Results 91 to 100 of about 39,225 (199)

Respiratory Virus-Induced PARP1 Alters DC Metabolism and Antiviral Immunity Inducing Pulmonary Immunopathology

Viruses
Previous studies from our laboratory and others have established the dendritic cell (DC) as a key target of RSV that drives infection-induced pathology. Analysis of RSV-induced transcriptomic changes in RSV-infected DC revealed metabolic gene signatures ...
Mohamed M. Mire, Srikanth Elesela, Susan Morris, Gabriel Corfas, Andrew Rasky, Nicholas W. Lukacs   +5 more
doaj   +1 more source

Resveratrol Inhibits Nucleosome Binding and Catalytic Activity of PARP1

Biomolecules
The natural polyphenol resveratrol is a biologically active compound that interacts with DNA and affects the activity of some nuclear enzymes. Its effect on the interaction between nucleosomes and poly(ADP-ribose) polymerase-1 (PARP1) and on the ...
Daria O. Koshkina, Natalya V. Maluchenko, Anna N. Korovina, Angelina A. Lobanova, Alexey V. Feofanov, Vasily M. Studitsky   +5 more
doaj   +1 more source

PARP1 Gene [PDF]

, 2020
openaire   +1 more source

PARP1 as a novel therapeutic and diagnostic tool in autoimmune rheumatic diseases: a systematic literature review. [PDF]

Rheumatol Int
Dey M, Dey M.
europepmc   +1 more source

Cooperative molecular interaction networks govern PARP1 inhibitor selectivity and binding affinity. [PDF]

PLoS Comput Biol
Feito A, DeMoya-Valenzuela N, Privat C, R Tejedor A, Paniagua-Herranz L, Garaizar A, Ocana A, Espinosa JR.   +7 more
europepmc   +1 more source

PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer's disease model. [PDF]

Proc Natl Acad Sci U S A
Jhaldiyal A, Kumari M, Guttman LC, Tripathi T, Khan MR, Wang J, Biswas D, Pasupuleti A, Aggarwal A, Pandya S, Chou SC, Panicker N, Monghekar A, Albert M, Bekris LM, Leverenz JB, Kam TI, Dawson TM, Dawson VL.   +18 more
europepmc   +1 more source

Structural Determinants of PARP1 Selectivity from Molecular Dynamics Analysis of PARP1 and PARP2 Complexes. [PDF]

Molecules
Shkil DO, Chesnokova NA, Ivashchenko AA, Petersen EV, Maximov PY.   +4 more
europepmc   +1 more source

The first and second zinc finger domains from Poly-ADP-ribose polymerase 1 (PARP1) are modified by hydrogen sulfide. [PDF]

J Biol Inorg Chem
Williams AJ, Michel SLJ.
europepmc   +1 more source

Comprehensive metabolomic profiling of Egyptian Salvia species reveals promising leads for chemopreventive and anti-inflammatory drug development: In vitro and In silico study. [PDF]

Sci Rep
Hamed AR, Ali SK, Abdel-Halim SA, Bata SM, Hegazi NM, Mohamed TA, Hegazy MF.   +6 more
europepmc   +1 more source

Nicotinamide Ameliorates Deoxynivalenol-Induced Injury in Renal Cells via Inhibiting PARP1 Hyperactivation and Restoring NAD⁺ Homeostasis. [PDF]

Toxins (Basel)
Chen C, Qin Y, Luo Z, Mu P, Wen J, Deng Y.   +5 more
europepmc   +1 more source