Results 51 to 60 of about 86,213 (145)

Reversible Eltrombopag‐Associated Bone Marrow Fibrosis With Hematologic Recovery After Drug Withdrawal in ASXL1‐Mutated Hypoplastic Myelodysplastic Syndrome: A Case Report

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Hypoplastic myelodysplastic syndrome (MDS) often overlaps clinically with aplastic anemia and frequently involves clonal hematopoiesis. Thrombopoietin receptor agonists (TPO‐RAs), including eltrombopag, are increasingly used to treat cytopenias in hypoplastic marrow failure syndromes; however, their long‐term effects on clonal dynamics and ...
Kyoko Yoshihara, Ikuo Matsuda, Yasuhito Nannya, Mami Samori, Naru Tomigaki, Saki Takahashi, Chisato Ohe, Satoshi Yoshihara   +7 more
wiley   +1 more source

Auto-immune haemolytic anaemia and paroxysmal nocturnal haemoglobinuria red cell 11 abnormality in the same patient [PDF]

, 2018
This report concerns a young Indian woman with idiopathic auto-immune haemolytic anaemia. The erythrocytes repeatedly gave positive tests for the paroxysmal nocturnal haemoglobinuria abnormality, as well as positive antiglobulin tests.
Pudifin, DJ, Jamieson, M, Greig, HBW, Ezekowitz, MD   +3 more
core  

Pegcetacoplan Delivers Real‐World Therapeutic Benefits and Reduces Disease Burden for Patients With Paroxysmal Nocturnal Haemoglobinuria: A Systematic Literature Review of Pegcetacoplan Real‐World Clinical and Patient‐Reported Outcomes

European Journal of Haematology, Volume 117, Issue 4, Page 799-813, October 2026.
ABSTRACT Aims Paroxysmal nocturnal haemoglobinuria (PNH) is an ultra‐rare, acquired, non‐malignant haematological disorder that, if left untreated, can lead to significant morbidity. This systematic literature review (SLR) summarized real‐world evidence (RWE) for pegcetacoplan, a complement 3/3b inhibitor (C3i) available since 2021.
Juan Carlos Vallejo Llamas, Koo Wilson, Zalmai Hakimi, Vikte Lionikaite, Elisabetta Metafuni   +4 more
wiley   +1 more source

Erythrocytes of patients with paroxysmal nocturnal haemoglobinuria acquire resistance to complement attack by purified 20-kD homologous restriction factor

, 1990
SUMMARY A 20-kD homologous restriction factor (HRF20) which is a membrane inhibitor of the terminal stage of human complement action can be detected by the monoclonal antibody IF5, and is deficient on abnormal erythrocytes as well as ...
H OKADA, N OKADA, R HARADA
core   +1 more source

Hemoglobinuria paroxística nocturna: Actualización Paroxysmal nocturnal haemoglobinuria

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2003
La hemoglobinuria paroxística nocturna (HPN) es una enfermedad clonal y adquirida causada por una mutación somática en el gen PIG-A que se encuentra en el cromosoma X y codifica una proteina involucrada en la síntesis del glicosilfosfatidilinositol (GPI),
María Teresa Milanés Roldán, Norma Fernández Delgado, Teresa Fundora Sarraff, Juan Carlos Jaime Facundo, Porfirio Hernández Ramírez   +4 more
doaj  

A Case Report: Autoimmune Haemolytic Anaemia & Paroxysmal Nocturnal Haemoglobinuria Association

Haematology Journal of Bangladesh
Autoimmune haemolytic anaemia (AIHA) and paroxysmal nocturnal haemoglobinuria (PNH) are two distinct causes of haemolytic anaemia. They have different mechanisms that underpin their pathogenesis and, therefore, require different treatment strategies ...
Fatima- Tuz- Zohra, Abu Hasan Rubel, Mohd. Tariqul Islam, Md. Sirazul Islam   +3 more
doaj   +1 more source

The central role of extracellular vesicles in the mechanisms of thrombosis in paroxysmal nocturnal haemoglobinuria: a review

Journal of Extracellular Vesicles, 2014
Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired disorder of the haematopoietic stem cell that makes blood cells more sensitive to the action of complement.
Bérangère Devalet, François Mullier, Bernard Chatelain, Jean-Michel Dogné, Christian Chatelain   +4 more
doaj   +1 more source

Assessment of the Performance of Siemens Scopio Digital Morphology on Bone Marrow Aspirates in Onco‐Hematology

International Journal of Laboratory Hematology, Volume 48, Issue 5, Page 1000-1007, October 2026.
ABSTRACT Objectives Digital morphology (DM) systems assisted by artificial intelligence are increasingly being introduced into hematology laboratories; however, data on their performance in routine clinical practice for bone marrow aspirates (BMA) remain limited.
Gina Zini, John Marra, Elena Rossi, Silvia Bellesi, Nicoletta Pelliccioni, Giuseppe d'Onofrio, Patrizia Chiusolo   +6 more
wiley   +1 more source

Paroxysmal Nocturnal Hemoglobinuria (PNH): A Comprehensive Review

Haematology Journal of Bangladesh
Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired clonal hemopoietic stem cell disorder characterized by complement mediated chronic intravascular haemolysis, bone marrow failure and life-threatening thrombosis.
Muhammad Kamruzzaman
doaj   +1 more source

A Population‐Based Study on Childhood Aplastic Anemia—Incidence, Outcomes, and Health‐Related Quality of Life

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Background Childhood aplastic anemia (AA) is a rare disease, and both the disease itself and its treatment cause significant morbidity. We aimed to determine the contemporary incidence of childhood AA in Finland, to compare the clinical characteristics of AA against inherited bone marrow failure syndromes (IBMFS) and refractory cytopenia of ...
Lauri‐Matti Kulmala, Riitta Niinimäki, Tytti Pokka, Anu Huurre, Liisa Järvelä, Sauli Palmu, Tuuli Pöyhönen, Pauliina Utriainen, Henri Aarnivala   +8 more
wiley   +1 more source