Results 41 to 50 of about 6,651 (207)
PARP1 promotes the progression of hepatocellular carcinoma by regulating expression of POU2F2 [PDF]
Zhongguo aizheng zazhiBackground and purpose: Hepatocellular carcinoma (HCC) is a major disease seriously threatening human health. Poly (ADP-ribose) polymerase-1 (PARP1) is an enzyme that catalyzes poly ADP-ribosylation.
WEN Ziqiang, LAN Junliang, ZHOU Bo, XU Qiwei
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PD-L1 Predicts Poor Prognosis in Surgically Resected Limited Stage Small-Cell Lung Cancer
Cancer Management and Research, 2020 Xiao Fu,1,* Zhiyan Liu,2,* Luochengling Xiang,1 Mengjie Liu,1 Xiaoqiang Zheng,1 Jingjing Wang,1 Na Liu,1 Huan Gao,1 Aimin Jiang,1 Yujuan Yang,3 Xuan Liang,1 Zhiping Ruan,1 Tao Tian,1 Yu Yao1 1Department of Medical Oncology, The First Affiliated Hospital ...
Fu X +13 more
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PARP1-Targeted Radiotherapies [PDF]
, 2020 Poly-ADP-ribosylation reactions were first reported by Chambon in 1963 as enzymatic activity that increases incorporation of ATP in the presence of nicotinamide mononucleotide.
Jannetti, Stephen
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PARP1 Inhibitors: Antitumor Drug Design [PDF]
Acta Naturae, 2015 The poly (ADP-ribose) polymerase 1 (PARP1) enzyme is one of the promising molecular targets for the discovery of antitumor drugs. PARP1 is a common nuclear protein (1-2 million molecules per cell) serving as a sensor for DNA strand breaks. Increased PARP1 expression is sometimes observed in melanomas, breast cancer, lung cancer, and other neoplastic ...
MALYUCHENKO N.V. +4 more
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Cancer Research, 2016 Abstract Purpose of study. An attractive strategy to improve antitumor treatments is to inflict cytotoxic DNA damage with chemotherapy, and then impede DNA repair by molecular targeting. TR is a new drug characterized by a peculiar mechanism of action: TR traps DNA repair machinery leading to DNA damage, particularly in BRCA1/2-deficient
Ymera Pignochino +11 more
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Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. [PDF]
PLoS Genetics, 2009 Recently, the nuclear protein known as Poly (ADP-ribose) Polymerase1 (PARP1) was shown to play a key role in regulating transcription of a number of genes and controlling the nuclear sub-organelle nucleolus. PARP1 enzyme is known to catalyze the transfer
Elena Kotova +2 more
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Frontiers in Cell and Developmental Biology, 2021 Myocardial ischemia–reperfusion injury (MIRI), characterized by post-ischemic cardiomyocytes death and reperfusion myocardial damage, is a lethal yet unresolved complication in the treatment of acute myocardial infarction (AMI).
Yifeng Xu +7 more
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Imaging poly(ADP-ribose) polymerase-1 (PARP1) in vivo with 18F-labeled brain penetrant positron emission tomography (PET) ligand [PDF]
Poly(ADP-ribose) polymerase 1 (PARP1) is a multifunctional protein involved in diverse cellular functions, notably DNA damage repair. Pharmacological inhibition of PARP1 holds potential therapeutic benefits for various pathologies.
Richard S. , Van +23 more
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The multifunctional protein YB-1 potentiates PARP1 activity and decreases the efficiency of PARP1 inhibitors [PDF]
Oncotarget, 2018 Y-box-binding protein 1 (YB-1) is a multifunctional cellular factor overexpressed in tumors resistant to chemotherapy. An intrinsically disordered structure together with a high positive charge peculiar to YB-1 allows this protein to function in almost all cellular events related to nucleic acids including RNA, DNA and poly(ADP-ribose) (PAR).
Alemasova, Elizaveta E. +4 more
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Cancer Management and Research, 2020 Mingzhe Zhu,1,* Lei Yang,2,* Xin Wang3 1Department of Obstetrics and Gynecology, Jilin Medical College Affiliated Hospital, Jilin City, Jilin Province 132011, People’s Republic of China; 2Department of Medical Clinic, Yuhuangding Hospital, Yantai ...
Zhu M, Yang L, Wang X
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