Results 121 to 130 of about 25,426 (206)

PARP1 expression in breast cancer and effects of its inhibition in preclinical models [PDF]

, 2012
Breast cancer is the main cause of cancer death in women. Improved treatments, prevention programs and earlier detection are reducing the rate of death; however, there is still a high percentage of mortality by this cancer.
García Parra, Jetzabel
core   +1 more source

Arabidopsis DNA repair mutants can integrate Agrobacterium T‐DNA into the plant genome

New Phytologist, EarlyView.
Transient (a) and stable (b) transformation of Arabidopsis thaliana DNA repair/recombination mutants grown under normal light conditions. Summary Agrobacterium transfer DNA (T‐DNA) integration is mediated by plant DNA repair proteins of various nonhomologous end‐joining (NHEJ) pathways.
Lan‐Ying Lee, Yunjia Shen, Yooyoung Kim, Ayako Nishizawa‐Yokoi, Hiroaki Saika, Demi White, Wenying Liao, Stanton B. Gelvin   +7 more
wiley   +1 more source

Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review

Plant Biology, EarlyView.
Benzamides boost crop resilience by inhibiting poly(ADP‐ribose) polymerase (PARP) to enhance stress tolerance and, through their antimicrobial, herbicidal, and insecticidal derivatives, they offer broad protection for sustainable crop improvement. Abstract Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology ...
M. J. Koetle, T. E. Motaung, S. O. Amoo
wiley   +1 more source

Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes

, 2020
The central paradigm of novel therapeutic approaches in cancer therapy is identifying and targeting molecular biomarkers. One such target is the nuclear DNA repair enzyme Poly-(ADP ribose) polymerase 1 (PARP1).
Mottaghy, Felix, Mottaghy, Felix M., Beheshti, Mohsen, Morgenroth, Agnieszka, Ramya Ambur Sankaranarayanan, Sankaranarayanan, Ramya Ambur, Agnieszka Morgenroth, Weber, Wolfgang, Susanne Kossatz, Wolfgang Weber, Felix M. Mottaghy, Kossatz, Susanne, Mohsen Beheshti   +12 more
core   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, Volume 16, Issue 7, Page 1370-1386, July 2026.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

The Chemical Regulatory Landscape of Biomolecular Condensates

Aggregate, Volume 7, Issue 7, July 2026.
Chemical regulation of biomolecular phase separation offers a unique opportunity to bridge molecular‐level chemistry with emergent cellular organization. Chemically informed strategies for controlling condensate condensates through chemically tractable parameters such as interaction valency, solvent quality, and molecular crowding provides a unifying ...
Di Liu, Xin Zhang
wiley   +1 more source

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

Nature Communications, 2019
Atrial fibrillation (AF) is accompanied by a detrimental loss of functional cardiomyocytes. Here, Zhang et al. show that AF-induced cardiomyocyte dysfunction is a consequence of DNA damage-mediated PARP1 activation, which leads to depletion of NAD+ and ...
Deli Zhang, Xu Hu, Jin Li, Jia Liu, Luciënne Baks-te Bulte, Marit Wiersma, Noor-ul-Ann Malik, Denise M. S. van Marion, Marziyeh Tolouee, Femke Hoogstra-Berends, Eva A. H. Lanters, Arie M. van Roon, Antoine A. F. de Vries, Daniël A. Pijnappels, Natasja M. S. de Groot, Robert H. Henning, Bianca J. J. M. Brundel   +16 more
doaj   +1 more source

Nicotinamide Reverses the Warburg Effect in CHO Cell Culture

Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1902-1915, July 2026.
ABSTRACT The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey, Ayca Cankorur‐Cetinkaya, Luigi Grassi, Annie J. Harwood‐Stamper, Jonathan Welsh, Ryte Poskute, Kasia Kozakowska‐McDonnell, Cleo Kontoravdi   +7 more
wiley   +1 more source

How Banf1 Functions to Inhibit the Activity of PARP1

This thesis explores the interaction between two key proteins, Banf1 and PARP1, which play crucial roles in DNA repair. Using advanced techniques like mass photometry, spectroscopy, and electron microscopy, the research reveals how Banf1 regulates PARP1's activity by binding to its catalytic domain.
openaire   +2 more sources