Results 21 to 30 of about 32,646 (215)
Infection and Drug Resistance, 2023 Qirong Lu,1,* Wantong Han,1,* Defeng Wen,1,* Pu Guo,1 Yu Liu,1 Zhongyuan Wu,1 Shulin Fu,1 Chun Ye,1 Xu Wang,2 Yinsheng Qiu1 1Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering ...
Lu Q +9 more
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Transcriptional Roles of PARP1 in Cancer [PDF]
Molecular Cancer Research, 2014 Abstract Poly (ADP-ribose) polymerase-1 (PARP1) is an abundant, ubiquitously expressed NAD+-dependent nuclear enzyme that has prognostic value for a multitude of human cancers. PARP1 activity serves to poly (ADP-ribose)-ylate the vast majority of known client proteins and affects a number of cellular and biologic outcomes, by mediating ...
Matthew J, Schiewer, Karen E, Knudsen
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PARP1 promotes the progression of hepatocellular carcinoma by regulating expression of POU2F2 [PDF]
Zhongguo aizheng zazhiBackground and purpose: Hepatocellular carcinoma (HCC) is a major disease seriously threatening human health. Poly (ADP-ribose) polymerase-1 (PARP1) is an enzyme that catalyzes poly ADP-ribosylation.
WEN Ziqiang, LAN Junliang, ZHOU Bo, XU Qiwei
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Polish Journal of Pathology, 2020 Molecular next gene sequencing was used to evaluate mutations in 409 common mutated cancer-related genes in malignant mesothelioma of tunica vaginalis testis (MMTVT) of 81-year-old man.
Artur Kowalik +7 more
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The Role of Nicotinamide in Cancer Chemoprevention and Therapy
Biomolecules, 2020 Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of nicotinamide-adenine dinucleotide (NAD+) which regulates cellular energy metabolism.
Ilias P. Nikas +2 more
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Single-particle analysis of full-length human poly(ADP-ribose) polymerase 1
Biophysics and Physicobiology, 2019 PolyADP-ribosylation (PARylation) is a posttranslational modification that is involved in the various cellular functions including DNA repair, genomic stability, and transcriptional regulation.
Kenichi Kouyama +5 more
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Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli. [PDF]
PLoS Genetics, 2012 Poly(ADP-ribose) polymerase 1 (PARP1), a nuclear protein, utilizes NAD to synthesize poly(AD-Pribose) (pADPr), resulting in both automodification and the modification of acceptor proteins.
Ernest K Boamah +4 more
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PARP inhibition: PARP1 and beyond [PDF]
Nature Reviews Cancer, 2010 Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide ...
Michèle, Rouleau +4 more
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Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation
Scientific Reports, 2022 Poly(ADP-ribose) polymerase-1 (PARP1), a fundamental DNA repair enzyme, is known to regulate β cell death, replication, and insulin secretion. PARP1 knockout (KO) mice are resistant to diabetes, while PARP1 overactivation contributes to β cell death ...
Nidheesh Dadheech +4 more
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Biomedicines, 2022 Oxidative stress contributes to numerous diseases, including cancer. CSB is an ATP-dependent chromatin remodeler critical for oxidative stress relief. PARP1 is the major sensor for DNA breaks and fundamental for efficient single-strand break repair.
Robert J. Lake +2 more
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