Results 41 to 50 of about 15,382 (226)

Paroxysmal Nocturnal Hemoglobinuria in Myelofibrosis [PDF]

Blood, 1970
Abstract Ten consecutive patients with myelofibrosis were examined for the following signs of PNH: Ham’s test, the sucrose hemolysis test, low red cell acetylcholinesterase (ACHE) activity and intravascular hemolysis. Two of the patients displayed all these signs and also had clinical symptoms of PNH.
N E, Hansen, S A, Killmann
openaire   +2 more sources

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

Haematologica, 2017
Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are treated with eculizumab, a humanized monoclonal antibody against the terminal complement ...
Xuan Yuan, Eleni Gavriilaki, Jane A. Thanassi, Guangwei Yang, Andrea C. Baines, Steven D. Podos, Yongqing Huang, Mingjun Huang, Robert A. Brodsky   +8 more
doaj   +1 more source

Safety and efficacy of pegcetacoplan in paroxysmal nocturnal hemoglobinuria

Therapeutic Advances in Hematology, 2022
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, hematologic disease characterized by complement-mediated hemolysis, thrombosis, and various degrees of bone marrow dysfunction.
R. Wong
semanticscholar   +1 more source

Paroxysmal nocturnal hemoglobinuria in systemic lupus erythematosus: a case report

Journal of Medical Case Reports, 2011
Introduction Paroxysmal nocturnal hemoglobinuria is an acquired disorder of hemopoiesis and is characterized by recurrent episodes of intravascular hemolysis due to an increased sensitivity to complement-mediated hemolysis.
Nakamura Norio, Sugawara Toshiyuki, Shirato Ken-ichi, Kumasaka Ryuichiro, Nakamura Masayuki, Shimada Michiko, Fujita Takeshi, Murakami Reiichi, Shimaya Yuko, Osawa Hiroshi, Yamabe Hideaki, Okumura Ken   +11 more
doaj   +1 more source

Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine

Haematologica, 2010
Background Clones of glycosylphosphatidylinositol-anchor protein-deficient cells are characteristic in paroxysmal nocturnal hemoglobinuria and are present in about 40–50% of patients with severe aplastic anemia.
Phillip Scheinberg, Michael Marte, Olga Nunez, Neal S. Young   +3 more
doaj   +1 more source

The importance of terminal complement inhibition in paroxysmal nocturnal hemoglobinuria

Therapeutic Advances in Hematology, 2022
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic hematologic disorder associated with inappropriate terminal complement activity on blood cells that can result in intravascular hemolysis (IVH), thromboembolic events (TEs), and organ damage ...
A. Kulasekararaj, R. Brodsky, J. Nishimura, Christopher J. Patriquin, H. Schrezenmeier   +4 more
semanticscholar   +1 more source

Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Hemoglobinuria.

New England Journal of Medicine
BACKGROUND Persistent hemolytic anemia and a lack of oral treatments are challenges for patients with paroxysmal nocturnal hemoglobinuria who have received anti-C5 therapy or have not received complement inhibitors.
R. Peffault de Latour, Alexander Röth, A. Kulasekararaj, Bing Han, P. Scheinberg, Jaroslaw P. Maciejewski, Yasutaka Ueda, C. de Castro, Eros Di Bona, Rong Fu, Li Zhang, Morag Griffin, Saskia M C Langemeijer, J. Panse, H. Schrezenmeier, W. Barcellini, Vitor A Q Mauad, Philippe Schafhausen, S. Tavitian, Eloise Beggiato, L. Chew, A. Gaya, Wei-Han Huang, J. H. Jang, Toshio Kitawaki, Abdullah Kutlar, Rosario Notaro, V. Pullarkat, Jörg Schubert, L. Terriou, Michihiro Uchiyama, Lily Wong Lee Lee, E. Yap, F. Sicre de Fontbrune, L. Marano, F. Alashkar, Shreyans Gandhi, Roochi Trikha, Chen Yang, Hui Liu, Richard J. Kelly, B. Höchsmann, Cécile Kerloeguen, Partha Banerjee, R. Levitch, Rakesh Kumar, Zhixin Wang, Christine Thorburn, Samopriyo Maitra, Shujie Li, Aurelie Verles, M. Dahlke, A. Risitano   +52 more
semanticscholar   +1 more source

Technical advances in flow cytometry-based diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria

Einstein (São Paulo)
Objective: To discuss the implementation of technical advances in laboratory diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria for validation of high-sensitivity flow cytometry protocols. Methods: A retrospective study based on analysis of
Rodolfo Patussi Correia, Laiz Cameirão Bento, Ana Carolina Apelle Bortolucci, Anderson Marega Alexandre, Andressa da Costa Vaz, Daniela Schimidell, Eduardo de Carvalho Pedro, Fabricio Simões Perin, Sonia Tsukasa Nozawa, Cláudio Ernesto Albers Mendes, Rodrigo de Souza Barroso, Nydia Strachman Bacal   +11 more
doaj   +1 more source

Phase 3 randomized COMMODORE 2 trial: Crovalimab versus eculizumab in patients with paroxysmal nocturnal hemoglobinuria naive to complement inhibition

American journal of hematology/oncology
Crovalimab is a novel C5 complement inhibitor that enables rapid and sustained C5 inhibition with subcutaneous, low‐volume self‐administration every 4 weeks.
Alexander Röth, Guangsheng He, Hongyan Tong, Zenghua Lin, Xiaoqin Wang, C. Chai-Adisaksopha, Je-Hwan Lee, A. Brodsky, Chattree Hantaweepant, T. Dumagay, Roberta Demichelis-Gómez, P. Rojnuckarin, Jing Sun, M. Höglund, Jun-Ho Jang, A. Gaya, Fernando Silva, N. Obara, Richard J. Kelly, Leigh Beveridge, Simon Buatois, S. Chebon, Brittany Gentile, Pontus Lundberg, S. Sreckovic, Jun-Ichi Nishimura, A. Risitano, B. Han   +27 more
semanticscholar   +1 more source

Paroxysmal nocturnal hemoglobinuria and pregnancy before the eculizumab era: the French experience

Haematologica, 2011
Background Pregnancy in women with paroxysmal nocturnal hemoglobinuria is rare, with few reports on maternal and fetal mortality rates.Design and Methods A specific questionnaire designed to solicit data on pregnancies in women with paroxysmal nocturnal ...
Sophie de Guibert, Régis Peffault de Latour, Nathalie Varoqueaux, Hélène Labussière, Bernard Rio, Dominique Jaulmes, Jean-Richard Eveillard, Stéphanie Dulucq, Anne-Marie Stoppa, Didier Bouscary, François Girodon, Bernard Bonnotte, Djamila Laskri, Gérard Socié, Thierry Lamy   +14 more
doaj   +1 more source