Results 1 to 10 of about 32,646 (215)

Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury

Redox Biology, 2021
Poly(ADP-ribose) polymerase 1 (PARP1) has a major regulatory role in cardiovascular disease. However, inhibiting PARP1 activity does not significantly improve clinical outcomes of cardiovascular disease, which suggests that the regulatory mechanism of ...
Naijin Zhang, Ying Zhang, Boquan Wu, Shaojun Wu, Shilong You, Saien Lu, Jingwei Liu, Xinyue Huang, Jiaqi Xu, Liu Cao, Yingxian Sun   +10 more
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Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting

Advanced Science, 2022
Poly (ADP‐ribose) polymerase 1 (PARP1) plays a fundamental role in DNA repair and gene expression. Excessive PARP1 hyperactivation, however, has been associated with cell death. PARP1 and/or its activity are dysregulated in the immune and central nervous
Yan Wang, David Pleasure, Wenbin Deng, Fuzheng Guo   +3 more
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THE PEPTIDOGLYCAN FRACTION ENRICHED WITH MURAMYL PENTAPEPTIDE FROM Lactobacillus bulgaricus INHIBITS GLIOBLASTOMA U373MG CELL MIGRATION CAPABILITY AND UPREGULATES PARP1 AND NF-kB LEVELS [PDF]

Biotechnologia Acta, 2020
Peptidoglycan is a universal component of bacterial walls that exerts various biological activities, including tumoricidal effect. Anti-cancer effect of various peptidoglycan fractions and their derivates is different.
V. S. Nedzvetsky, C. A. Agca, G. Baydas
doaj   +1 more source

A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells

Cell Reports
Summary: Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress PARP1 catalytic activity but also prolong its association to damaged chromatin.
Petar-Bogomil Kanev, Sylvia Varhoshkova, Irina Georgieva, Maria Lukarska, Dilyana Kirova, Georgi Danovski, Stoyno Stoynov, Radoslav Aleksandrov   +7 more
doaj   +3 more sources

Pyridazine Based Compounds with PARP-1 Inhibitory Activity

Archives of Pharmaceutical Sciences Ain Shams University, 2023
Pyridazine-containing compounds have been identified as potent PARP1 inhibitors. The PARP is a family of enzymes essential for many cellular processes such as DNA repair, genomic stability, and apoptosis, also known as poly(ADP-ribose) synthetases and ...
Norhan A. Abdelrahman, Mai Y. Jaballah, Ahmed A. Al-Karmalawy , Khaled A. M. Abouzid   +3 more
doaj   +1 more source

Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging

iScience, 2023
Summary: PARP1 contributes to genome architecture and DNA damage repair through its dynamic association with chromatin. PARP1 and PARP2 (PARP1/2) recognize damaged DNA and recruit the DNA repair machinery.
Jyothi Mahadevan, Asmita Jha, Johannes Rudolph, Samuel Bowerman, Domenic Narducci, Anders S. Hansen, Karolin Luger   +6 more
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In Silico Investigation of the Molecular Mechanism of PARP1 Inhibition for the Treatment of BRCA-Deficient Cancers

Molecules, 2023
The protein PARP1, which plays a crucial role in DNA repair processes, is an attractive target for cancer therapy, especially for BRCA-deficient cancers.
Fengqin Yan, Zhenfu Fu, Guo Li, Zhiguo Wang   +3 more
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PARP1 might enhance the therapeutic effect of tetrahydroxystilbene glucoside in traumatic brain injury via inhibition of Ras/JNK signalling pathway

Folia Neuropathologica, 2020
Trauma is the main cause of death for people aged 1-45, and among them, traumatic brain injury (TBI) is the major condition, which causes over 50,000 deaths each year and costs over 80 billion per year.
Yiqiang Cao, Yu Chen, Fei Wang, Yonggang Wang, Jiang Long   +4 more
doaj   +1 more source

Trial watch: STING agonists in cancer therapy

OncoImmunology, 2020
Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from several pattern recognition receptors, most of which sense ectopic DNA ...
Julie Le Naour, Laurence Zitvogel, Lorenzo Galluzzi, Erika Vacchelli, Guido Kroemer   +4 more
doaj   +1 more source

A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells. [PDF]

PLoS ONE, 2016
Poly(ADP-ribose) polymerase 1 (PARP1) is a key player in DNA repair, genomic stability and cell survival and it emerges as a highly relevant target for cancer therapies.
Andrea Buchfellner, Larisa Yurlova, Stefan Nüske, Armin M Scholz, Jacqueline Bogner, Benjamin Ruf, Kourosh Zolghadr, Sophie E Drexler, Guido A Drexler, Stefanie Girst, Christoph Greubel, Judith Reindl, Christian Siebenwirth, Tina Romer, Anna A Friedl, Ulrich Rothbauer   +15 more
doaj   +1 more source