Results 41 to 50 of about 74,974 (313)

Prevalence and functional impact of parkinsonian signs in older adults from the Good Aging in Skåne study [Elektronisk resurs] : Parkinsonian signs in older adults

, 2023
Introduction Mild parkinsonian signs (MPS) have been characterized by several definitions, using the motor part of the Unified Parkinson's Disease Rating Scale (UPDRS).
Elmståhl, Sölve,, Algotsson, Charlotte,, Lund University., Siennicki-Lantz, Arkadiusz,, Rosso, Aldana,   +4 more
core   +1 more source

Evaluation of Brain SPECT with 99mTc-TRODAT-1 in the Differential Diagnosis of Parkinsonism

Parkinson's Disease, 2022
Introduction. Brain SPECT with 99mTc-TRODAT-1 (SPECT-TRODAT) may be a useful tool in the differential diagnosis of Parkinsonism. Objective. To compare results of SPECT-TRODAT with clinical findings in patients with Parkinsonism. Methods. We evaluated 153
Giorgio Fabiani, Carlos Henrique Ferreira Camargo, Raul Martins Filho, Gabriel Sampaio Froehner, Hélio Afonso Ghizoni Teive   +4 more
doaj   +1 more source

Case Report: Progressive Asymmetric Parkinsonism Secondary to CADASIL Without Dementia

Frontiers in Neurology, 2022
Parkinsonism is a rare phenotype of cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL), all of which involve cognitive decline. Normal cognition has not been reported in previous disease studies.
Weihang Guo, Baolei Xu, Baolei Xu, Baolei Xu, Baolei Xu, Hong Sun, Hong Sun, Hong Sun, Hong Sun, Jinghong Ma, Jinghong Ma, Jinghong Ma, Jinghong Ma, ShanShan Mei, ShanShan Mei, ShanShan Mei, ShanShan Mei, Jingrong Zeng, Junyan Sun, Junyan Sun, Erhe Xu, Erhe Xu, Erhe Xu, Erhe Xu   +23 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Striatal neuroinflammation promotes parkinsonism in rats

, 2008
The specific role of neuroinflammation in the pathogenesis of Parkinson's disease remains to be fully elucidated. By infusing lipopolysaccharide (LPS) into the striatum, we investigated the effect of neuroinflammation on the dopamine nigrostriatal ...
Randy L Hunter, Wayne Cass, Patrick G Sullivan, Pandya, Jignesh D., Dong-Young Choi, Don Gash, Patrick Sullivan, Hyoung-Chun Kim, Cass, Wayne A., Jignesh D Pandya, Hunter, Randy L., Don M Gash, Bing, Guoying, Randy Hunter, Eun-Joo Shin, Jignesh Pandya, Wayne A Cass, Gash, Don M., Sullivan, Patrick G., Choi, Dong-Young, Shin, Eun-Joo, Liu, Mei, Kim, Hyoung-Chun, Mei Liu, Guoying Bing   +24 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

c-KIT inhibitors reduce pathology and improve behavior in the Tg(SwDI) model of Alzheimer’s disease

Life Science Alliance
Brain-penetrant c-KIT inhibitors, BK40143 and BK4019,7 regulate harmonious mechanisms via autophagy and regulation of mast-cell-microglial communication and improve cognition in Alzheimer’s models.
Max Stevenson, Michaeline L Hebron, Xiaoguang Liu, Kaluvu Balaraman, Christian Wolf, Charbel Moussa   +5 more
doaj   +1 more source

Drug-induced parkinsonism: what should a psychiatrist know?

Revista Mexicana de Neurociencia, 2021
Drug-induced parkinsonism is the main cause of secondary parkinsonism in the world. Antipsychotics, antidepressants, and mood stabilizers are the most common drugs implicated in the parkinsonism.
Santiago Vásquez-Builes, Catalina Salazar-Duque, María P. Tieck-Fernández, Isabel C. Rojas-Gallego, Gustavo A. Díaz-Silva   +4 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

A homozygous frameshift mutation of sepiapterin reductase gene causing parkinsonism with onset in childhood

, 2012
We report two siblings that presented hypotonia and very early-onset parkinsonism. Homozygosity mapping using SNP genome scan data identified a candidate locus that was 12.2 Mega base pairs.
Aslıhan Tolun, Hanagasi, Haşmet Ayhan, Çiğdem Köroğlu, Tasan, Ersan, Dursun, Burcu, Burcu Dursun, Erşan Taşan, Lohmann, Ebba, Ebba Lohmann, Hasmet A. Hanagasi, TOLUN, ASLIHAN, Koroglu, Cigdem   +11 more
core   +1 more source