Results 301 to 310 of about 450,934 (396)

MRI Epicenters Differentiate Spatiotemporal Patterns of Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
A connectivity‐based MRI epicenter model identifies two Parkinson's disease subtypes: subtype 1 with infratentorial‐dominant epicenters, severe motor symptoms, and rapid progression; and subtype 2 with supratentorial‐dominant epicenters with mild progression.
Xiaojie Duanmu, Zihao Zhu, Jiaqi Wen, Jianmei Qin, Qianshi Zheng, Weijin Yuan, Yingni Jin, Nan Lu, Lu Wang, Cheng Zhou, Tao Guo, Haoting Wu, Chenqing Wu, Ziyi Zhu, Lifang Wang, Jingwen Chen, Jingjing Wu, Bingting Zhu, Yuelin Fang, Yaping Yan, Baorong Zhang, Minming Zhang, Xiaojun Guan, Xiaojun Xu   +23 more
wiley   +1 more source

Intrathecal chemotherapy for ciltacabtagene autoleucel-associated movement and neurocognitive toxicity. [PDF]

Blood Adv
Kelly K, Cooperrider JH, Bishop MR, Kosuri S, Jakubowiak A, Derman BA.   +5 more
europepmc   +1 more source

Dissecting the Molecular Determinants of α‐synuclein Phase Separation and Condensate Aging: The Pivotal Role of β‐Sheet‐Rich Motifs

Advanced Science, EarlyView.
Through multiscale simulations and experimental approaches, the molecular determinants of α‐synuclein phase separation and condensate aging, which are linked to Parkinson's disease, are uncovered. Seven motifs are identified with high β‐sheet propensity in monomeric α‐synuclein and increasing β‐sheet tendencies during condensation and pre ...
Yiming Tang, Jitao Wen, Zhongyuan Yang, Yifei Yao, Shaoshuai He, Jiyuan Zeng, Xuewei Dong, Qin Qiao, Yun Zhou, Sarah Perrett, Si Wu, Guanghong Wei   +11 more
wiley   +1 more source

Hemichorea as the sole clinical manifestation of spinocerebellar ataxia type 8: a case report. [PDF]

BMC Neurol
Kobayashi M.
europepmc   +1 more source

Photobiomodulation Strengthens Muscles via Its Dual Functions in Gut Microbiota

Advanced Science, EarlyView.
Non‐invasive photobiomodulation therapy (PBMT) enhances muscle endurance by rewiring the gut‐muscle axis. PBMT preserves gut epithelial integrity and enriches beneficial anaerobes, driving metabolites such as butyrate, spermidine, and L‐carnitine that supercharge mitochondrial energy in skeletal muscles.
Prabhat Upadhyay, Asmita Banstola, Brijesh Bhayana, Mei X. Wu   +3 more
wiley   +1 more source

Parkinson's Disease as Illness Anxiety Disorder: A Rare Case Report. [PDF]

Clin Case Rep
Fatahi R, Khooshab MS, Sadatakhavi SF, Ziyaei A, Bidaki R.   +4 more
europepmc   +1 more source

A Single‐Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration

Advanced Science, EarlyView.
Herein, guanidinium‐modified calix[5]arene (GC5AY) is developed featuring small size, positive charge, and desirable amphiphilicity, that can efficiently traverse the nasal mucosal barrier for brain drug delivery. Additionally, possessing inherent therapeutic functions, GC5AY can thus serve as a single‐molecule pleuripotent scaffold for multi‐target ...
Jian‐Mei Gao, Wen‐Bo Li, Na‐Na Chen, Yang Yi, Ze‐Han Wang, Xian Chen, Yang‐Yang Zhao, Ze‐Li Yuan, Jie Gao, Yu‐Chen Pan, Dong‐Sheng Guo, Qi‐Hai Gong   +11 more
wiley   +1 more source

Movement Disorders in Toxoplasmosis: A Systematic Review. [PDF]

Tremor Other Hyperkinet Mov (N Y)
Garg RK, Pandey S, Agarwal M, Singhal S.
europepmc   +1 more source

Accurate Generation of Conformational Ensembles for Intrinsically Disordered Proteins with IDPFold

Advanced Science, EarlyView.
In brief: IDPFold predicts the conformational ensembles of intrinsically disordered proteins (IDPs) from their amino acid sequences. The atomic structures generated by IDPFold offer crucial insights into the intricate relationship between IDP structures and their diverse biological functions.2 Abstract Intrinsically disordered proteins (IDPs) play ...
Junjie Zhu, Zhengxin Li, Zhuoqi Zheng, Bo Zhang, Bozitao Zhong, Jie Bai, Xiaokun Hong, Taifeng Wang, Ting Wei, Jianyi Yang, Hai‐Feng Chen   +10 more
wiley   +1 more source

Cognitive Decline in Parkinsonism: From Clinical Phenotypes to the Genetic Background. [PDF]

Biomedicines
Koros C, Stanitsa E, Angelopoulou E, Papageorgiou SG, Stefanis L.   +4 more
europepmc   +1 more source