Results 21 to 30 of about 6,651 (207)

Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development

Cells, 2023
Poly(ADP-ribose) polymerase-1 (PARP1) binds DNA lesions to catalyse poly(ADP-ribosyl)ation (PARylation) using NAD+ as a substrate. PARP1 plays multiple roles in cellular activities, including DNA repair, transcription, cell death, and chromatin ...
Tatiana Kamaletdinova, Wen Zong, Pavel Urbánek, Sijia Wang, Mara Sannai, Paulius Grigaravičius, Wenli Sun, Zahra Fanaei-Kahrani, Aswin Mangerich, Michael O. Hottiger, Tangliang Li, Zhao-Qi Wang   +11 more
doaj   +1 more source

A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells. [PDF]

PLoS ONE, 2016
Poly(ADP-ribose) polymerase 1 (PARP1) is a key player in DNA repair, genomic stability and cell survival and it emerges as a highly relevant target for cancer therapies.
Andrea Buchfellner, Larisa Yurlova, Stefan Nüske, Armin M Scholz, Jacqueline Bogner, Benjamin Ruf, Kourosh Zolghadr, Sophie E Drexler, Guido A Drexler, Stefanie Girst, Christoph Greubel, Judith Reindl, Christian Siebenwirth, Tina Romer, Anna A Friedl, Ulrich Rothbauer   +15 more
doaj   +1 more source

PAR recognition by PARP1 regulates DNA‐dependent activities and independently stimulates catalytic activity of PARP1 [PDF]

The FEBS Journal, 2021
Poly(ADP‐ribosyl)ation is predominantly catalyzed by Poly(ADP‐ribose) polymerase 1 (PARP1) in response to DNA damage, mediating the DNA repair process to maintain genomic integrity. Single‐strand (SSB) and double‐strand (DSB) DNA breaks are bona fide stimulators of PARP1 activity. However, PAR‐mediated PARP1 regulation remains unexplored.
Waghela Deeksha, Suman Abhishek, Eerappa Rajakumara   +2 more
openaire   +3 more sources

PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease - Fig 6

, 2020
(A) T. cruzi-induced EvDNAis oxidized. NEv and TEv were isolated from normal and T. cruzi-infected Raw Mφ (triplicate samples per group), and from normal and chronically infected WT and Parp1-/- mice (n = 10 mice per group).
Nisha Jain Garg (6834830), Subhadip Choudhuri (8741193)   +1 more
core   +1 more source

Analysis of mutations of PARP1, RNF213, PAX8, KMT2C, MTRR in malignant mesothelioma of testicular tunica vaginalis testis

Polish Journal of Pathology, 2020
Molecular next gene sequencing was used to evaluate mutations in 409 common mutated cancer-related genes in malignant mesothelioma of tunica vaginalis testis (MMTVT) of 81-year-old man.
Artur Kowalik, Andrzej Wincewicz, Sebastian Zięba, Wojciech Baran, Janusz Kopczyński, Mariusz Koda, Stanisław Sulkowski, Stanisław Goźdź   +7 more
doaj   +1 more source

PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease - Fig 2

, 2020
(A-F) Parp1-/-primary Mφ exhibit decreased cytokines’ expression in response to TEv stimulation. Supernatants of Raw 264.7 Mφ incubated with media only or T. cruzi were used to purify NEvRAW and TEvRAW, respectively. Primary bone-marrow Mφ (WT or Parp1-/-
Nisha Jain Garg (6834830), Subhadip Choudhuri (8741193)   +1 more
core   +1 more source

DNA translocase levels at damaged replication forks are rescued by the introduction of PARP1 in PARP1-KO cells.

, 2022
(A)-(D) Representative images of HLTF, SHPRH, ZRANB3, and SMARCAL1 PLA foci, respectively, in PARP1-KO, PAPR1-rescue, and PARP1-K893I expressing T24 cells. The pLNCX vectors carrying wild-type PARP1 or PARP1-K893I mutant, respectively, were packaged into
Jia-Lin Shiu (14253587), Chen-Syun Ku (14253581), Han-Wen Zhang (7839116), Peter Chi (176651), Wen-Tai Chiu (525239), Yen-Chih Ho (14253578), Song-Bin Chang (14253596), Yi-Zhen Jiang (14253590), Siang-Sheng Tsai (14253584), Hui Emmanuela Miriam (14253593), Yen-Tzu Chen (11087124), Hungjiun Liaw (216472), Che-Hung Shen (14253599), Kyungjae Myung (206169)   +13 more
core   +2 more sources

Resveratrol Preconditioning Regulates PARP1 to Induce Ischemic Tolerance Against PARP1-Mediated Neuronal Death [PDF]

, 2023
Stroke, or cerebral ischemia (CI), remains a leading cause of mortality, however, available therapeutics are limited. A major contributor to the pathophysiology of CI is oxidative stress (OS), a condition that facilitates oxidative DNA lesions and ...
Jackson, Charles
core   +3 more sources

18β-Glycyrrhetinic Acid Alleviates P. multocida-Induced Vascular Endothelial Inflammation by PARP1-Mediated NF-κB and HMGB1 Signalling Suppression in PIEC Cells

Infection and Drug Resistance, 2023
Qirong Lu,1,* Wantong Han,1,* Defeng Wen,1,* Pu Guo,1 Yu Liu,1 Zhongyuan Wu,1 Shulin Fu,1 Chun Ye,1 Xu Wang,2 Yinsheng Qiu1 1Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering ...
Lu Q, Han W, Wen D, Guo P, Liu Y, Wu Z, Fu S, Ye C, Wang X, Qiu Y   +9 more
doaj  

The Role of Nicotinamide in Cancer Chemoprevention and Therapy

Biomolecules, 2020
Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of nicotinamide-adenine dinucleotide (NAD+) which regulates cellular energy metabolism.
Ilias P. Nikas, Stavroula A. Paschou, Han Suk Ryu   +2 more
doaj   +1 more source