Results 71 to 80 of about 39,225 (199)

Involvement of PARP1 in the regulation of alternative splicing [PDF]

Cell Discovery, 2016
AbstractSpecialized chromatin structures such as nucleosomes with specific histone modifications decorate exons in eukaryotic genomes, suggesting a functional connection between chromatin organization and the regulation of pre-mRNA splicing. Through profiling the functional location of Poly (ADP) ribose polymerase, we observed that it is associated ...
Elena Matveeva, John Maiorano, Qingyang Zhang, Abdallah M Eteleeb, Paolo Convertini, Jing Chen, Vittoria Infantino, Stefan Stamm, Jiping Wang, Eric C Rouchka, Yvonne N Fondufe-Mittendorf   +10 more
openaire   +3 more sources

PARP1-dependent DNA-protein crosslink repair

Nature Communications
DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are also involved remains
Zita Fábián, Ellen S. Kakulidis, I. Hendriks, Ulrike Kühbacher, N. B. Larsen, Marta Oliva-Santiago, Junhui Wang, Xueyuan Leng, Barbara Dirac-Svejstrup, J. Svejstrup, M. L. Nielsen, K. Caldecott, Julien P. Duxin   +12 more
semanticscholar   +1 more source

Differential trapping of PARP1 and PARP2 by clinical PARP inhibitors

Cancer Research, 2012
Small molecule inhibitors of polyADP-ribose polymerase (PARP) are thought to mediate their antitumor effects as catalytic inhibitors that block repair of DNA single strand breaks.
J. Murai, Shar-yin N. Huang, B. Das, Amélie Renaud, Yiping Zhang, J. Doroshow, J. Ji, S. Takeda, Y. Pommier   +8 more
semanticscholar   +1 more source

Poly(ADP-ribose) polymerase 1 searches DNA via a ‘monkey bar’ mechanism

eLife, 2018
Poly(ADP-ribose) polymerase 1 (PARP1) is both a first responder to DNA damage and a chromatin architectural protein. How PARP1 rapidly finds DNA damage sites in the context of a nucleus filled with undamaged DNA, to which it also binds, is an unresolved ...
Johannes Rudolph, Jyothi Mahadevan, Pamela Dyer, Karolin Luger   +3 more
doaj   +1 more source

Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair

Redox Biology, 2018
Hallmarks of cancer cells include uncontrolled growth and rapid proliferation; thus, cyclin-dependent kinases are a therapeutic target for cancer treatment.
Dominika Tempka, Paulina Tokarz, Kinga Chmielewska, Magdalena Kluska, Julita Pietrzak, Żaneta Rygielska, László Virág, Agnieszka Robaszkiewicz   +7 more
doaj   +1 more source

Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. [PDF]

PLoS ONE, 2016
Hyperglycemia and hypertension impair endothelial function in part through oxidative stress-activated poly (ADP-ribose) polymerase 1 (PARP1). Biguanides and angiotensin II receptor blockers (ARBs) such as metformin and telmisartan have a vascular ...
Fenqing Shang, Jiao Zhang, Zhao Li, Jin Zhang, Yanjun Yin, Yaqiong Wang, Traci L Marin, Brendan Gongol, Han Xiao, You-Yi Zhang, Zhen Chen, John Y-J Shyy, Ting Lei   +12 more
doaj   +1 more source

USP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity

Science Advances
PARP inhibitors (PARPi) represent a game-changing treatment for patients with ovarian cancer with tumors deficient for the homologous recombination (HR) pathway treated with platinum (Pt)–based therapy. PARPi exert their cytotoxic effect by both trapping
Anna Nespolo, Linda Stefenatti, Ilenia Pellarin, A. Gambelli, G. L. Rampioni Vinciguerra, Javad Karimbayli, Sara Barozzi, Fabrizio Orsenigo, Riccardo Spizzo, Milena S. Nicoloso, I. Segatto, Sara D'Andrea, M. Bartoletti, E. Lucia, Giorgio Giorda, Vincenzo Canzonieri, F. Puglisi, B. Belletti, M. Schiappacassi, Gustavo Baldassarre, M. Sonego   +20 more
semanticscholar   +1 more source

The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2014
Poly(ADP-ribose) polymerase-1 (PARP1) catalyzes the poly(ADP-ribosyl)ation of protein acceptors using NAD+ as the substrate is now considered as an important target for development of anticancer therapy. PARP1 is known to be post-translationally modified
Lianhua Piao, Daechun Kang, Takehiro Suzuki, Akiko Masuda, Naoshi Dohmae, Yusuke Nakamura, Ryuji Hamamoto   +6 more
doaj   +1 more source

Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks

Nature Communications
Poly(ADP-ribose) polymerase 1 (PARP1) detects DNA strand breaks that occur in duplex DNA and chromatin. Here, correlative optical tweezers and fluorescence microscopy reveal how single molecules of PARP1 identify single-strand breaks (i.e., nicks ...
Matthew A. Schaich, Tyler M. Weaver, Jennifer A. Rakowski, Vera Roginskaya, Liam P. Leary, Aafke A. Van den Berg, Janet H. Iwasa, Bret D. Freudenthal, Bennett Van Houten   +8 more
doaj   +1 more source

Atractylenolide I ameliorates sepsis-induced cardiomyocyte injury by inhibiting macrophage polarization through the modulation of the PARP1/NLRP3 signaling pathway.

Tissue & Cell
Sepsis-induced cardiomyopathy (SIC) leads to high mortality and has no effective treatment strategy. Atractylenolide Ⅰ (AT-I) is a sesquiterpene lactone compound and possesses various biological activities such as anti-inflammatory and organ protection ...
Dan Wang, Zhiqiang Lin, Yiqing Zhou, Meixia Su, Haiwang Zhang, Lixia Yu, Minghui Li   +6 more
semanticscholar   +1 more source