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Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features
International Journal of Environmental Research and Public Health, 2015 Manganese (Mn) is an essential trace element necessary for physiological processes that support development, growth and neuronal function. Secondary to elevated exposure or decreased excretion, Mn accumulates in the basal ganglia region of the brain and ...
Gunnar Kwakye +2 more
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Genetics of Parkinson's disease and parkinsonism
Annals of Neurology, 2006AbstractUntil 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of several genes that derive from the loci given the nomenclature PARK1‐PARK12 (OMIM 168600).
Andrew B. Singleton +4 more
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Pain in atypical parkinsonism, vascular parkinsonism, and Parkinson’s disease
Neurological Sciences, 2022Pain is a common symptom in Parkinson's disease (PD) and is considered a pre-motor symptom suggesting sensory involvement in the pre-motor stage. Pain in other parkinsonian disorders such as atypical parkinsonism and vascular parkinsonism (VP) has been investigated in only a few studies.
Young Hee Sung, Suk Yun Kang
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Vascular parkinsonism—characteristics, pathogenesis and treatment
Nature Reviews Neurology, 2015Amos D Korczyn
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Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism
Movement Disorders, 2018Although several studies have suggested that abnormalities in gut microbiota may play a critical role in the pathogenesis of PD, data are still extremely heterogeneous.
M. Barichella +15 more
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Changing views of the pathophysiology of Parkinsonism
Movement Disorders, 2019Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia) have a long history and primarily model the consequences of dopamine loss in the basal ganglia on the function of the basal ganglia/thalamocortical circuit(s ...
T. Wichmann
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Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism
Neurobiology of Disease, 2013 David N Hauser
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Seminars in Neurology, 2016
Parkinsonism is a clinical syndrome, which is characterized by bradykinesia, rigidity, rest tremor, and postural instability. Idiopathic Parkinson disease (PD) is the most common cause of this syndrome, though there are several other important etiologies that must be considered. These include the atypical Parkinsonian disorders multiple system atrophy (
Adrienne M, Keener, Yvette M, Bordelon
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Parkinsonism is a clinical syndrome, which is characterized by bradykinesia, rigidity, rest tremor, and postural instability. Idiopathic Parkinson disease (PD) is the most common cause of this syndrome, though there are several other important etiologies that must be considered. These include the atypical Parkinsonian disorders multiple system atrophy (
Adrienne M, Keener, Yvette M, Bordelon
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Identification of parkinsonism and Parkinson's disease
Drugs of Today, 2002Parkinson's disease is a common movement disorder associated with considerable disability. The clinical syndrome of parkinsonism is based on the presence of core clinical features of rest tremor, bradykinesia, rigidity and impaired postural reflexes or gait.
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James Parkinson: Parkinson's Disease
Journal of Perioperative Practice, 2013Parkinson's disease is a condition that anyone with a modicum of medical knowledge can recognise in the street - as indeed how it was studied by James Parkinson himself. Its three characteristic features are: 1. Increase in the tone of the voluntary muscles (rigidity). 2. Slowness of movement (bradykinesis). 3.
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