Redox Biology, 2021 Poly(ADP-ribose) polymerase 1 (PARP1) has a major regulatory role in cardiovascular disease. However, inhibiting PARP1 activity does not significantly improve clinical outcomes of cardiovascular disease, which suggests that the regulatory mechanism of ...
Jingwei Liu, Liu Cao, Yingxian Sun
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The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Nature Reviews Molecular Cell Biology, 2017 Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer.
Arnab Ray Chaudhuri +2 more
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Advanced Science, 2022 Poly (ADP‐ribose) polymerase 1 (PARP1) plays a fundamental role in DNA repair and gene expression. Excessive PARP1 hyperactivation, however, has been associated with cell death. PARP1 and/or its activity are dysregulated in the immune and central nervous
David Pleasure +2 more
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PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends
CellDNA double-strand breaks (DSBs) are repaired at DSB sites. How DSB sites assemble and how broken DNA is prevented from separating is not understood. Here we uncover that the synapsis of broken DNA is mediated by the DSB sensor protein poly(ADP-ribose ...
Radoslav Aleksandrov +2 more
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Vascular Protection of Poly(ADP-ribose) Polymerase Inhibitors in the Combination Therapy With Vascular Endothelial Growth Factor Signaling Pathway Inhibitors [PDF]
Reviews in Cardiovascular MedicineThe Poly(ADP-ribose) polymerase (PARP) family comprises seventeen members that catalyze poly- or mono- adenosine diphosphate (ADP)-ribosylation, a pivotal post-translational modification regulating a wide array of cellular processes, including ...
Jie Ma +8 more
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Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance The activity of PARP1 was increased in the skeletal muscle of aged humans, mice, and Drosophila. The knockdown of PARP1, specifically in muscle, extended the lifespan of Drosophila.
Shanshan Guo +2 more
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FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells
Nature CommunicationsThe effectiveness of poly (ADP-ribose) polymerase inhibitors (PARPi) in creating single-stranded DNA gaps and inducing sensitivity requires the FANCJ DNA helicase. Yet, how FANCJ relates to PARP1 inhibition or trapping, which contribute to PARPi toxicity,
Ke Cong +8 more
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Cell ReportsSummary: Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress PARP1 catalytic activity but also prolong its association to damaged chromatin.
Petar-Bogomil Kanev +7 more
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PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
EMBO ReportsPoly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity – poly(ADP-ribosyl)ation (PARylation). The enrichment of DNA repair proteins at sites of DNA
Christopher Chin Sang +10 more
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THE PEPTIDOGLYCAN FRACTION ENRICHED WITH MURAMYL PENTAPEPTIDE FROM Lactobacillus bulgaricus INHIBITS GLIOBLASTOMA U373MG CELL MIGRATION CAPABILITY AND UPREGULATES PARP1 AND NF-kB LEVELS [PDF]
Biotechnologia Acta, 2020 Peptidoglycan is a universal component of bacterial walls that exerts various biological activities, including tumoricidal effect. Anti-cancer effect of various peptidoglycan fractions and their derivates is different.
V. S. Nedzvetsky, C. A. Agca, G. Baydas
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