Results 291 to 300 of about 435,882 (385)

Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization

Advanced Science, EarlyView.
Molecular glues that stabilize protein–protein interactions are challenging to identify. Here, hydrogen‐deuterium exchange mass spectrometry can show and reveal gluing mechanisms that vary between protein binding partners. Abstract Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions.
Danielle F. Kay, Hadeeqa G. Raza, Richard G. Doveston, Aneika C. Leney   +3 more
wiley   +1 more source

A case of schizophrenia with Parkinson's disease: Reduced dopamine transporter binding in unilateral striatum and normal uptake pattern of 123I-MIBG myocardial scintigraphy. [PDF]

PCN Rep
Wada K, Oga K, Minao N, Sugita T.
europepmc   +1 more source

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

The Effect of Immersion Technology on the Quality of Life in Older Adults: A Systematic Review

AGING MEDICINE, EarlyView.
Immersive technologies, especially virtual reality (VR), significantly improve the quality of life for older adults by enhancing physical health, cognitive function, and psychological well‐being. These technologies can be adapted to meet individual needs, making them an effective tool for addressing the challenges of aging.
Solmaz Sohrabei, Vahideh Zolfaghari, Seyed Jafar Ehsanzadeh   +2 more
wiley   +1 more source

Correction to "TRIM25 mutation (p.C168*), coding for an E3 ubiquitin ligase, is a cause of early-onset autosomal dominant dementia with amyloid load and Parkinsonism." [PDF]

Alzheimers Dement
europepmc   +1 more source

Dissecting the Phenotypic Spectrum and Complexity of Movement Disorders in 22q11.2 Deletion Syndrome. [PDF]

Eur J Neurol
Reyes NGD, Grippe T, Callister M, Abkur T, Villanueva EQ, Heung T, Chen R, Boot E, Bassett AS, Lang AE.   +9 more
europepmc   +1 more source

Test-Retest Reliability and Minimal Detectable Change on Balance and Ambulation Tests, the 36-Item Short-Form Health Survey, and the Unified Parkinson Disease Rating Scale in People With Parkinsonism

Physical Therapy, 2008
T. Steffen, M. Seney
semanticscholar   +1 more source

A Versatile Near‐Infrared Fluorescent Probe for Fast Assessment of Lysosomal Status via a Large Multimodal Model

Aggregate, EarlyView.
Herein, we report a quinolinium‐based fluorescent probe, PA‐2, for near‐infrared super‐resolution imaging of lysosomal dynamics. Building on this, we next introduce a novel approach leveraging a large multimodal model (LMM), an advanced artificial intelligence tool, for automated image interpretation.
Rui Chen, Eugene Lee, Yuxin Wang, Aditya Yadav, Minling Zhong, Pragti, Yujie Sun, Jiajie Diao   +7 more
wiley   +1 more source

Temporomandibular Joint Dislocation in Patients With Parkinsonism: A Report of Two Cases. [PDF]

Cureus
Hayashi K, Maeda A, Suzuki A, Nakaya Y, Sato M, Takaku N, Miura T, Kobayashi Y.   +7 more
europepmc   +1 more source

Supramolecular Probe for Monitoring Lysosomal Ferritinophagy to Facilitate the Early Diagnosis of Parkinson's Disease

Aggregate, EarlyView.
A supramolecular fluorescent probe, TPE‐4B/4Q[7], was designed to target lysosomes. The restriction of intramolecular rotation effect mediated by Q[7] enhances the fluorescence of TPE‐4B/4Q[7], enabling selective detection of Fe3+ with a detection limit of 1.23 × 10⁻⁶ M.
Shiqin Zhou, Bo Xiao, Jiamin Chen, Jinming Zhu, Xia Ran, Zuoji Liu, Chaozhong Li, Li Wang, Xinai Cui, Rong Li, Guangwei Feng, Jian Feng   +11 more
wiley   +1 more source