Results 21 to 30 of about 39,225 (199)
PAR recognition by PARP1 regulates DNA‐dependent activities and independently stimulates catalytic activity of PARP1 [PDF]
The FEBS Journal, 2021 Poly(ADP‐ribosyl)ation is predominantly catalyzed by Poly(ADP‐ribose) polymerase 1 (PARP1) in response to DNA damage, mediating the DNA repair process to maintain genomic integrity. Single‐strand (SSB) and double‐strand (DSB) DNA breaks are bona fide stimulators of PARP1 activity. However, PAR‐mediated PARP1 regulation remains unexplored.
Waghela Deeksha +2 more
openaire +3 more sources
PARP inhibition: PARP1 and beyond [PDF]
Nature Reviews Cancer, 2010 Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide ...
Michèle, Rouleau +4 more
openaire +2 more sources
SPINDOC binds PARP1 to facilitate PARylation [PDF]
Nature Communications, 2021 AbstractSPINDOC is tightly associated with the histone H3K4me3 effector protein SPIN1. To gain a better understanding of the biological roles of SPINDOC, we identified its interacting proteins. Unexpectedly, SPINDOC forms two mutually exclusive protein complexes, one with SPIN1 and the other with PARP1.
Fen Yang +8 more
openaire +3 more sources
Polish Journal of Pathology, 2020 Molecular next gene sequencing was used to evaluate mutations in 409 common mutated cancer-related genes in malignant mesothelioma of tunica vaginalis testis (MMTVT) of 81-year-old man.
Artur Kowalik +7 more
doaj +1 more source
A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells. [PDF]
PLoS ONE, 2016 Poly(ADP-ribose) polymerase 1 (PARP1) is a key player in DNA repair, genomic stability and cell survival and it emerges as a highly relevant target for cancer therapies.
Andrea Buchfellner +15 more
doaj +1 more source
Transcriptional Roles of PARP1 in Cancer [PDF]
Molecular Cancer Research, 2014 Abstract Poly (ADP-ribose) polymerase-1 (PARP1) is an abundant, ubiquitously expressed NAD+-dependent nuclear enzyme that has prognostic value for a multitude of human cancers. PARP1 activity serves to poly (ADP-ribose)-ylate the vast majority of known client proteins and affects a number of cellular and biologic outcomes, by mediating ...
Matthew J, Schiewer, Karen E, Knudsen
openaire +2 more sources
The Role of Nicotinamide in Cancer Chemoprevention and Therapy
Biomolecules, 2020 Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of nicotinamide-adenine dinucleotide (NAD+) which regulates cellular energy metabolism.
Ilias P. Nikas +2 more
doaj +1 more source
Single-particle analysis of full-length human poly(ADP-ribose) polymerase 1
Biophysics and Physicobiology, 2019 PolyADP-ribosylation (PARylation) is a posttranslational modification that is involved in the various cellular functions including DNA repair, genomic stability, and transcriptional regulation.
Kenichi Kouyama +5 more
doaj +1 more source
PARP1 Inhibitors: Antitumor Drug Design [PDF]
Acta Naturae, 2015 The poly (ADP-ribose) polymerase 1 (PARP1) enzyme is one of the promising molecular targets for the discovery of antitumor drugs. PARP1 is a common nuclear protein (1-2 million molecules per cell) serving as a sensor for DNA strand breaks. Increased PARP1 expression is sometimes observed in melanomas, breast cancer, lung cancer, and other neoplastic ...
MALYUCHENKO N.V. +4 more
openaire +3 more sources
Cancer Research, 2016 Abstract Purpose of study. An attractive strategy to improve antitumor treatments is to inflict cytotoxic DNA damage with chemotherapy, and then impede DNA repair by molecular targeting. TR is a new drug characterized by a peculiar mechanism of action: TR traps DNA repair machinery leading to DNA damage, particularly in BRCA1/2-deficient
Ymera Pignochino +11 more
openaire +6 more sources