Results 111 to 120 of about 55,025 (289)
PARP1-dependent DNA-protein crosslink repair
Nature CommunicationsDNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are also involved remains
Zita Fábián +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth +10 more
wiley +1 more source
Poly(ADP-ribose) polymerase 1 searches DNA via a ‘monkey bar’ mechanism
eLife, 2018 Poly(ADP-ribose) polymerase 1 (PARP1) is both a first responder to DNA damage and a chromatin architectural protein. How PARP1 rapidly finds DNA damage sites in the context of a nucleus filled with undamaged DNA, to which it also binds, is an unresolved ...
Johannes Rudolph +3 more
doaj +1 more source
Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo [PDF]
, 2016 Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of ...
Berek, Jonathan S +5 more
core +2 more sources
The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation
Nucleic Acids ResearchTIMELESS (TIM) in the fork protection complex acts as a scaffold of the replisome to prevent its uncoupling and ensure efficient DNA replication fork progression. Nevertheless, its underlying basis for coordinating leading and lagging strand synthesis to
Joanne Saldanha +6 more
semanticscholar +1 more source
A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance
Advanced Science, EarlyView.A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang +9 more
wiley +1 more source
Вавиловский журнал генетики и селекцииOncological diseases remain a leading cause of pathological mortality worldwide, making the development of anticancer drugs a critical focus in medicinal chemistry.
N. S. Dyrkheeva +10 more
doaj +1 more source
Epigenetics & Chromatin, 2019 Background Recently, we showed that PARP1 is involved in cotranscriptional splicing, possibly by bridging chromatin to RNA and recruiting splicing factors.
Elena A. Matveeva +3 more
doaj +1 more source
Long noncoding RNAs in prostate cancer: overview and clinical implications. [PDF]
, 2016 Prostate cancer is the second most common cause of cancer mortality among men in the United States. While many prostate cancers are indolent, an important subset of patients experiences disease recurrence after conventional therapy and progresses to ...
Feng, Felix Y, Malik, Bhavna
core +3 more sources
Nicotinamide Reverses the Warburg Effect in CHO Cell Culture
Biotechnology and Bioengineering, EarlyView.Abstract The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey +7 more
wiley +1 more source