Results 31 to 40 of about 6,651 (207)
Mechanistic insights into the HPF1/PARP1 complex [PDF]
, 2022 ADP-ribosylation is a vital post-translational modification associated with a large range of processes including DNA damage repair, transcription, replication, mitosis, inflammation and cell death.
Zobel, Florian Franz Henning
core +1 more source
, 2020 Trypanosoma cruzi (T. cruzi) is the etiological agent of Chagas cardiomyopathy. In the present study, we investigated the role of extracellular vesicles (Ev) in shaping the macrophage (Mφ) response in progressive Chagas disease (CD). We purified T. cruzi
Nisha Jain Garg (6834830) +3 more
core +1 more source
α‐Aminophosphonates as Potential PARP1 Inhibitors [PDF]
, 2020 ADP‐ribosyl transferase member 1 (PARP1) is primarily known for its involvement in signaling DNA damage repair mechanisms within a cell. PARP1 inhibitors are used currently for the management of breast cancer (BRCA) gene mutated breast and ovarian ...
Stephanie S. Schweiker +11 more
core +1 more source
Transcriptional Roles of PARP1 in Cancer [PDF]
Molecular Cancer Research, 2014 Abstract Poly (ADP-ribose) polymerase-1 (PARP1) is an abundant, ubiquitously expressed NAD+-dependent nuclear enzyme that has prognostic value for a multitude of human cancers. PARP1 activity serves to poly (ADP-ribose)-ylate the vast majority of known client proteins and affects a number of cellular and biologic outcomes, by mediating ...
Matthew J, Schiewer, Karen E, Knudsen
openaire +2 more sources
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
eLife, 2020 It is being increasingly appreciated that the immunomodulatory functions of PARP1 inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi possess both PARP1 inhibition and PARP1 trapping activities.
Chiho Kim, Xu-Dong Wang, Yonghao Yu
doaj +1 more source
Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli. [PDF]
PLoS Genetics, 2012 Poly(ADP-ribose) polymerase 1 (PARP1), a nuclear protein, utilizes NAD to synthesize poly(AD-Pribose) (pADPr), resulting in both automodification and the modification of acceptor proteins.
Ernest K Boamah +4 more
doaj +1 more source
Single-particle analysis of full-length human poly(ADP-ribose) polymerase 1
Biophysics and Physicobiology, 2019 PolyADP-ribosylation (PARylation) is a posttranslational modification that is involved in the various cellular functions including DNA repair, genomic stability, and transcriptional regulation.
Kenichi Kouyama +5 more
doaj +1 more source
PARP inhibition: PARP1 and beyond [PDF]
Nature Reviews Cancer, 2010 Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide ...
Michèle, Rouleau +4 more
openaire +2 more sources
Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation
Scientific Reports, 2022 Poly(ADP-ribose) polymerase-1 (PARP1), a fundamental DNA repair enzyme, is known to regulate β cell death, replication, and insulin secretion. PARP1 knockout (KO) mice are resistant to diabetes, while PARP1 overactivation contributes to β cell death ...
Nidheesh Dadheech +4 more
doaj +1 more source
Biomedicines, 2022 Oxidative stress contributes to numerous diseases, including cancer. CSB is an ATP-dependent chromatin remodeler critical for oxidative stress relief. PARP1 is the major sensor for DNA breaks and fundamental for efficient single-strand break repair.
Robert J. Lake +2 more
doaj +1 more source