Results 341 to 350 of about 435,882 (385)
Some of the next articles are maybe not open access.
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.
Science, 1983Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4 ...
Hansen J N Van +25 more
semanticscholar +1 more source
Genetics of Parkinson’s disease and parkinsonism
Expert Review of Neurotherapeutics, 2007The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased ...
David J Nicholl +2 more
openaire +3 more sources
Genetics of Parkinson's disease and parkinsonism
Annals of Neurology, 2006AbstractUntil 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of several genes that derive from the loci given the nomenclature PARK1‐PARK12 (OMIM 168600).
Andrew B. Singleton +4 more
openaire +3 more sources
Pain in atypical parkinsonism, vascular parkinsonism, and Parkinson’s disease
Neurological Sciences, 2022Pain is a common symptom in Parkinson's disease (PD) and is considered a pre-motor symptom suggesting sensory involvement in the pre-motor stage. Pain in other parkinsonian disorders such as atypical parkinsonism and vascular parkinsonism (VP) has been investigated in only a few studies.
Young Hee Sung, Suk Yun Kang
openaire +2 more sources
Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism
Movement Disorders, 2018Although several studies have suggested that abnormalities in gut microbiota may play a critical role in the pathogenesis of PD, data are still extremely heterogeneous.
M. Barichella +15 more
semanticscholar +1 more source
Changing views of the pathophysiology of Parkinsonism
Movement Disorders, 2019Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia) have a long history and primarily model the consequences of dopamine loss in the basal ganglia on the function of the basal ganglia/thalamocortical circuit(s ...
T. Wichmann
semanticscholar +1 more source
Reversal of experimental parkinsonism by lesions of the subthalamic nucleus.
Science, 1990Although it is known that Parkinson's disease results from a loss of dopaminergic neurons in the substantia nigra, the resulting alterations in activity in the basal ganglia responsible for parkinsonian motor deficits are still poorly characterized ...
H. Bergman, T. Wichmann, M. DeLong
semanticscholar +1 more source
Identification of parkinsonism and Parkinson's disease
Drugs of Today, 2002Parkinson's disease is a common movement disorder associated with considerable disability. The clinical syndrome of parkinsonism is based on the presence of core clinical features of rest tremor, bradykinesia, rigidity and impaired postural reflexes or gait.
openaire +3 more sources
Seminars in Neurology, 2016
Parkinsonism is a clinical syndrome, which is characterized by bradykinesia, rigidity, rest tremor, and postural instability. Idiopathic Parkinson disease (PD) is the most common cause of this syndrome, though there are several other important etiologies that must be considered. These include the atypical Parkinsonian disorders multiple system atrophy (
Adrienne M, Keener, Yvette M, Bordelon
openaire +2 more sources
Parkinsonism is a clinical syndrome, which is characterized by bradykinesia, rigidity, rest tremor, and postural instability. Idiopathic Parkinson disease (PD) is the most common cause of this syndrome, though there are several other important etiologies that must be considered. These include the atypical Parkinsonian disorders multiple system atrophy (
Adrienne M, Keener, Yvette M, Bordelon
openaire +2 more sources
James Parkinson: Parkinson's Disease
Journal of Perioperative Practice, 2013Parkinson's disease is a condition that anyone with a modicum of medical knowledge can recognise in the street - as indeed how it was studied by James Parkinson himself. Its three characteristic features are: 1. Increase in the tone of the voluntary muscles (rigidity). 2. Slowness of movement (bradykinesis). 3.
openaire +2 more sources