Results 191 to 200 of about 61,853 (265)

Expanding the Spectrum of <i>BCAP31</i>-Associated Diseases: Early-Onset Parkinson Disease. [PDF]

Neurol Genet
Ishiguro M, Funayama M, Park DH, Hatano T, Nakazato T, Luo Y, Osawa M, Li Y, Yoshino H, Hattori N, Kanai K.   +10 more
europepmc   +1 more source

Has Inequity Faced by Young Australians With Disability Changed Since the Turn of the Century?

Australian Journal of Social Issues, EarlyView.
ABSTRACT Despite the introduction of various policies aimed at promoting equality for people with disability since Australia ratified the Convention on the Rights of People with Disabilities (CRPD) in 2008, there has been little evaluation regarding the extent of change in inequity since then.
Asha Parkinson, Joanne Arciuli, Eric Emerson, Sally Robinson, Sally Chance, Gerry Redmond   +5 more
wiley   +1 more source

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism. [PDF]

Ann Neurol
Ono D, Sekiya H, Maier AR, Graff-Radford NR, Wszolek ZK, Dickson DW.   +5 more
europepmc   +1 more source

Associations Between Multiple Chemosensory Dysfunction and Cognition

International Forum of Allergy &Rhinology, EarlyView.
Key Points This study supports the association between chemosensory dysfunction and cognition. We introduce methods of assessing trigeminal function with the Medoc TSA‐II thermoprobe. Our results identify an association between subjective trigeminal dysfunction and cognition.
Michelle Yu, Stephanie M. Horton, Tiffany Chen, Shaun A. Nguyen, Zachary M. Soler, Rodney J. Schlosser   +5 more
wiley   +1 more source

Deep brain stimulation in <i>VPS13C</i>-associated Parkinson's disease: a longitudinal case study. [PDF]

Clin Park Relat Disord
Sumikura H, Tani N, Yoshino H, Hattori N, Sakaguchi M.   +4 more
europepmc   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

Animal Models and Experimental Medicine, EarlyView.
We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin, Zichu Fu, Xuanxuan Zou, Senmao Chai, Jingjing Weng, Puqing Wang, Xiaodong Sun, Ming Sang   +7 more
wiley   +1 more source

Frontal ataxia: a frequent but underrecognized disorder in the spectrum of ataxias. [PDF]

Arq Neuropsiquiatr
Cassarotti B, Bonilha PAAM, Nunes TEM, Coutinho L, Camargo CHF, Teive HAG.   +5 more
europepmc   +1 more source