Results 101 to 110 of about 23,848 (306)

Benign Centrotemporal Spikes in a Female Child with Rolandic Epilepsy: A Case Report

Journal of Clinical and Diagnostic Research
Benign Epilepsy with Centrotemporal Spikes (BECTS), also known as Rolandic epilepsy, is a common epilepsy syndrome that mainly affects children. It is more prevalent during the preschool and school years, with a higher incidence in males (M:F - 1.5:1 ...
Abhiraj Parekar, Ketki Giradkar
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Amiodarone-Induced Hypothyroidism

Кубанский научный медицинский вестник, 2019
Aim: to present a clinical case of amiodarone-induced hypothyroidism in a patient with paroxysmal atrial fi brillation.Results. Before taking amiodarone, the patient suffered from subclinical hypothyroidism. The level of thyroid stimulating hormone (TSH)
Svetlana A. Chepurnenko, Galina V. Shavkuta, Alina D. Nasytko   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Prognostic value of high-resolution electrocardiography parameters, heart rate variability, and QT interval dynamics in patients with chronic heart failure

Кардиоваскулярная терапия и профилактика, 2006
Aim. To study prognostic value of high-resolution electrocardiography (HR-ECG), heart rate variability (HRV), QT interval dispersion and duration parameters, for assessing the risk of chronic heart failure (CHF) decompensation, atrial fibrillation (AF ...
A. E. Radzevich, V. V. Popov, N. A. Bulanova, M. Yu. Knyazeva   +3 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Epicrania fugax combining forward and backward paroxysms in the same patient: the first four cases

Journal of Pain Research, 2017
Johanna Barón-Sánchez,1 Álvaro Gutiérrez-Viedma,2 Marina Ruiz-Piñero,1 Alicia Pérez-Pérez,2 Ángel Luis Guerrero,1,3 María L Cuadrado2,4 1Headache Unit, Department of Neurology, Hospital Cl ...
Barón-Sánchez J, Gutiérrez-Viedma Á, Ruiz-Piñero M, Pérez-Pérez A, Guerrero ÁL, Cuadrado ML   +5 more
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Ablation outcomes and quality of life in patients with atrial flutter and concomitant paroxysmal atrial fibrillation

Heart Vessels and Transplantation
Objective: To compare ablation outcomes and quality of life (QoL) of patients with typical atrial flutter (AFL) and concomitant atrial fibrillation (AF) paroxysms after cavotricuspid isthmus (CTI) ablation alone or combined with pulmonary vein isolation.
Anastasia Aker, Ulyana Chernyaha-Royko, Mykhaylo Sorokivskyy, Borys Kravchuk, Yuriy Ivaniv, Oleg Zharinov   +5 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source