genetic and environmental factors have been reported in progressive supranuclear palsy (PSP), although none were identified as a definitive cause. We aimed to explore potential gene-environment interactions in PSP.
Irene Litvan, James A. Proudfoot, Eden R. Martin, David Standaert, David Riley, Deborah Hall, Connie Marras, Ece Bayram, Richard M. Dubinsky, Yvette Bordelon, Stephen Reich, David Shprecher, David Shprecher, Benzi Kluger, Christopher Cunningham, Gerard D. Schellenberg, Joseph Jankovic   +16 more
doaj   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study

The Lancet: Digital Health, 2019
Summary: Background: Development of valid, non-invasive biomarkers for parkinsonian syndromes is crucially needed. We aimed to assess whether non-invasive diffusion-weighted MRI can distinguish between parkinsonian syndromes using an automated imaging ...
Derek B Archer, PhD, Justin T Bricker, MS, Winston T Chu, BS, Roxana G Burciu, PhD, Johanna L McCracken, BS, Song Lai, ProfPhD, Stephen A Coombes, PhD, Ruogu Fang, PhD, Angelos Barmpoutis, PhD, Daniel M Corcos, PhD, Ajay S Kurani, PhD, Trina Mitchell, MS, Mieniecia L Black, MPH, Ellen Herschel, BS, Tanya Simuni, ProfMD, Todd B Parrish, ProfPhD, Cynthia Comella, ProfMD, Tao Xie, MD, Klaus Seppi, ProfMD, Nicolaas I Bohnen, ProfMD, Martijn LTM Müller, PhD, Roger L Albin, ProfMD, Florian Krismer, MD, Guangwei Du, MD, Mechelle M Lewis, PhD, Xuemei Huang, ProfMD, Hong Li, PhD, Ofer Pasternak, PhD, Nikolaus R McFarland, MD, Michael S Okun, ProfMD, David E Vaillancourt, ProfPhD   +30 more
doaj   +1 more source

Understanding fatigue in progressive supranuclear palsy

Scientific Reports, 2021
Fatigue is a common and disabling non-motor symptom (NMS) of Parkinson’s disease (PD); however, it has been poorly understood in patients with progressive supranuclear palsy (PSP).
Jong Hyeon Ahn, Joomee Song, Dong Yeong Lee, Jinyoung Youn, Jin Whan Cho   +4 more
doaj   +1 more source