Results 51 to 60 of about 74,974 (313)
Transcranial Sonography in Parkinson’s Disease and Parkinsonism
Neurological Sciences and Neurophysiology, 2023 ABSTRACT Background: Transcranial sonography (TCS) is a noninvasive imaging method that practices ultrasound waves to examine the brain structure changes in many neurological pathologies, including Parkinson’s disease (PD) and parkinsonism.
Seyma Eroglu Durmaz +3 more
openaire +2 more sources
Frontiers in DementiaTyrosine kinases (TKs) are catalytic enzymes activated by auto-phosphorylation that function by phosphorylating tyrosine residues on downstream substrates.
Max Stevenson +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability
, 2013 Familial parkinson's disease is both clinically and genetically heterogeneous. By mapping the disease locus with a lod score of 5.13 to a < 3.5 Mbp region at 1p31.3 in a consanguineous family and subsequent exome sequencing analysis, we identified ...
Karasoy, Hatice +4 more
core +1 more source
[Parkinson's disease and parkinsonism].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2017 Abstract This chapter discusses the evidence-based pharmacological management of motor and non-motor (autonomic disease, dementia, psychosis, depression, and sleep disorder) Parkinson’s disease (PD) and Parkinson’s plus syndromes (progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and corticobasal degeneration (CBD ...
Kashif Waqar, Faiz, Lasse, Pihlstrøm
openaire +3 more sources
Postoperative and Postpartum Onset of Chronic Parkinsonism: Four Case Reports
International Journal of Medical Students, 2014 Background: Certain environmental exposures have been linked to the development of parkinsonism. We report four cases in which the onset of chronic parkinsonism occurred immediately or soon after surgery or childbirth.
Manish Ramani B. +2 more
doaj +3 more sources
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
SPG7 with parkinsonism responsive to levodopa and dopaminergic deficit
, 2018 We report a 55-year-old woman with a long history of a gait disturbance that was followed by dysarthria and urinary incontinence. She underwent brain MRI, SPECT with TRODAT imaging and whole-exome sequencing, revealing the diagnosis of SPG7.
Rocha Marussi, Victor Hugo +13 more
core +1 more source
Dysfunction of Protein Quality control in Parkinsonism-Dementia complex of Guam [PDF]
, 2018 Guam parkinsonism-dementia complex (G-PDC) is an enigmatic neurodegenerative disease that is endemic to the Pacific island of Guam. G-PDC patients are clinically characterized by progressive cognitive impairment and parkinsonism.
Verheijen, Bert M. +2 more
core +1 more source