Results 61 to 70 of about 39,225 (199)

Noncoding RNAs link PARP1 to heterochromatin [PDF]

Cell Cycle, 2012
Comment on: Guetg C et al. Mol Cell 2012; 45:790-800.
Guetg Claudio, Santoro Raffaella
openaire   +4 more sources

TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response

Cell Reports, 2015
PARP1 is the main sensor of single- and double-strand breaks in DNA and, in building chains of poly(ADP-ribose), promotes the recruitment of many downstream signaling and effector proteins involved in the DNA damage response (DDR).
Lauren M. Young, Antonio Marzio, Pablo Perez-Duran, Dylan A. Reid, Daniel N. Meredith, Domenico Roberti, Ayelet Star, Eli Rothenberg, Beatrix Ueberheide, Michele Pagano   +9 more
doaj   +1 more source

PARP1′s Involvement in RNA Polymerase II Elongation: Pausing and Releasing Regulation through the Integrator and Super Elongation Complex

Cells, 2022
RNA polymerase elongation along the gene body is tightly regulated to ensure proper transcription and alternative splicing events. Understanding the mechanism and factors critical in regulating the rate of RNA polymerase II elongation and processivity is
Elena A. Matveeva, Hejer Dhahri, Yvonne Fondufe-Mittendorf   +2 more
doaj   +1 more source

Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. [PDF]

PLoS Pathogens, 2018
Latent membrane protein 1 (LMP1) is the major transforming protein of Epstein-Barr virus (EBV) and is critical for EBV-induced B-cell transformation in vitro. Poly(ADP-ribose) polymerase 1 (PARP1) regulates accessibility of chromatin, alters functions of
Michael Hulse, Lisa B Caruso, Jozef Madzo, Yinfei Tan, Sarah Johnson, Italo Tempera   +5 more
doaj   +1 more source

TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma

Oncogene
Hepatocellular carcinoma (HCC) stands as the fifth most prevalent malignant tumor on a global scale and presents as the second leading cause of cancer-related mortality.
Longpo Geng, Mingming Zhu, Dongjun Luo, Huihui Chen, Binghua Li, Yuanxiang Lao, Hongda An, Yue Wu, Yunzheng Li, Anliang Xia, Yi Shi, Zhuting Tong, Shanshan Lu, Dengqiu Xu, Xu Wang, Wenjun Zhang, Beicheng Sun, Zhu Xu   +17 more
semanticscholar   +1 more source

Multifaceted Role of PARP1 in Maintaining Genome Stability Through Its Binding to Alternative DNA Structures

Journal of Molecular Biology, 2023
Alternative DNA structures that differ from the canonical B-form of DNA can arise from repetitive sequences and play beneficial roles in many cellular processes such as gene regulation and chromatin organization.
Natalie Laspata, D. Muoio, Elise Fouquerel   +2 more
semanticscholar   +1 more source

The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2

Вавиловский журнал генетики и селекции
Oncological diseases remain a leading cause of pathological mortality worldwide, making the development of anticancer drugs a critical focus in medicinal chemistry.
N. S. Dyrkheeva, I. A. Chernyshova, A. F. Arutyunyan, A. L. Zakharenko, M. M. Kutuzov, K. N. Naumenko, A. S. Venzel, V. A. Ivanisenko, S. M. Deyev, A. L. Zhuze, O. I. Lavrik   +10 more
doaj   +1 more source

A review of poly(ADP-ribose)polymerase-1 (PARP1) role and its inhibitors bearing pyrazole or indazole core for cancer therapy.

Biochemical Pharmacology
Cancer is a disease with a high mortality rate characterized by uncontrolled proliferation of abnormal cells. The hallmarks of cancer evidence the acquired cells characteristics that promote the growth of malignant tumours, including genomic instability ...
Inês M Bastos, Sandra Rebelo, Vera L. M. Silva   +2 more
semanticscholar   +1 more source

Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing

Epigenetics & Chromatin, 2019
Background Recently, we showed that PARP1 is involved in cotranscriptional splicing, possibly by bridging chromatin to RNA and recruiting splicing factors.
Elena A. Matveeva, Qamar M. H. Al-Tinawi, Eric C. Rouchka, Yvonne N. Fondufe-Mittendorf   +3 more
doaj   +1 more source

The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation

Nucleic Acids Research
TIMELESS (TIM) in the fork protection complex acts as a scaffold of the replisome to prevent its uncoupling and ensure efficient DNA replication fork progression. Nevertheless, its underlying basis for coordinating leading and lagging strand synthesis to
Joanne Saldanha, Julie Rageul, Jinal A. Patel, Amy L. Phi, Natalie Lo, Jennifer J. Park, Hyungjin Kim   +6 more
semanticscholar   +1 more source