Results 91 to 100 of about 316,530 (280)

Parking to parks : rethinking parking lot system in Shenzhen

open access: yes, 2015
published_or_final_version ; Architecture ; Master ; Master of Landscape ...
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

USE OF OUTDOOR SPORTS EQUIPMENT IN PARKS: A QUALITATIVE STUDY ON THE PERCEPTIONS OF FEMALE AND MALE USERS [PDF]

open access: yesSportif Bakış Spor ve Eğitim Bilimleri Dergisi, 2018
The use of outdoor sports equipment in parks is increasing day by day. Individuals aim to become fit by doing various physical exercises in these areas.
Neslişah Aktaş Üstün   +2 more
doaj  

Monumental trees and their existence value: the case study of an Italian natural park

open access: yesJournal of Forest Science, 2015
This paper aims to the valuation of the benefits that a local community living in a protected area may perceive with regard to the presence of monumental trees. Financial resources to be destined for protection interventions have been decreasing more and
A. Asciuto   +5 more
doaj   +1 more source

Cruising for parking [PDF]

open access: yesTransport Policy, 2006
Abstract Suppose curb parking is free but all the spaces are occupied, and off-street parking is expensive but immediately available. In this case, you can cruise to find a curb space being vacated by a departing motorist, or pay for off-street parking right away.
openaire   +4 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Spatial Distribution and Quality Status of Open Green Spaces and Parks in Calabar Metropolitan Area, Cross River State, Nigeria

open access: yesStudia Ecologiae et Bioethicae
Urban green areas are often seen in highly developed countries as urban green lungs because of their ability to mediate between man and nature. However, it is not the case in developing countries, where the means of subsistence are considered pivotal ...
Josiah Nwabueze Obiefuna   +3 more
doaj   +1 more source

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