Results 91 to 100 of about 939,925 (287)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The 43rd Parliament: traits and trends [PDF]
Drawing on the statistical tables featured in the 32nd edition of the Parliamentary Handbook, this paper examines the biographical details of the senators and members of Australia\u27s 43rd Parliament.IntroductionIn recent years, academics and media ...
Martin Lumb
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The European Council [Copenhagen Summit 1978], Copenhagen, 7-8 April 1978 [PDF]
, 1978 Dossier: Conclusions, statement by European Parliament President Emilio Colombo, statement by European Commission President Roy Jenkins, article on Community-Japanese ...
core
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
The Failure of Copenhagen and its consequences for International Relations
Intergenerational Justice Review, 2010 No ...
Marisa Matias
doaj +1 more source
A Question of Parliamentary power: Criminal Law and the Control of Greenhouse Gas Emissions [PDF]
The federal government proposes to impose limits on greenhouse gas emissions by large industrial emitters. But under what authority could Parliament implement the regulations?economic growth and innovation, greenhouse gas emissions, Parliament of Canada,
Peter W. Hogg
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FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Евразийская интеграция: экономика, право, политика, 2019 The article deals with questions of correlation of the international criminal law and the criminal legislation of the Kyrgyz Republic and issues of a subject and object of criminal attack on the persons or establishments using international protection ...
C. Aidarbekov
doaj