Results 71 to 80 of about 14,675 (263)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Propafenone efficacy in treatment of atrial fibrillation paroxysms: a placebo-controlled study
Российский кардиологический журнал, 2005 In a placebo-controlled study, propafenone efficacy and safety for pharmaceutical cardioversion in atrial fibrillation (AF) paroxysms were studied. The study included 50 patients aged 28-69 years (mean age 53,9+9,7), with AF paroxysms lasting for less ...
Yu. A. Bunin, L. K. Anfalova
doaj
Эпилепсия и пароксизмальные состояния, 2017 The report addresses the causes and diagnostic problems of cryptogenic focal frontal epilepsy. A clinical case of a patient with cryptogenic focal frontal epilepsy is presented. In this patient, epileptic seizures have long been considered as psychogenic
N. V. Chebanenko +7 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Экспериментальная психология, 2015 Memory disorders are a common pathology in children with convulsive paroxysms. The present study tested the hypothesis that the pathology of memory in children with paroxysmal states have quantitative and qualitative specificity.
O.Yu. Shchelkova, D.A. Eremina
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Benign Centrotemporal Spikes in a Female Child with Rolandic Epilepsy: A Case Report
Journal of Clinical and Diagnostic ResearchBenign Epilepsy with Centrotemporal Spikes (BECTS), also known as Rolandic epilepsy, is a common epilepsy syndrome that mainly affects children. It is more prevalent during the preschool and school years, with a higher incidence in males (M:F - 1.5:1 ...
Abhiraj Parekar, Ketki Giradkar
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Экспериментальная психология, 2015 Memory disorders are a common pathology in children with convulsive paroxysms. The present study tested the hypothesis that the pathology of memory in children with paroxysmal states have quantitative and qualitative specificity.
N.G. Turovskaya
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source