Results 51 to 60 of about 55,025 (289)
PARP1: Liaison of Chromatin Remodeling and Transcription
Cancers, 2022 Poly(ADP-ribosyl)ation (PARylation) is a covalent post-translational modification and plays a key role in the immediate response of cells to stress signals. Poly(ADP-ribose) polymerase 1 (PARP1), the founding member of the PARP superfamily, synthesizes long and branched polymers of ADP-ribose (PAR) onto acceptor proteins, thereby modulating their ...
Wen Zong +4 more
openaire +2 more sources
Single-particle analysis of full-length human poly(ADP-ribose) polymerase 1
Biophysics and Physicobiology, 2019 PolyADP-ribosylation (PARylation) is a posttranslational modification that is involved in the various cellular functions including DNA repair, genomic stability, and transcriptional regulation.
Kenichi Kouyama +5 more
doaj +1 more source
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
eLife, 2020 It is being increasingly appreciated that the immunomodulatory functions of PARP1 inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi possess both PARP1 inhibition and PARP1 trapping activities.
Chiho Kim, Xu-Dong Wang, Yonghao Yu
doaj +1 more source
Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation
Scientific Reports, 2022 Poly(ADP-ribose) polymerase-1 (PARP1), a fundamental DNA repair enzyme, is known to regulate β cell death, replication, and insulin secretion. PARP1 knockout (KO) mice are resistant to diabetes, while PARP1 overactivation contributes to β cell death ...
Nidheesh Dadheech +4 more
doaj +1 more source
Biomedicines, 2022 Oxidative stress contributes to numerous diseases, including cancer. CSB is an ATP-dependent chromatin remodeler critical for oxidative stress relief. PARP1 is the major sensor for DNA breaks and fundamental for efficient single-strand break repair.
Robert J. Lake +2 more
doaj +1 more source
BMN673 sensitizes rhabdomyosarcoma tumors to irradiation in vivo [PDF]
, 2020 Bone and soft tissue sarcomas are mesenchymal tumors that occur rarely in adults, representing only 1% of total malignancies, but comprise up to 13% of malignant tumors in children.1 Rhabdomyosarcoma, a soft tissue sarcoma that commonly affects children,
Jacob, Connor
core
Restoration of Sensitivity in Chemo [PDF]
, 2013 Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Despite multimodal treatments including surgery, chemotherapy and radiotherapy the prognosis remains poor and relapse occurs regularly.
Boxhammer, Veronika +10 more
core +1 more source
PARP1 associates with R-loops to promote their resolution and genome stability
Nucleic Acids Research, 2023 PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate their resolution.
Natalie Laspata +12 more
semanticscholar +1 more source
PARP1 Inhibitors: Antitumor Drug Design [PDF]
Acta Naturae, 2015 The poly (ADP-ribose) polymerase 1 (PARP1) enzyme is one of the promising molecular targets for the discovery of antitumor drugs. PARP1 is a common nuclear protein (1-2 million molecules per cell) serving as a sensor for DNA strand breaks. Increased PARP1 expression is sometimes observed in melanomas, breast cancer, lung cancer, and other neoplastic ...
MALYUCHENKO N.V. +4 more
openaire +3 more sources
Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli. [PDF]
PLoS Genetics, 2012 Poly(ADP-ribose) polymerase 1 (PARP1), a nuclear protein, utilizes NAD to synthesize poly(AD-Pribose) (pADPr), resulting in both automodification and the modification of acceptor proteins.
Ernest K Boamah +4 more
doaj +1 more source