Results 41 to 50 of about 39,225 (199)

The multifunctional protein YB-1 potentiates PARP1 activity and decreases the efficiency of PARP1 inhibitors [PDF]

Oncotarget, 2018
Y-box-binding protein 1 (YB-1) is a multifunctional cellular factor overexpressed in tumors resistant to chemotherapy. An intrinsically disordered structure together with a high positive charge peculiar to YB-1 allows this protein to function in almost all cellular events related to nucleic acids including RNA, DNA and poly(ADP-ribose) (PAR).
Alemasova, Elizaveta E., Naumenko, Konstantin N., Kurgina, Tatyana A., Anarbaev, Rashid O., Lavrik, Olga I.   +4 more
openaire   +2 more sources

PARP1 promotes the progression of hepatocellular carcinoma by regulating expression of POU2F2 [PDF]

Zhongguo aizheng zazhi
Background and purpose: Hepatocellular carcinoma (HCC) is a major disease seriously threatening human health. Poly (ADP-ribose) polymerase-1 (PARP1) is an enzyme that catalyzes poly ADP-ribosylation.
WEN Ziqiang, LAN Junliang, ZHOU Bo, XU Qiwei
doaj   +3 more sources

PARP1-Erk synergism in proliferating cells [PDF]

Oncotarget, 2018
A synergism between PARP1 and phosphorylated Erk mediating IEG (immediate early gene) expression has been recently reported in cerebral neurons and cardiomyocytes. Stimulation induced PARP-Erk synergism was required for IEG expression underlying synaptic plasticity and long-term memory acquisition during learning.
Visochek, Leonid, Cohen-Armon, Malka
openaire   +2 more sources

Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

Cell Stress, 2023
The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease.
Maria Castedo, Antoine Lafarge, Guido Kroemer   +2 more
doaj   +1 more source

Sp1 Targeted PARP1 Inhibition Protects Cardiomyocytes From Myocardial Ischemia–Reperfusion Injury via Downregulation of Autophagy

Frontiers in Cell and Developmental Biology, 2021
Myocardial ischemia–reperfusion injury (MIRI), characterized by post-ischemic cardiomyocytes death and reperfusion myocardial damage, is a lethal yet unresolved complication in the treatment of acute myocardial infarction (AMI).
Yifeng Xu, Boqian Wang, Xiaoxiao Liu, Yunfei Deng, Yanqi Zhu, Feng Zhu, Yanyan Liang, Hongli Li   +7 more
doaj   +1 more source

The PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models

Genome Medicine
Poly (ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitors (PARPi) are targeted therapies approved for homologous recombination repair (HRR)-deficient breast, ovarian, pancreatic, and prostate cancers.
A. Herencia-Ropero, A. Llop-Guevara, A. Staniszewska, Joanna Domènech-Vivó, Eduardo García-Galea, A. Moles‐Fernández, F. Pedretti, Heura Domenech, O. Rodríguez, M. Guzman, E. Arenas, H. Verdaguer, F. Calero-Nieto, S. Talbot, L. Tobalina, Elisabetta Leo, Alan Lau, P. Nuciforo, R. Dienstmann, T. Macarulla, Joaquin Arribas, O. Díez, S. Gutiérrez‐Enríquez, J. Forment, M. O’Connor, M. Albertella, J. Balmaña, V. Serra   +27 more
semanticscholar   +1 more source

Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling

Molecules and Cells, 2023
SUMMARY PARP1, an established anti-cancer target that regulates many cellular pathways, including DNA repair signaling, has been intensely studied for decades as a poly(ADP-ribosyl)transferase. Although recent studies have revealed the prevalence of mono-
E. Longarini, Helen Dauben, C. Locatelli, Anne R. Wondisford, Rebecca Smith, Charlotte Muench, Andreas Kolvenbach, M. L. Lynskey, A. Pope, J. Bonfiglio, Eva Pinto Jurado, R. Fajka‐Boja, T. Colby, M. Schuller, I. Ahel, Gyula Timinszky, Roderick J. O’Sullivan, S. Huet, I. Matic   +18 more
semanticscholar   +1 more source

Radioiodinated PARP1 tracers for glioblastoma imaging [PDF]

EJNMMI Research, 2015
Although the understanding of the genetic and molecular basis of cancer has advanced significantly over the past several decades, imaging and treatment options for glioblastoma patients have been more limited (N Engl J Med 359:492-507, 2008). This is in part due to difficulties in diagnosing this disease early, combined with its diffuse, infiltrative ...
Salinas, Beatriz, Irwin, Christopher P., Kossatz, Susanne, Bolaender, Alexander, Chiosis, Gabriela, Pillarsetty, Nagavarakishore, Weber, Wolfgang A., Reiner, Thomas   +7 more
openaire   +2 more sources

Metformin Induces a Caspase 3-Unrelated Apoptosis in Human Colorectal Cancer Cell Lines HCT116 and SW620

Cancer Management and Research, 2023
Bustanur Rosidi,1 Diana Priyatno,1 Teguh Pribadi Putra,1 Irawan Yusuf1,2 1Division of Proteomics, Mochtar Riady Institute for Nanotechnology and Medical Science Group, University of Pelita Harapan, Tangerang, Banten, Indonesia; 2Faculty of Medicine ...
Rosidi B, Priyatno D, Putra TP, Yusuf I
doaj  

Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. [PDF]

PLoS Genetics, 2009
Recently, the nuclear protein known as Poly (ADP-ribose) Polymerase1 (PARP1) was shown to play a key role in regulating transcription of a number of genes and controlling the nuclear sub-organelle nucleolus. PARP1 enzyme is known to catalyze the transfer
Elena Kotova, Michael Jarnik, Alexei V Tulin   +2 more
doaj   +1 more source