Results 351 to 360 of about 450,934 (396)

Parkinsonism

2010
Parkinsonism is defined by the presence of two or more of tremor at rest, bradykinesia, rigidity, and postural instability. It is a relatively uncommon class of movement disorder in children, but can arise through a variety of pathological processes. Juvenile Parkinson’s disease is a rare neurodegenerative condition with several known causes.
Harvey S. Singer, Jonathan W. Mink, Donald L. Gilbert, Joseph Jankovic   +3 more
openaire   +2 more sources

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Nature Medicine, 2012
Peng Lei, Scott Ayton, David Finkelstein
exaly   +2 more sources

Lisuride in parkinsonism

Neurology, 1981
We studied the actions of lisuride, a dopaminergic ergot derivative, in 20 parkinsonian patients. When the dose was increased gradually, most patients tolerated up to 5 mg daily. Clinical assessment and objective, computer-assisted evaluation revealed improvement in akinesia, rigidity and tremor.
Donald B. Calne, W. K. Stuart, Jerome N. Sanes, G. Gopinathan, C. D. Ward, H. Teravainen, J. M. Dambrosia, Edward V. Evarts   +7 more
openaire   +3 more sources

Parkinsonism

2014
The classic triad of parkinsonism includes bradykinesia (slowness of movement and speech), rigidity (increased resistance of the arms, legs, neck, and torso to passive movement) and tremor (typically in the hands or arms, present at rest, but not with movement).
openaire   +1 more source

Parkinsonism and Parkinson's disease

2002
The diagnosis of PD requires a thorough investigation of the main neurologic signs of the disease, as well as the search for signs that are atypical of PD, which may suggest diferential diagnoses (Quinn, 1995). Several diagnostic criteria for PD have been proposed (see Table 2.3), but even in the most experienced Movement Disorders Clinics, about 10–35%
Marcelo Merello, Sergio E. Starkstein
openaire   +2 more sources

Sphingolipids in the Pathogenesis of Parkinson’s Disease and Parkinsonism

Trends in Endocrinology & Metabolism, 2019
The pathogenic mechanisms underlying Parkinson's disease (PD)/parkinsonism affect mitochondrial and endolysosomal trafficking. The retromer is required to retrieve some proteins from endosomes to the Golgi and plasma membrane. Here, we discuss how retromer-dependent retrieval also affects ceramide metabolism.
Paul C. Marcogliese, Paul C. Marcogliese, Hugo J. Bellen, Guang Lin, Guang Lin, Liping Wang, Liping Wang   +6 more
openaire   +3 more sources

Parkinson's disease.

Clinical evidence, 2002
Around 1% of adults have Parkinson's disease, with a median time of 9 years between diagnosis and death.We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of drug treatments in people with early-stage Parkinson's disease?
Carl E, Clarke, A Peter, Moore
openaire   +7 more sources

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Nature, 1998
T. Kitada, S. Asakawa, N. Hattori, H. Matsumine, Y. Yamamura, S. Minoshima, M. Yokochi, Y. Mizuno, N. Shimizu   +8 more
semanticscholar   +1 more source

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.

Science, 1983
Hansen J N Van, Zandt G R J Law, W. E. Briles, Longen-Ecker F Pazderka, J. S. J. L. Gavora, R F Spencer, Ruth, W E H A Brilei, R K Cole Stone, Science, W K Droege, Miggieno V C A Hala, Ziegler, D. L. D. G. Ewert, W E Gilmour, M V C Vilhelmovb, J R L Maggiano, K. Pink, J Hkla, Eiiv Hartmanovi, M K Simonsen, In Hkla, A. A. E. Benedict, Plenum, I. I. P. C. Doherty, R. M. Zinkernagle   +25 more
semanticscholar   +1 more source

Parkinson's disease, Parkinsonism and aging

Archives of Gerontology and Geriatrics, 2002
NICITA MAURO, Vittorio, BASILE, Giorgio, MENTO A, EPIFANIO A, MARTINO, GABRIELLA, MORGANTE, Letterio   +5 more
openaire   +3 more sources