Results 41 to 50 of about 61,853 (265)
Pediatric parkinsonism: clinical review and a proposed clinical algorithm
Frontiers in NeurologyPediatric parkinsonism (PP) is a rare but disabling movement disorder characterized by bradykinesia and rigidity, with tremor being less frequent. Additional features include gait disturbances and impaired postural reflexes.
Valentina Naranjo-Lobo +7 more
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Diagnostics and treatment of vascular parkinsonism [PDF]
Саратовский научно-медицинский журнал, 2010 The article presents clinical syndromic classification of parkinsonism in relation to etiological factors. It also studies epidemiologic and historical aspects of vascular parkinsonism.
V.V. Yudina +2 more
doaj
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Postoperative and Postpartum Onset of Chronic Parkinsonism: Four Case Reports
International Journal of Medical Students, 2014 Background: Certain environmental exposures have been linked to the development of parkinsonism. We report four cases in which the onset of chronic parkinsonism occurred immediately or soon after surgery or childbirth.
Manish Ramani B. +2 more
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Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Loneliness predicts worse Parkinsonism: a longitudinal, community-based, clinical-pathological study
npj Parkinson's DiseaseLoneliness is increasingly acknowledged as important in parkinsonism-related disorders. However, little is known about reciprocal longitudinal relationships between loneliness and parkinsonism. In this study, 3,099 community-based individuals (Mage=78.09,
David Andrés González +3 more
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Systematic Review of Parkinsonism in Cerebrotendinous Xanthomatosis
Neurology InternationalBackground: Cerebrotendinous Xanthomatosis (CTX) is a rare, inherited metabolic disease caused by pathogenic variants in CYP27A1. The clinical presentation of this progressive disease includes cognitive deficits, ataxia, peripheral neuropathy, and ...
Jennifer Hanson, Penelope E. Bonnen
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
BMC Neurology, 2019 Background Parkinsonism is a complex multifactorial neurodegenerative disorder, in which genetic and environmental risk factors may both play a role. Among environmental risk factors cocaine was earlier ambiguously linked to Parkinsonism.
Anett Illés +5 more
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