Results 31 to 40 of about 74,974 (313)

Parkinson's Disease and Parkinsonism: Neuropathology [PDF]

Cold Spring Harbor Perspectives in Medicine, 2012
Parkinsonism, the clinical term for a disorder with prominent bradykinesia and variable associated extrapyramidal signs and symptoms, is accompanied by degeneration of the nigrostriatal dopaminergic system, with neuronal loss and reactive gliosis in the substantia nigra found at autopsy.
openaire   +2 more sources

Neuron-specific enolase in the blood serum as a diagnostic marker of Parkinsonism

Бюллетень сибирской медицины, 2005
In the article there were presented data about the received results of immune-enzyme analysis of neuron-specific enolase among patients with Parkinsonism (52) in comparison with control group of patients with discirculatory encephalopathy without ...
F. F. Gashilova, N. G. Zhukova
doaj   +1 more source

Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations. [Elektronisk resurs]

, 2013
Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35) or recessive (parkin/PARK2, PINK1, DJ1/PARK7) Parkinson's disease (PD) or parkinsonism.
Lund University., Puschmann, Andreas,
core   +1 more source

Parkinson’s Disease and Parkinsonism

The Journal of Turkish Family Physician, 2022
Parkinson’s disease (PD), or paralysis agitans is a common neurodegenerative and heterogeneous disorder. Parkinson’s symptoms include bradykinesia, rigidity and tremor. PD is pathologically characterized by the loss of dopaminergic neurons of the substantia nigra. Treatment involves pharmacologic and nonpharmacologic approaches.
Tuba Erdoğan Soyukibar, Dilaver Kaya
openaire   +1 more source

Modulation of Peripheral Mast Cell and Brain Microglia Axis via Kinase Inhibition

Metabolites
Background/Objectives: Kinase inhibition is a hot therapeutic strategy for several human diseases, including neurodegeneration. Tyrosine kinase c-KIT activates peripheral mast cells, while other kinases including Abelson (c-Abl) promotes autophagy and ...
Xiaoguang Liu, Michaeline Hebron, Kaluvu Balaraman, Louis Ballard, Kimberly Liu, Max Stevenson, Charbel Moussa   +6 more
doaj   +1 more source

Total daily physical activity, brain pathologies, and parkinsonism in older adults.

PLoS ONE, 2020
ObjectiveWe examined the association of physical activity, postmortem brain pathologies, and parkinsonism proximate to death in older adults.MethodsWe studied the brains of 447 older decedents participating in a clinical-autopsy cohort study. We deployed
Shahram Oveisgharan, Robert J Dawe, Sue E Leurgans, Lei Yu, Julie A Schneider, David A Bennett, Aron S Buchman   +6 more
doaj   +1 more source

Incident mobility disability, parkinsonism, and mortality in community-dwelling older adults.

PLoS ONE, 2021
BackgroundMobility disability and parkinsonism are associated with decreased survival in older adults. This study examined the transition from no motor impairment to mobility disability and parkinsonism and their associations with death.Methods867 ...
Shahram Oveisgharan, Lei Yu, David A Bennett, Aron S Buchman   +3 more
doaj   +1 more source

Optimizing Treatment in Undertreated Late-Stage Parkinsonism : A Pragmatic Randomized Trial

, 2020
Background: Treatment of patients with late-stage parkinsonism is often sub-optimal. Objective: To test the effectiveness of recommendations by a movement disorder specialist with expertise in late-stage parkinsonism.
Meinders, Marjan J., Weerkamp, Nico J.,, Schmotz, Christian,, Meissner, Wassilios G., Schragand, Anette,, Weerkamp, Nico J., Bloem, Bas R.,, Lorenzl, Stefan,, Boraud, Thomas, Bloem, Bas R., Schragand, Anette, Rosqvist, Kristina, Meinders, Marjan J.,, Hommel, Adrianus L.A.J., Timpka, Jonathan,, Hommel, Adrianus L.A.J.,, Meissner, Wassilios G.,, Rosqvist, Kristina,, Boraud, Thomas,, Lorenzl, Stefan, Odin, Per, Care of Late Stage Parkinsonism (CLaSP) Consortium, Meinders, Marjan, Tison, Francois,, Wittenberg, Michael,, Ferreira, Joaquim, Timpka, Jonathan, Koopmans, Raymond, Tison, Francois, Ferreira, Joaquim J., Wittenberg, Michael, Richinger, Carmen,, Dodel, Richard,, Dodel, Richard, Koopmans, Raymond T.,, Odin, Per,, Bloem, Bas, Ferreira, Joaquim J.,, Coelho, Miguel, Koopmans, Raymond T., Weerkamp, Nico, Lund University., Meissner, Wassilios, Richinger, Carmen, Schmotz, Christian, Coelho, Miguel,   +45 more
core   +1 more source

Synergistic Effects of Multi-Kinase Inhibition on LRRK2-G2019S and Alpha-Synuclein Pathologies in Models of Parkinson’s Disease

Biomedicines
Introduction: Pathogenic mutations in leucine-rich repeat protein kinase-2 (LRRK2), particularly G2019S, constitute the most common cause of autosomal dominant PD.
Xiaoguang Liu, Sean Baxely, Michaeline L. Hebron, Charbel Moussa   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source