Results 141 to 150 of about 39,225 (199)

LEF1/NFE2L3/TACC1 axis activates the AKT-mTOR pathway to promote the progression of esophageal squamous cell carcinoma. [PDF]

J Thorac Dis
Li H, Xu S, Li N, Xu T, Li T, Chen H, Lu Q.   +6 more
europepmc   +1 more source

Single-Nucleotide Polymorphisms in Genes Associated with Mitochondrial and DNA Damage Response Modulate the Risk of Non-Alcoholic Fatty Liver Disease in Humans. [PDF]

Int J Mol Sci
Ziółkowska S, Kosmalski M, Kołodziej Ł, Jarmusz K, Ejsmont M, Pietras T, Jabłkowska A, Jabłkowski M, Szemraj J, Czarny P.   +9 more
europepmc   +1 more source

cGAS/STING-mediated upregulation of NKG2D ligands in LSCs contributes to enhanced sensitivity to NK cells. [PDF]

Front Oncol
Ouyang Y, Qin Y, Zhang Q, Zhu P, Zhu H.
europepmc   +1 more source

Epacadostat and Olaparib Synergistically Inhibit the Growth of BRCA-Proficient Triple-Negative Breast Cancer by Suppressing the Expression of BRCA1 and RAD51. [PDF]

Molecules
Huang L, Yang Y, Duan D, Dai L, Zhai B, Qian B.   +5 more
europepmc   +1 more source

HPF1 regulates the formation of FUS-dependent compartments by PARP1 and PARP2 activation on damaged DNA. [PDF]

Nucleic Acids Res
Singatulina AS, Sukhanova MV, Hamon L, Kutuzov MM, Pastré D, Lavrik OI.   +5 more
europepmc   +1 more source

Core targets of bisphenol A in cervical cancer revealed by network toxicology and molecular docking. [PDF]

Medicine (Baltimore)
Li Y, Zhang W, Tang L, Zhu Y, Dong H, Yang L, Zhao Y.   +6 more
europepmc   +1 more source

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The complex universe of inactive PARP1

Trends in Genetics
Poly(ADP-ribose) polymerase 1 (PARP1) is a crucial member of the PARP family, which modifies targets through ADP-ribosylation and plays key roles in a variety of biological processes.
Ziyi Su
exaly   +4 more sources

Selective PARP1 inhibitors, PARP1-based dual-target inhibitors, PROTAC PARP1 degraders, and prodrugs of PARP1 inhibitors for cancer therapy

Pharmacological Research, 2022
Poly ADP-ribose polymerase (PARP) plays a critical role in many cellular processes such as DNA damage repair, gene transcription and cell apoptosis. Therefore, targeting PARP represents a promising strategy for cancer therapy. To date, numerous small molecule PARP1 inhibitors have been identified, but many of them suffer from limited clinical efficacy ...
Xiaopeng Peng, Wanyi Pan, Weiming Chen   +2 more
exaly   +3 more sources

PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs [PDF]

International Journal of Molecular Sciences, 2017
Poly (ADP-ribose) polymerase 1 (PARP1), the best-studied isoform of the nuclear enzyme PARP family, plays a pivotal role in cellular biological processes, such as DNA repair, gene transcription, and so on. PARP1 has been found to be overexpressed in various carcinomas.
Chao Liang, Fangfei Li, Daogang Guan
exaly   +3 more sources