Results 51 to 60 of about 39,225 (199)

Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG

Nature Communications
Ester-linked post-translational modifications, including serine and threonine ubiquitination, have gained recognition as important cellular signals. However, their detection remains a significant challenge due to the chemical lability of the ester bond ...
E. Longarini, Ivan Matić
semanticscholar   +1 more source

PARP1 roles in DNA repair and DNA replication: The basi(c)s of PARP inhibitor efficacy and resistance.

Seminars in Oncology, 2023
Genome integrity is the subject of constant insult from endogenous and exogenous sources. In order to cope, eukaryotic cells have evolved an elaborate network of DNA repair factors that accommodate diverse lesion types and exhibit considerable functional
Petar-Bogomil Kanev, Aleksandar Atemin, S. Stoynov, Radoslav Aleksandrov   +3 more
semanticscholar   +1 more source

Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish

Scientific Reports
Defects in DNA single-strand break repair are associated with neurodevelopmental and neurodegenerative disorders. One such disorder is that resulting from mutations in XRCC1, a scaffold protein that plays a central role in DNA single-strand base repair ...
Svetlana A. Semenova, Deepthi Nammi, Grace B. Garrett, Gennady Margolin, Jennifer L. Sinclair, Reza Maroofian, Keith W. Caldecott, Harold A. Burgess   +7 more
doaj   +1 more source

PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma—A Clinical and an In Vitro Study

Cells, 2021
(1) Background: Poly(ADP-ribose) polymerase 1) (PARP1) is a pleiotropic enzyme involved in several cellular processes, e.g., DNA damage repair, regulation of mitosis, and immune response.
Piotr Kupczyk, Aleksandra Simiczyjew, Jakub Marczuk, Ewelina Dratkiewicz, Artur Beberok, Jakub Rok, Malgorzata Pieniazek, Przemyslaw Biecek, Dmitry Nevozhay, Bartosz Slowikowski, Grzegorz Chodaczek, Dorota Wrzesniok, Dorota Nowak, Piotr Donizy   +13 more
doaj   +1 more source

PARP1 UFMylation ensures the stability of stalled replication forks

Proceedings of the National Academy of Sciences of the United States of America
Significance UFMylation, the latest addition to the ubiquitin-like posttranslational modifications, plays an important role in a variety of cellular activities.
Y. Gong, Zhifeng Wang, Wen Zong, Ruifeng Shi, Wenli Sun, Sijia Wang, Bin Peng, Shunichi Takeda, Zhao-Qi Wang, Xingzhi Xu   +9 more
semanticscholar   +1 more source

Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper

Clinical Cancer Research, 2022
Purpose: We hypothesized that inhibition and trapping of PARP1 alone would be sufficient to achieve antitumor activity. In particular, we aimed to achieve selectivity over PARP2, which has been shown to play a role in the survival of hematopoietic/stem ...
G. Illuzzi, A. Staniszewska, Sonja J. Gill, A. Pike, Lisa McWilliams, S. Critchlow, Anna Cronin, S. Fawell, Glen Hawthorne, K. Jamal, J. Johannes, Emilyanne Leonard, Ruth Macdonald, G. Maglennon, Jenni Nikkil, M. O’Connor, Aaron Smith, Harriet Southgate, Joanne Wilson, James Yates, S. Cosulich, Elisabetta Leo   +21 more
semanticscholar   +1 more source

Visualization of a DNA-PK/PARP1 complex [PDF]

Nucleic Acids Research, 2012
The DNA-dependent protein kinase (DNA-PK) and Poly(ADP-ribose) polymerase-1 (PARP1) are critical enzymes that reduce genomic damage caused by DNA lesions. They are both activated by DNA strand breaks generated by physiological and environmental factors, and they have been shown to interact.
Spagnolo L, Barbeau J, Curtin NJ, Morris EP, Pearl LH   +4 more
openaire   +4 more sources

Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer

Science Advances, 2023
Recent studies have pointed to PARP1 trapping as a key determinant of the anticancer effects of PARP1 inhibitors (PARPi). We identified RNF114, as a PARylation-dependent, E3 ubiquitin ligase involved in DNA damage response.
Peng Li, Yuanli Zhen, Chiho Kim, Zhengshuai Liu, Jianwei Hao, Heping Deng, Hejun Deng, Min Zhou, Xu-dong Wang, Tian Qin, Yonghao Yu   +10 more
semanticscholar   +1 more source

NEAT1 Knockdown Suppresses the Cisplatin Resistance in Ovarian Cancer by Regulating miR-770-5p/PARP1 Axis

Cancer Management and Research, 2020
Mingzhe Zhu,1,* Lei Yang,2,* Xin Wang3 1Department of Obstetrics and Gynecology, Jilin Medical College Affiliated Hospital, Jilin City, Jilin Province 132011, People’s Republic of China; 2Department of Medical Clinic, Yuhuangding Hospital, Yantai ...
Zhu M, Yang L, Wang X
doaj  

PARP1 inhibition protects mice against Japanese encephalitis virus infection

Cell Reports, 2023
Summary: Japanese encephalitis (JE) is a vector-borne viral disease that causes acute encephalitis in children. Although vaccines have been developed against the JE virus (JEV), no effective antiviral therapy exists.
Perumal Arumugam Desingu, Sneha Mishra, Lavanya Dindi, Shalini Srinivasan, Raju S. Rajmani, Venkatraman Ravi, Ankit Kumar Tamta, Sukanya Raghu, Krishnega Murugasamy, Anwit Shriniwas Pandit, Nagalingam R. Sundaresan   +10 more
doaj   +1 more source