Results 31 to 40 of about 82,028 (307)

Parkinson's Disease and Parkinsonism: Neuropathology [PDF]

Cold Spring Harbor Perspectives in Medicine, 2012
Parkinsonism, the clinical term for a disorder with prominent bradykinesia and variable associated extrapyramidal signs and symptoms, is accompanied by degeneration of the nigrostriatal dopaminergic system, with neuronal loss and reactive gliosis in the substantia nigra found at autopsy.
openaire   +2 more sources

Study on drug-induced parkinsonism and its clinical patterns in Eastern Indian population

APIK Journal of Internal Medicine, 2023
Background: Drug-induced parkinsonism (DIP) is important as it is reversible if identified and treated early. We present herewith various clinical patterns and drugs commonly causing DIP.
Praveen Kumar Yadav
doaj   +1 more source

Parkinsonism caused by cavernoma located in basal ganglion

, 2005
Deep-seated cavernoma or cavernous angioma is a very rare clinical entity, as is basal ganglia cavernoma presenting with Parkinsonism. The authors demonstrate a 56-year-old man with a cavernoma located in basal ganglion, who subsequently developed ...
Alver, I, Tanriverdi, T, Ertan, S, Benbir, G, Uzan, M   +4 more
core   +1 more source

Pipeline to gene discovery - Analysing familial Parkinsonism in the Queensland Parkinson's Project [PDF]

, 2018
Introduction: Family based study designs provide an informative resource to identify disease-causing mutations. The Queensland Parkinson's Project (QPP) has been involved in numerous genetic screening studies; however, details of the families enrolled ...
Silburn, Peter, Ilaria Guella, Fowdar, Javed Y, Mellick, George, George D. Mellick, Farrer, Matthew J, Bentley, Steven R, Guella, Ilaria, Wood, Stephen A, Wood, Stephen, Matthew J. Farrer, Stephanie Bortnick, Javed Y. Fowdar, Peter A. Silburn, Silburn, Peter A, Mellick, George D, Bortnick, Stephanie, Fowdar, Javed, Farrer, Matthew, Stephen A. Wood, Bentley, Steven, Steven R. Bentley   +21 more
core   +1 more source

Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations. [Elektronisk resurs]

, 2013
Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35) or recessive (parkin/PARK2, PINK1, DJ1/PARK7) Parkinson's disease (PD) or parkinsonism.
Lund University., Puschmann, Andreas,
core   +1 more source

Modulation of Peripheral Mast Cell and Brain Microglia Axis via Kinase Inhibition

Metabolites
Background/Objectives: Kinase inhibition is a hot therapeutic strategy for several human diseases, including neurodegeneration. Tyrosine kinase c-KIT activates peripheral mast cells, while other kinases including Abelson (c-Abl) promotes autophagy and ...
Xiaoguang Liu, Michaeline Hebron, Kaluvu Balaraman, Louis Ballard, Kimberly Liu, Max Stevenson, Charbel Moussa   +6 more
doaj   +1 more source

Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex

Neurobiology of Disease, 2020
Neuroinflammation plays a pathogenic role in neurodegenerative diseases and recent findings suggest that it may also be involved in X-linked Dystonia-Parkinsonism (XDP) pathogenesis.
Tiziana Petrozziello, Alexandra N. Mills, Christine A. Vaine, Ellen B. Penney, Cara Fernandez-Cerado, Gierold Paul A. Legarda, M. Salvie Velasco-Andrada, Patrick J. Acuña, Mark A. Ang, Edwin L. Muñoz, Cid Czarina E. Diesta, Regina Macalintal-Canlas, Geraldine Acuña-Sunshine, Laurie J. Ozelius, Nutan Sharma, D. Cristopher Bragg, Ghazaleh Sadri-Vakili   +16 more
doaj   +1 more source

Incident mobility disability, parkinsonism, and mortality in community-dwelling older adults.

PLoS ONE, 2021
BackgroundMobility disability and parkinsonism are associated with decreased survival in older adults. This study examined the transition from no motor impairment to mobility disability and parkinsonism and their associations with death.Methods867 ...
Shahram Oveisgharan, Lei Yu, David A Bennett, Aron S Buchman   +3 more
doaj   +1 more source

Optimizing Treatment in Undertreated Late-Stage Parkinsonism : A Pragmatic Randomized Trial

, 2020
Background: Treatment of patients with late-stage parkinsonism is often sub-optimal. Objective: To test the effectiveness of recommendations by a movement disorder specialist with expertise in late-stage parkinsonism.
Meinders, Marjan J., Weerkamp, Nico J.,, Schmotz, Christian,, Meissner, Wassilios G., Schragand, Anette,, Weerkamp, Nico J., Bloem, Bas R.,, Lorenzl, Stefan,, Boraud, Thomas, Bloem, Bas R., Schragand, Anette, Rosqvist, Kristina, Meinders, Marjan J.,, Hommel, Adrianus L.A.J., Timpka, Jonathan,, Hommel, Adrianus L.A.J.,, Meissner, Wassilios G.,, Rosqvist, Kristina,, Boraud, Thomas,, Lorenzl, Stefan, Odin, Per, Care of Late Stage Parkinsonism (CLaSP) Consortium, Meinders, Marjan, Tison, Francois,, Wittenberg, Michael,, Ferreira, Joaquim, Timpka, Jonathan, Koopmans, Raymond, Tison, Francois, Ferreira, Joaquim J., Wittenberg, Michael, Richinger, Carmen,, Dodel, Richard,, Dodel, Richard, Koopmans, Raymond T.,, Odin, Per,, Bloem, Bas, Ferreira, Joaquim J.,, Coelho, Miguel, Koopmans, Raymond T., Weerkamp, Nico, Lund University., Meissner, Wassilios, Richinger, Carmen, Schmotz, Christian, Coelho, Miguel,   +45 more
core   +1 more source

Synergistic Effects of Multi-Kinase Inhibition on LRRK2-G2019S and Alpha-Synuclein Pathologies in Models of Parkinson’s Disease

Biomedicines
Introduction: Pathogenic mutations in leucine-rich repeat protein kinase-2 (LRRK2), particularly G2019S, constitute the most common cause of autosomal dominant PD.
Xiaoguang Liu, Sean Baxley, Michaeline L. Hebron, Charbel Moussa   +3 more
doaj   +1 more source