Results 71 to 80 of about 55,025 (289)

Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

Cell Stress, 2023
The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease.
Maria Castedo, Antoine Lafarge, Guido Kroemer   +2 more
doaj   +1 more source

The PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models

Genome Medicine
Poly (ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitors (PARPi) are targeted therapies approved for homologous recombination repair (HRR)-deficient breast, ovarian, pancreatic, and prostate cancers.
A. Herencia-Ropero, A. Llop-Guevara, A. Staniszewska, Joanna Domènech-Vivó, Eduardo García-Galea, A. Moles‐Fernández, F. Pedretti, Heura Domenech, O. Rodríguez, M. Guzman, E. Arenas, H. Verdaguer, F. Calero-Nieto, S. Talbot, L. Tobalina, Elisabetta Leo, Alan Lau, P. Nuciforo, R. Dienstmann, T. Macarulla, Joaquin Arribas, O. Díez, S. Gutiérrez‐Enríquez, J. Forment, M. O’Connor, M. Albertella, J. Balmaña, V. Serra   +27 more
semanticscholar   +1 more source

NEAT1 Knockdown Suppresses the Cisplatin Resistance in Ovarian Cancer by Regulating miR-770-5p/PARP1 Axis

Cancer Management and Research, 2020
Mingzhe Zhu,1,* Lei Yang,2,* Xin Wang3 1Department of Obstetrics and Gynecology, Jilin Medical College Affiliated Hospital, Jilin City, Jilin Province 132011, People’s Republic of China; 2Department of Medical Clinic, Yuhuangding Hospital, Yantai ...
Zhu M, Yang L, Wang X
doaj  

Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG

Nature Communications
Ester-linked post-translational modifications, including serine and threonine ubiquitination, have gained recognition as important cellular signals. However, their detection remains a significant challenge due to the chemical lability of the ester bond ...
E. Longarini, Ivan Matić
semanticscholar   +1 more source

Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper

Clinical Cancer Research, 2022
Purpose: We hypothesized that inhibition and trapping of PARP1 alone would be sufficient to achieve antitumor activity. In particular, we aimed to achieve selectivity over PARP2, which has been shown to play a role in the survival of hematopoietic/stem ...
G. Illuzzi, A. Staniszewska, Sonja J. Gill, A. Pike, Lisa McWilliams, S. Critchlow, Anna Cronin, S. Fawell, Glen Hawthorne, K. Jamal, J. Johannes, Emilyanne Leonard, Ruth Macdonald, G. Maglennon, Jenni Nikkil, M. O’Connor, Aaron Smith, Harriet Southgate, Joanne Wilson, James Yates, S. Cosulich, Elisabetta Leo   +21 more
semanticscholar   +1 more source

Radioiodinated PARP1 tracers for glioblastoma imaging [PDF]

EJNMMI Research, 2015
Although the understanding of the genetic and molecular basis of cancer has advanced significantly over the past several decades, imaging and treatment options for glioblastoma patients have been more limited (N Engl J Med 359:492-507, 2008). This is in part due to difficulties in diagnosing this disease early, combined with its diffuse, infiltrative ...
Salinas, Beatriz, Irwin, Christopher P., Kossatz, Susanne, Bolaender, Alexander, Chiosis, Gabriela, Pillarsetty, Nagavarakishore, Weber, Wolfgang A., Reiner, Thomas   +7 more
openaire   +2 more sources

A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation. [PDF]

, 2019
Nicotinamide adenine dinucleotide (NAD+)-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification in particular for protein poly-ADP ...
Chen, Jingwen, Cheng, Qinqin, Dai, Zhefu, Evdokimov, Nikolai M, Lam, Albert T, Louie, Stan G, Lu, Yanran, Pei, Hua, Zhang, Xiao-Nan, Zhang, Yong   +9 more
core   +1 more source

PARP-1 regulates DNA repair factor availability. [PDF]

, 2018
PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP-1 enzymatic
Birbe, Ruth, Brand, Lucas J, Cendon-Florez, Ylenia, Chand, Saswati N., de Leeuw, Renée, Dicker, Adam, MD, PhD, Dylgjeri, Emanuela, Evans, Joseph, Feng, Felix Y, Gallagher, Peter, Gaur, Sanchaika, Gomella, Leonard G, Gordon, Nicolas, Han, Sumin, Huang, Fangjin, Kelly, William Kevin, Knudsen, Beatrice, Knudsen, Karen E, Lallas, Costas D, Leiby, Benjamin E, Mandigo, Amy C., McCann, Jennifer J, McCue, Peter, McNair, Christopher, Parsons, Theodore, Poudel Neupane, Neermala, Raj, Ganesh V, Schiewer, M J, Shafi, Ayesha A, Trabulsi, Edouard J, Visakorpi, Tapio, Zhao, Shuang G   +31 more
core   +2 more sources

PARP1 UFMylation ensures the stability of stalled replication forks

Proceedings of the National Academy of Sciences of the United States of America
Significance UFMylation, the latest addition to the ubiquitin-like posttranslational modifications, plays an important role in a variety of cellular activities.
Y. Gong, Zhifeng Wang, Wen Zong, Ruifeng Shi, Wenli Sun, Sijia Wang, Bin Peng, Shunichi Takeda, Zhao-Qi Wang, Xingzhi Xu   +9 more
semanticscholar   +1 more source

Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer

Science Advances, 2023
Recent studies have pointed to PARP1 trapping as a key determinant of the anticancer effects of PARP1 inhibitors (PARPi). We identified RNF114, as a PARylation-dependent, E3 ubiquitin ligase involved in DNA damage response.
Peng Li, Yuanli Zhen, Chiho Kim, Zhengshuai Liu, Jianwei Hao, Heping Deng, Hejun Deng, Min Zhou, Xu-dong Wang, Tian Qin, Yonghao Yu   +10 more
semanticscholar   +1 more source