Results 61 to 70 of about 17,671 (283)

Lava effusion — A slow fuse for paroxysms at Stromboli volcano? [PDF]

, 2011
International audienceThe 2007 effusive eruption of Stromboli followed a similar pattern to the previous 2002–2003 episode. In both cases, magma ascent led to breaching of the uppermost part of the conduit forming an eruptive fissure that discharged lava
Bonaccorso, A., Boschi, E., Calvari, S., Oppenheimer, Clive, Rivalta, E., Spampinato, L.   +5 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Clinical Case of Newly Diagnosed Hypoglycemic Paroxysm Complicated by Severe Neurological Disorders

Mìžnarodnij Endokrinologìčnij Žurnal, 2013
The paper presents a case of hypoglycemic paroxysm, manifested as epilepsy, in 53-year-old man, suffering from diabetes mellitus type 1, complicated by steatohepatosis following excretory and endocrine pancreatic insufficiency, disorders of renal ...
L.V. Shkala, M.K. Tedeyeva
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Bianca Looks from above the Book: Readings on the Margin of Bruno Schulz’s Ex-Libris for Stanisław Weingarten [PDF]

, 2012
The essay traces correspondences between the elements of the 1919 Pierrot ex-libris and the books from Weingarten’s collection which, with time, included and gave privileged position to the works of Bruno Schulz.
Maszewski Zbigniew
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

The role of cytokines in Plasmodium vivax malaria

Memorias do Instituto Oswaldo Cruz, 1992
The cytokine tumor necrosis factor and other as yet unidentified factor(s) which together mediate the killing of intraerythrocytic malaria parasites are transiently elevated in sera during paroxysms in human Plasmodium vivax infections in non-immunes ...
K. N. Mendis, R. Carter
doaj   +1 more source

Wilkie Collins ノ Basil ニ オケル sensation オ メグッテ 1850ネンダイ ニ オケル センセーション ショウセツ ノ ホウガ [PDF]

, 2008
本論は、1860年代初頭のイギリスにおいて「センセーション小説」と呼ばれる小説の新たなジャンルの一大流行を引き起こした作品である The Woman in White(1859-60)の著者、Wilkie Collins の初期の作品 Basil(1852)に見られる「センセーション小説」的要素を考察するものである。Basil の作品中に sensation という言葉が多用されていることに着目し、当時の生理学的文献における sensation の意味合いを参考にしながら ...
Tomoko Hashino, 橋野 朋子
core   +1 more source