Results 31 to 40 of about 32,646 (215)
PD-L1 Predicts Poor Prognosis in Surgically Resected Limited Stage Small-Cell Lung Cancer
Cancer Management and Research, 2020 Xiao Fu,1,* Zhiyan Liu,2,* Luochengling Xiang,1 Mengjie Liu,1 Xiaoqiang Zheng,1 Jingjing Wang,1 Na Liu,1 Huan Gao,1 Aimin Jiang,1 Yujuan Yang,3 Xuan Liang,1 Zhiping Ruan,1 Tao Tian,1 Yu Yao1 1Department of Medical Oncology, The First Affiliated Hospital ...
Fu X +13 more
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PARP1 Inhibitors: Antitumor Drug Design [PDF]
Acta Naturae, 2015 The poly (ADP-ribose) polymerase 1 (PARP1) enzyme is one of the promising molecular targets for the discovery of antitumor drugs. PARP1 is a common nuclear protein (1-2 million molecules per cell) serving as a sensor for DNA strand breaks. Increased PARP1 expression is sometimes observed in melanomas, breast cancer, lung cancer, and other neoplastic ...
MALYUCHENKO N.V. +4 more
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Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. [PDF]
PLoS Genetics, 2009 Recently, the nuclear protein known as Poly (ADP-ribose) Polymerase1 (PARP1) was shown to play a key role in regulating transcription of a number of genes and controlling the nuclear sub-organelle nucleolus. PARP1 enzyme is known to catalyze the transfer
Elena Kotova +2 more
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Frontiers in Cell and Developmental Biology, 2021 Myocardial ischemia–reperfusion injury (MIRI), characterized by post-ischemic cardiomyocytes death and reperfusion myocardial damage, is a lethal yet unresolved complication in the treatment of acute myocardial infarction (AMI).
Yifeng Xu +7 more
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Cancer Management and Research, 2020 Mingzhe Zhu,1,* Lei Yang,2,* Xin Wang3 1Department of Obstetrics and Gynecology, Jilin Medical College Affiliated Hospital, Jilin City, Jilin Province 132011, People’s Republic of China; 2Department of Medical Clinic, Yuhuangding Hospital, Yantai ...
Zhu M, Yang L, Wang X
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Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
Cell Stress, 2023 The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease.
Maria Castedo +2 more
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
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Cancer Research, 2016 Abstract Purpose of study. An attractive strategy to improve antitumor treatments is to inflict cytotoxic DNA damage with chemotherapy, and then impede DNA repair by molecular targeting. TR is a new drug characterized by a peculiar mechanism of action: TR traps DNA repair machinery leading to DNA damage, particularly in BRCA1/2-deficient
Ymera Pignochino +11 more
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Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. [PDF]
PLoS Pathogens, 2018 Latent membrane protein 1 (LMP1) is the major transforming protein of Epstein-Barr virus (EBV) and is critical for EBV-induced B-cell transformation in vitro. Poly(ADP-ribose) polymerase 1 (PARP1) regulates accessibility of chromatin, alters functions of
Michael Hulse +5 more
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PARP1 inhibition protects mice against Japanese encephalitis virus infection
Cell Reports, 2023 Summary: Japanese encephalitis (JE) is a vector-borne viral disease that causes acute encephalitis in children. Although vaccines have been developed against the JE virus (JEV), no effective antiviral therapy exists.
Perumal Arumugam Desingu +10 more
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