Results 51 to 60 of about 6,651 (207)
Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
Cell Stress, 2023 The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease.
Maria Castedo +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Cancer Management and Research, 2023 Bustanur Rosidi,1 Diana Priyatno,1 Teguh Pribadi Putra,1 Irawan Yusuf1,2 1Division of Proteomics, Mochtar Riady Institute for Nanotechnology and Medical Science Group, University of Pelita Harapan, Tangerang, Banten, Indonesia; 2Faculty of Medicine ...
Rosidi B, Priyatno D, Putra TP, Yusuf I
doaj
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish
Scientific ReportsDefects in DNA single-strand break repair are associated with neurodevelopmental and neurodegenerative disorders. One such disorder is that resulting from mutations in XRCC1, a scaffold protein that plays a central role in DNA single-strand base repair ...
Svetlana A. Semenova +7 more
doaj +1 more source
Analisi in silico della doxiciclina come inibitore della PARP1 nella terapia dell'Alzheimer
, 2023 LAUREA MAGISTRALELa PARP1 (Poly-ADP ribose polymerase-1) è un enzima coinvolto nella riparazione del DNA danneggiato e nei processi infiammatori. Studi recenti hanno suggerito che l'attivazione eccessiva della PARP1 nel cervello degli individui affetti ...
STRATI, SARA
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
PARP1 inhibition protects mice against Japanese encephalitis virus infection
Cell Reports, 2023 Summary: Japanese encephalitis (JE) is a vector-borne viral disease that causes acute encephalitis in children. Although vaccines have been developed against the JE virus (JEV), no effective antiviral therapy exists.
Perumal Arumugam Desingu +10 more
doaj +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. [PDF]
PLoS Pathogens, 2018 Latent membrane protein 1 (LMP1) is the major transforming protein of Epstein-Barr virus (EBV) and is critical for EBV-induced B-cell transformation in vitro. Poly(ADP-ribose) polymerase 1 (PARP1) regulates accessibility of chromatin, alters functions of
Michael Hulse +5 more
doaj +1 more source