Results 101 to 110 of about 935,385 (269)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
HUMAN SECURITY AGENDA- IDEOLOGICAL BASIS AND DEVELOPMENT IN THE CONTEXT OF CANADIAN FOREIGN POLICY
Pravo, 2016 In accordance with the bases of liberal internationalism, the political moral community can be extended beyond the boundaries of the national state. The presence of the moral dimension is inherent to foreign policy, including a foreign political agenda ...
Dragan Božović
doaj
Cogent Social SciencesThis empirical and theoretical study examines China’s strategic engagement in Africa through a constructivist lens, analyzing how Beijing’s approach to global governance influences the resurgence of leftist ideologies across the continent.
Jani Grey Kasunda
doaj +1 more source
A priori veto power of the president of Poland [PDF]
The a priori power of the president of Poland, lower chamber of parliament (Sejm) and upper chamber of parliament (Senate) in the process of legislation are considered in this paper.
Jacek Mercik
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Public administration of safety of navigation: multi-level challenges and answers
Lex Portus, 2020 The article addresses the advantages and shortcomings of multi-level system of ensuring safety of navigation. The principle of the navigation safety is considered as fundamental determinant of changes in maritime laws and regulations at the international,
Tetiana Plachkova, Oleksandr Avdieiev
doaj +1 more source
Is Leisure a Normal Good? Evidence from the European Parliament [PDF]
Prior to July 2009, salaries of the members of the European Parliament were paid by their home country and there were substantial salary differences between parliamentarians representing different EU countries.
Altindag, Duha T., Mocan, Naci
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source