Results 31 to 40 of about 61,853 (265)

Drug-induced parkinsonism: what should a psychiatrist know?

Revista Mexicana de Neurociencia, 2021
Drug-induced parkinsonism is the main cause of secondary parkinsonism in the world. Antipsychotics, antidepressants, and mood stabilizers are the most common drugs implicated in the parkinsonism.
Santiago Vásquez-Builes, Catalina Salazar-Duque, María P. Tieck-Fernández, Isabel C. Rojas-Gallego, Gustavo A. Díaz-Silva   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

c-KIT inhibitors reduce pathology and improve behavior in the Tg(SwDI) model of Alzheimer’s disease

Life Science Alliance
Brain-penetrant c-KIT inhibitors, BK40143 and BK4019,7 regulate harmonious mechanisms via autophagy and regulation of mast-cell-microglial communication and improve cognition in Alzheimer’s models.
Max Stevenson, Michaeline L Hebron, Xiaoguang Liu, Kaluvu Balaraman, Christian Wolf, Charbel Moussa   +5 more
doaj   +1 more source

Transcranial Sonography in Parkinson’s Disease and Parkinsonism

Neurological Sciences and Neurophysiology, 2023
ABSTRACT Background: Transcranial sonography (TCS) is a noninvasive imaging method that practices ultrasound waves to examine the brain structure changes in many neurological pathologies, including Parkinson’s disease (PD) and parkinsonism.
Seyma Eroglu Durmaz, Oguzhan Kursun, Nese Oztekin, Yesim Sucullu Karadag   +3 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Tyrosine kinases: multifaceted receptors at the intersection of several neurodegenerative disease-associated processes

Frontiers in Dementia
Tyrosine kinases (TKs) are catalytic enzymes activated by auto-phosphorylation that function by phosphorylating tyrosine residues on downstream substrates.
Max Stevenson, Norah K. Algarzae, Charbel Moussa   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

[Parkinson's disease and parkinsonism].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2017
Abstract This chapter discusses the evidence-based pharmacological management of motor and non-motor (autonomic disease, dementia, psychosis, depression, and sleep disorder) Parkinson’s disease (PD) and Parkinson’s plus syndromes (progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and corticobasal degeneration (CBD ...
Kashif Waqar, Faiz, Lasse, Pihlstrøm
openaire   +3 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source