Results 61 to 70 of about 55,025 (289)

In Vitro Evaluation of PARP1 Inhibitor Olaparib-Cyanine Dye Conjugate for the Treatment of Glioblastoma. [PDF]

ChemMedChem
Inhibition of DNA damage repair is a common mechanism to induce cancer cell death and, therefore, to treat cancers such as breast, prostate and ovarian cancer. This approach, although very attractive, has not been feasible for treating brain tumours due to the stringent structural features necessary for pharmaceutical agents to cross the blood–brain ...
Dumo C, Faheem, Choi PJ, Pederson NJ, Liu Y, Dragunow M, Park TI, Diehl KL, Jose J.   +8 more
europepmc   +2 more sources

PD-L1 Predicts Poor Prognosis in Surgically Resected Limited Stage Small-Cell Lung Cancer

Cancer Management and Research, 2020
Xiao Fu,1,* Zhiyan Liu,2,* Luochengling Xiang,1 Mengjie Liu,1 Xiaoqiang Zheng,1 Jingjing Wang,1 Na Liu,1 Huan Gao,1 Aimin Jiang,1 Yujuan Yang,3 Xuan Liang,1 Zhiping Ruan,1 Tao Tian,1 Yu Yao1 1Department of Medical Oncology, The First Affiliated Hospital ...
Fu X, Liu Z, Xiang L, Liu M, Zheng X, Wang J, Liu N, Gao H, Jiang A, Yang Y, Liang X, Ruan Z, Tian T, Yao Y   +13 more
doaj  

PARP1: A comprehensive review of its mechanisms, therapeutic implications and emerging cancer treatments.

Biochimica et biophysica acta. Reviews on cancer
The Poly (ADP-ribose) polymerase-1 (PARP1) enzyme is involved in several signalling pathways related to homologous repair (HR), base excision repair (BER), and non-homologous end joining (NHEJ).
Carlota J F Conceição, Elin Moe, P. Ribeiro, M. Raposo   +3 more
semanticscholar   +1 more source

The multifunctional protein YB-1 potentiates PARP1 activity and decreases the efficiency of PARP1 inhibitors [PDF]

Oncotarget, 2018
Y-box-binding protein 1 (YB-1) is a multifunctional cellular factor overexpressed in tumors resistant to chemotherapy. An intrinsically disordered structure together with a high positive charge peculiar to YB-1 allows this protein to function in almost all cellular events related to nucleic acids including RNA, DNA and poly(ADP-ribose) (PAR).
Alemasova, Elizaveta E., Naumenko, Konstantin N., Kurgina, Tatyana A., Anarbaev, Rashid O., Lavrik, Olga I.   +4 more
openaire   +2 more sources

Methylation status of Dnmt1 promoter depends on poly(ADP-ribosy)lation [PDF]

, 2007
Research is focused on CpG islands and on the mechanism that poly(ADP-ribosyl)ation uses to defend the unmethylated state of these important DNA sequences which are located in the promoter regions of the housekeeping genes having a role of transcription ...
Zampieri, Michele
core   +1 more source

Sp1 Targeted PARP1 Inhibition Protects Cardiomyocytes From Myocardial Ischemia–Reperfusion Injury via Downregulation of Autophagy

Frontiers in Cell and Developmental Biology, 2021
Myocardial ischemia–reperfusion injury (MIRI), characterized by post-ischemic cardiomyocytes death and reperfusion myocardial damage, is a lethal yet unresolved complication in the treatment of acute myocardial infarction (AMI).
Yifeng Xu, Boqian Wang, Xiaoxiao Liu, Yunfei Deng, Yanqi Zhu, Feng Zhu, Yanyan Liang, Hongli Li   +7 more
doaj   +1 more source

Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling

Molecules and Cells, 2023
Summary PARP1, an established anti-cancer target that regulates many cellular pathways, including DNA repair signaling, has been intensely studied for decades as a poly(ADP-ribosyl)transferase. Although recent studies have revealed the prevalence of mono-
E. Longarini, Helen Dauben, C. Locatelli, Anne R. Wondisford, Rebecca Smith, Charlotte Muench, Andreas Kolvenbach, M. L. Lynskey, A. Pope, J. Bonfiglio, Eva Pinto Jurado, R. Fajka‐Boja, T. Colby, M. Schuller, I. Ahel, Gyula Timinszky, Roderick J. O’Sullivan, S. Huet, I. Matic   +18 more
semanticscholar   +1 more source

PARP1-Erk synergism in proliferating cells [PDF]

Oncotarget, 2018
A synergism between PARP1 and phosphorylated Erk mediating IEG (immediate early gene) expression has been recently reported in cerebral neurons and cardiomyocytes. Stimulation induced PARP-Erk synergism was required for IEG expression underlying synaptic plasticity and long-term memory acquisition during learning.
Visochek, Leonid, Cohen-Armon, Malka
openaire   +2 more sources

PARP1 roles in DNA repair and DNA replication: The basi(c)s of PARP inhibitor efficacy and resistance.

Seminars in Oncology, 2023
Genome integrity is the subject of constant insult from endogenous and exogenous sources. In order to cope, eukaryotic cells have evolved an elaborate network of DNA repair factors that accommodate diverse lesion types and exhibit considerable functional
Petar-Bogomil Kanev, Aleksandar Atemin, S. Stoynov, Radoslav Aleksandrov   +3 more
semanticscholar   +1 more source

PARP1 promotes the progression of hepatocellular carcinoma by regulating expression of POU2F2 [PDF]

Zhongguo aizheng zazhi
Background and purpose: Hepatocellular carcinoma (HCC) is a major disease seriously threatening human health. Poly (ADP-ribose) polymerase-1 (PARP1) is an enzyme that catalyzes poly ADP-ribosylation.
WEN Ziqiang, LAN Junliang, ZHOU Bo, XU Qiwei
doaj   +3 more sources