Results 121 to 130 of about 61,342 (229)

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, Volume 293, Issue 15, Page 4680-4703, August 2026.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Association Between Contact Force and Acute Lesion Effectiveness in Focal Pulsed Field Ablation

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 8, Page 1879-1882, August 2026.
ABSTRACT Introduction Pulsed field ablation (PFA), based on irreversible electroporation, is a non‐thermal modality designed to create myocardial lesions while minimizing collateral injury. The determinants of acute lesion effectiveness in humans remain incompletely understood.
Sara Poggi, Nandor Szegedi, Cheryl Teres, Daniel Scherr, Christian Heeger, Gabor Szeplaki, Benjamin Berte, Alexandra Karsai, Teresa Strisciuglio, Giuseppe Stabile   +9 more
wiley   +1 more source

Patient‐Reported Outcome Measures Following Pulsed‐Field Ablation Versus Thermal Ablation of Atrial Fibrillation: The PROMs‐PFA Study

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 8, Page 1685-1698, August 2026.
Pulsed‐field was associated with less early post‐procedural chest pain than thermal ablation. ABSTRACT Background Pulsed‐field ablation (PFA) has transformed atrial fibrillation (AF) ablation, but how the early patient experience compares with thermal techniques remains unclear.
Mark T. Mills, Peter Calvert, Keith Wilson, Zoltan Borbas, Richard Snowdon, Saagar N. Mahida, Reza Ashrafi, Johan Waktare, Simon Modi, Derick Todd, Nathan Denham, Vishal Luther, Dhiraj Gupta   +12 more
wiley   +1 more source

Comparative Efficacy of Continuous Versus Patch ECG Monitoring in Detecting Atrial Fibrillation Recurrence Post Catheter Ablation: Insights From the REAL‐AF Registry

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 8, Page 1775-1785, August 2026.
ABSTRACT Background Effective monitoring of atrial fibrillation (AF) recurrence following catheter ablation is crucial for optimizing patient outcomes. Various monitoring strategies exist, but effectiveness comparisons remain underexplored. Objective This study compares the recurrence of atrial arrhythmias detected by continuous versus patch ECG ...
Chinmaya Mareddy, Yashendra Sethi, Gurpreet Johal, Manasvi Gupta, Joshua Silverstein, Amit Thosani, Paul Zei, Linda Justice, Susan M. Bezenek, Jorge Romero, Mohammad Al Jazayeri, Saumil Oza, Matthew J. Singleton, Charles Te, Matthew Sellers, Jordan Leyton Mange, Sandeep Bansal, Huy Phan, Nicholas Costa, Matthew Sackett, Jose Silva, Julia McHugh, Rich Kuk, Daniela Hincapie‐Tabares, Jose Osorio   +24 more
wiley   +1 more source

Comparison of Spatio‐Temporal Dispersion Electrogram Ablation and Low Voltage Zone Ablation in Patients With Persistent Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 8, Page 1837-1845, August 2026.
This study compared STDE‐guided versus LVZ‐guided ablation beyond PVI in 107 persistent AF patients. At 24 months, the AF‐free survival rate was significantly higher in the STDE group (76.3% vs. 58.4%, p=0.027). STDE ablation independently reduced recurrence risk (HR: 0.29, p=0.004), providing superior clinical efficacy over LVZ ablation.
Yutaro Kaneko, Yoshihisa Naruse, Yuki Tokonami, Kazuki Ito, Taro Narumi, Makoto Sano, Yuichiro Maekawa   +6 more
wiley   +1 more source

Enhanced Risk Stratification of Atrial Fibrillation Detected After Ischemic Stroke and TIA: The Role of Apnoea–Hypopnoea Index and Hypoxic Burden—A Study From the Bern Sleep‐Stroke Registry

Journal of Sleep Research, Volume 35, Issue 4, August 2026.
ABSTRACT Sleep‐disordered breathing is an independent risk factor for stroke and atrial fibrillation. Accurate assessment of atrial fibrillation in stroke patients with sleep‐disordered breathing is crucial for secondary prevention. This study aimed to determine whether combining apnoea–hypopnoea index and hypoxic burden improves risk stratification ...
Xiaoli Yang, Julian Lippert, Irina Filchenko, Christian M. Horvath, Sebastien Baillieul, Corrado Bernasconi, Stefan A. Bauer‐Gambelli, Anne‐Kathrin Brill, David J. Seiffge, Elias Auer, Tobias Reichlin, Urs Fischer, Marcel Arnold, Markus H. Schmidt, Claudio L. A. Bassetti   +14 more
wiley   +1 more source

Repolarization adaptation to rapid change in heart rate in human models – a review

The Journal of Physiology, Volume 604, Issue 16, Page 6675-6690, 15 August 2026.
Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt, Karl‐Jonas Axelsson, Pia Dahlberg, Farzad Vahedi, Gunilla Lundahl, Lennart Gransberg   +5 more
wiley   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, Volume 604, Issue 16, Page 6691-6703, 15 August 2026.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Prognostic Value of Right Ventricular Performance and Left Atrial Mechanical Efficiency in Paroxysmal Atrial Fibrillation. [PDF]

J Cardiovasc Dev Dis
Boulmpou A, Pagourelias E, Zormpas G, Ntelios D, Vassilikos V, Papadopoulos C.   +5 more
europepmc   +1 more source

Sleep Apnea and Paroxysmal Atrial Fibrillation: Diurnal Patterning of Autonomic Dysfunction and Influence of CPAP Therapy. [PDF]

J Arrhythm
Khazaie S, Wang L, Kaffashi F, Sandhu A, Chung MK, Heinzinger CM, Van Wagoner DR, Loparo KA, Walia HK, Bena JF, Mehra R.   +10 more
europepmc   +1 more source