Results 21 to 30 of about 2,525 (118)

Paroxysmal Nocturnal Haemoglobinuria Masquerading as Malaria: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2015
Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare type of acquired Haemolytic anaemia that is described as a triad of acquired intravascular Haemolysis, venous thrombosis and anaemia with pancytopenia sometimes due to bone marrow failure. However the
Archana Dambal, Naren V Nimbal, Shanmukh T Kalsad, K Pramod, M P Madhavaranga   +4 more
doaj   +1 more source

A review of the treatment landscape in paroxysmal nocturnal haemoglobinuria: where are we now and where are we going?

Therapeutic Advances in Rare Disease, 2020
Paroxysmal nocturnal haemoglobinuria (PNH) is an ultra-orphan disease, which until 15 years ago had limited treatment options. Eculizumab, a monoclonal antibody that inhibits C5 in the terminal complement cascade, has revolutionised treatment for this ...
Morag Griffin, Richard Kelly, Alexandra Pike   +2 more
doaj   +1 more source

Thrombosis and paroxysmal nocturnal haemoglobinuria

Thrombosis Update, 2021
Thrombosis is the most common, most feared complication of paroxysmal nocturnal haemoglobinuria (PNH), a striking example of the effect of uncontrolled complement activation and haemolysis on vascular biology and haemostasis.
Jean-Christophe Gris, Mathias Chéa, Florence Guillotin, Mathieu Fortier, Chloé Bourguignon, Éric Mercier, Sylvie Bouvier   +6 more
doaj   +1 more source

Coronary Artery By-Pass Grafting in Patient With Paroxysmal Nocturnal Hemoglobinuria (Case Report)

Общая реаниматология, 2021
Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell disease that presents with haemolytic anaemia, thrombosis and bone marrow failure.
A. Amendola, G. Paternoster, S. P Pascale, R. Nuccorini, M. D'Amora, G. Pittella, R. D'Ascoli, F. Prestipino, G. Luzi, M. Pizzuti   +9 more
doaj   +1 more source

Childhood aplastic anaemia with paroxysmal nocturnal haemoglobinuria clones: A retrospective single-centre study in South Africa

African Journal of Laboratory Medicine, 2022
Background: Paroxysmal nocturnal haemoglobinuria (PNH) clones in children are rare but commonly associated with aplastic anaemia (AA) and myelodysplasia.
Candice L. Hendricks, Ashen Naidoo, Rajendra Thejpal, Nadine Rapiti, Beverley Neethling, Yasmin Goga, Suvarna Buldeo   +6 more
doaj   +1 more source

Paroxysmal nocturnal haemoglobinuria, diagnosis and haematological findings, first report from Iran, model for developing countries

eJHaem, 2022
Since paroxysmal nocturnal haemoglobinuria (PNH) was first described in 1881, the diagnosis and follow‐up patients diagnosed with the illness has remained an area of concern, with several different techniques of varying sensitivity having been described ...
Mohammadali Jahangirpour, Amirali Vahedi, Hamed Baghdadi, Tahereh Madani, Ali Behvarmanesh, Mohammad Alidadi, Mohadese Hashem Boroojerdi, Saba Mohammaei, Peyvand Poopak, Amirhossein Poopak, Gelareh Khosravi Pour, Behzad Poopak   +11 more
doaj   +1 more source

Paroxysmal nocturnal haemoglobinuria: a case presenting with isolated thrombocytopenia

Biotechnology & Biotechnological Equipment, 2016
Paroxysmal nocturnal haemoglobinuria (PNH) is a rare disease characterized by intravascular haemolysis, haemoglobinuria and thrombosis. The present study reported PNH patients presenting with isolated thrombocytopenia.
Mustafa Yilmaz, Beyhan Guvercin, Ceren Konca   +2 more
doaj   +1 more source

Pulmonary embolism in a patient with eltrombopag-treated aplastic anaemia and paroxysmal nocturnal haemoglobinuria clone during COVID-19 pneumonia

Thrombosis Journal, 2022
Thrombosis in patients with thrombocytopenia has several risk factors, both disease-related and treatment-associated. Recently, COVID-19 infection was recognized as an additional risk factor, further complicating the delicate balance between thrombosis ...
Bosi Alessandro, Barcellini Wilma, Fattizzo Bruno   +2 more
doaj   +1 more source

The central role of extracellular vesicles in the mechanisms of thrombosis in paroxysmal nocturnal haemoglobinuria: a review

Journal of Extracellular Vesicles, 2014
Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired disorder of the haematopoietic stem cell that makes blood cells more sensitive to the action of complement.
Bérangère Devalet, François Mullier, Bernard Chatelain, Jean-Michel Dogné, Christian Chatelain   +4 more
doaj   +1 more source

Generalized pulp canal obliteration in a patient on long-term glucocorticoids: a case report and literature review

BMC Oral Health, 2022
Background The calcification of the tooth pulp is a pathological condition that occurs in response to various factors. A uncommon haematological condition known as paroxysmal nocturnal haemoglobinuria (PNH) is characterized by bouts of haemolysis, and it
Ban Jiandong, Zhang Yunxiao, Wang Zuhua, Hou Yan, Geng Shuangshuang, Li Junke, Wang Hongwei, Xu Hua   +7 more
doaj   +1 more source