Results 11 to 20 of about 74,974 (313)

Early-Onset Parkinsonism and Early-Onset Parkinson’s Disease: A Population-Based Study (2010-2015)

Journal of Parkinson’s Disease, 2021
Background: Early-onset Parkinson’s disease (EOPD), occurring between ages 40 and 55, carries social, societal, and personal consequences and may progress, with fewer comorbidities than typical, later-onset disease.
Emanuele Camerucci, Cole D. Stang, Mania Hajeb, Pierpaolo Turcano, Aidan F. Mullan, Peter Martin, Owen A. Ross, James H. Bower, Michelle M. Mielke, Rodolfo Savica   +9 more
doaj   +1 more source

A novel homozygous DJ1 mutation causes parkinsonism and ALS in a Turkish family

, 2021
Objective: DJ1 mutations (PARK7) are among the monogenic causes of early-onset autosomal recessive parkinsonism. Here, we report clinical and genetic findings in a family with Turkish origin carrying a new DJ1 mutation and presenting with early-onset ...
Hanagasi, Haşmet Ayhan, Gasser, T., Heutink, Peter, Basak, Nazh, Lohmann, E., Kartal, Ece, Bilgic, B., Heutink, P., Simon-Sanchez, Javier, Guven, Gamze, Basak, N., Guven, G., Emre, Murat, Emre, M., Hauser, A. -K., Lohmann, Ebba, Bilgic, Basar, Hauser, Ann-Kathrin, Gasser, Thomas, Simon-Sanchez, J., Giri, A., Giri, Anamika   +21 more
core   +1 more source

Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells

Disease Models & Mechanisms, 2016
X-linked dystonia-parkinsonism (XDP) is a hereditary neurodegenerative disorder involving a progressive loss of striatal medium spiny neurons. The mechanisms underlying neurodegeneration are not known, in part because there have been few cellular models ...
Naoto Ito, William T. Hendriks, Jyotsna Dhakal, Christine A. Vaine, Christina Liu, David Shin, Kyle Shin, Noriko Wakabayashi-Ito, Marisela Dy, Trisha Multhaupt-Buell, Nutan Sharma, Xandra O. Breakefield, D. Cristopher Bragg   +12 more
doaj   +1 more source

Tumoral parkinsonism—Parkinsonism secondary to brain tumors, paraneoplastic syndromes, intracranial malformations, or oncological intervention, and the effect of dopaminergic treatment

Brain and Behavior, 2023
Introduction Secondary tumoral parkinsonism is a rare phenomenon that develops as a direct or indirect result of brain neoplasms or related conditions.
Gustav Cedergren Weber, Jonathan Timpka, Anna Rydelius, Johan Bengzon, Per Odin   +4 more
doaj   +1 more source

Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration

Drugs in R&D, 2019
Background and objectives Inhibition of Abelson (Abl) tyrosine kinase as a therapeutic target has been gaining attention in neurodegeneration. Post-mortem Alzheimer’s and Parkinson’s disease brains show that the levels of several other tyrosine kinases ...
Alan J. Fowler, Michaeline Hebron, Alexander A. Missner, Ruchong Wang, Xiaokong Gao, Bahjat T. Kurd-Misto, Xiaoguang Liu, Charbel E.-H. Moussa   +7 more
doaj   +1 more source

New Perspective on Parkinsonism in Frontotemporal Lobar Degeneration [PDF]

Journal of Movement Disorders, 2013
Frontotemporal dementia (FTD) is the second most common type of presenile dementia. Three clinical prototypes have been defined; behavioral variant FTD, semantic dementia, and progressive nonfluent aphasia.
Hee Kyung Park, Sun J. Chung
doaj   +1 more source

Tyrosine kinase inhibition increases functional parkin‐Beclin‐1 interaction and enhances amyloid clearance and cognitive performance

EMBO Molecular Medicine, 2013
Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β‐amyloid (plaques) and hyper‐phosphorylated Tau (tangles).
Irina Lonskaya, Michaeline L. Hebron, Nicole M. Desforges, Alexander Franjie, Charbel E.‐H. Moussa   +4 more
doaj   +1 more source

X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B

Neurobiology of Disease, 2017
X-linked Dystonia-Parkinsonism (XDP) is a progressive neurodegenerative disease involving the loss of medium spiny neurons within the striatum. An XDP-specific haplotype has been identified, consisting of seven sequence variants which cluster around the ...
Christine A. Vaine, David Shin, Christina Liu, William T. Hendriks, Jyotsna Dhakal, Kyle Shin, Nutan Sharma, D. Cristopher Bragg   +7 more
doaj   +1 more source

Minimal parkinsonism in the elderly is associated with striatal dopamine loss and pontine structural damage

, 2020
Introduction: To investigate whether neurodegeneration underlying Parkinson's disease (PD) accounts for a substantial proportion of cases of minimal parkinsonism in the elderly.
이양현, 이필휴, 손영호, 유한수, 정석종, 예병석   +5 more
core   +1 more source

The Current State of Parkinsonism in West Africa: A Systematic Review

Parkinson's Disease, 2021
Parkinsonism is one of the most common neurodegenerative diseases among the elderly. Africa is experiencing an increasing burden of age-related conditions including parkinsonism.
Jude T. Quarshie, Esther N. Mensah, Osbourne Quaye, Anastasia R. Aikins   +3 more
doaj   +1 more source