Results 31 to 40 of about 39,225 (199)

PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

eLife, 2020
It is being increasingly appreciated that the immunomodulatory functions of PARP1 inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi possess both PARP1 inhibition and PARP1 trapping activities.
Chiho Kim, Xu-Dong Wang, Yonghao Yu
doaj   +1 more source

The Expanding Universe of PARP1-Mediated Molecular and Therapeutic Mechanisms

Molecules and Cells, 2022
SUMMARY ADP-ribosylation (ADPRylation) is a posttranslational modification of proteins catalyzed by ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (e.g., PARP1 and PARP2). Historically, studies of ADPRylation and PARPs have focused on DNA
Dan-Xia Huang, W. Kraus
semanticscholar   +1 more source

PARP1: Liaison of Chromatin Remodeling and Transcription

Cancers, 2022
Poly(ADP-ribosyl)ation (PARylation) is a covalent post-translational modification and plays a key role in the immediate response of cells to stress signals. Poly(ADP-ribose) polymerase 1 (PARP1), the founding member of the PARP superfamily, synthesizes long and branched polymers of ADP-ribose (PAR) onto acceptor proteins, thereby modulating their ...
Wen Zong, Yamin Gong, Wenli Sun, Tangliang Li, Zhao-Qi Wang   +4 more
openaire   +2 more sources

18β-Glycyrrhetinic Acid Alleviates P. multocida-Induced Vascular Endothelial Inflammation by PARP1-Mediated NF-κB and HMGB1 Signalling Suppression in PIEC Cells

Infection and Drug Resistance, 2023
Qirong Lu,1,* Wantong Han,1,* Defeng Wen,1,* Pu Guo,1 Yu Liu,1 Zhongyuan Wu,1 Shulin Fu,1 Chun Ye,1 Xu Wang,2 Yinsheng Qiu1 1Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering ...
Lu Q, Han W, Wen D, Guo P, Liu Y, Wu Z, Fu S, Ye C, Wang X, Qiu Y   +9 more
doaj  

Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation

Scientific Reports, 2022
Poly(ADP-ribose) polymerase-1 (PARP1), a fundamental DNA repair enzyme, is known to regulate β cell death, replication, and insulin secretion. PARP1 knockout (KO) mice are resistant to diabetes, while PARP1 overactivation contributes to β cell death ...
Nidheesh Dadheech, Abhay Srivastava, Rashmi G. Shah, Girish M. Shah, Sarita Gupta   +4 more
doaj   +1 more source

Dynamic Interplay between Cockayne Syndrome Protein B and Poly(ADP-Ribose) Polymerase 1 during Oxidative DNA Damage Repair

Biomedicines, 2022
Oxidative stress contributes to numerous diseases, including cancer. CSB is an ATP-dependent chromatin remodeler critical for oxidative stress relief. PARP1 is the major sensor for DNA breaks and fundamental for efficient single-strand break repair.
Robert J. Lake, Rabeya Bilkis, Hua-Ying Fan   +2 more
doaj   +1 more source

Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli. [PDF]

PLoS Genetics, 2012
Poly(ADP-ribose) polymerase 1 (PARP1), a nuclear protein, utilizes NAD to synthesize poly(AD-Pribose) (pADPr), resulting in both automodification and the modification of acceptor proteins.
Ernest K Boamah, Elena Kotova, Mikael Garabedian, Michael Jarnik, Alexei V Tulin   +4 more
doaj   +1 more source

PD-L1 Predicts Poor Prognosis in Surgically Resected Limited Stage Small-Cell Lung Cancer

Cancer Management and Research, 2020
Xiao Fu,1,* Zhiyan Liu,2,* Luochengling Xiang,1 Mengjie Liu,1 Xiaoqiang Zheng,1 Jingjing Wang,1 Na Liu,1 Huan Gao,1 Aimin Jiang,1 Yujuan Yang,3 Xuan Liang,1 Zhiping Ruan,1 Tao Tian,1 Yu Yao1 1Department of Medical Oncology, The First Affiliated Hospital ...
Fu X, Liu Z, Xiang L, Liu M, Zheng X, Wang J, Liu N, Gao H, Jiang A, Yang Y, Liang X, Ruan Z, Tian T, Yao Y   +13 more
doaj  

PARP1: A comprehensive review of its mechanisms, therapeutic implications and emerging cancer treatments.

Biochimica et biophysica acta. Reviews on cancer
The Poly (ADP-ribose) polymerase-1 (PARP1) enzyme is involved in several signalling pathways related to homologous repair (HR), base excision repair (BER), and non-homologous end joining (NHEJ).
Carlota J F Conceição, Elin Moe, P. Ribeiro, M. Raposo   +3 more
semanticscholar   +1 more source

PARP1 associates with R-loops to promote their resolution and genome stability

Nucleic Acids Research, 2023
PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate their resolution.
Natalie Laspata, Parminder Kaur, Sofiane Y Mersaoui, D. Muoio, Z. Liu, Maxwell Bannister, Hai Dang Nguyen, C. Curry, J. Pascal, G. Poirier, Hong Wang, J. Masson, Elise Fouquerel   +12 more
semanticscholar   +1 more source