Results 111 to 120 of about 32,646 (215)

Mitochondrial Mediated Apoptosis Evaluation of Myristicin on Triple Negative Breast Cancer Model Via Bcl2/Bid Pathway

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Among 15‐20 cases of breast cancer, triple‐negative breast cancer (TNBC) is the deadliest form of the disease. The most effective form of treatment for this type of cancer is still targeted chemotherapy because it lacks hormone receptors. Myristicin, an active aromatic compound with anticancer properties, is mostly found in nutmeg.
Sudhina Sufina Nazar, Aswathy Vadakkumkattle Ajaykumar, Janeesh Plakkal Ayyappan   +2 more
wiley   +1 more source

CLRN1 Variants in Müller Cells Cause Mitochondrial Dysfunction in USH3A Retinal Organoids

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
We generated retinal organoids from a patient with USH3A and performed single‐cell RNA sequencing. CLRN1 was specifically expressed in Müller cells, where its variants led to mitochondrial dysfunction and photoreceptor degeneration. ABSTRACT Background Usher syndrome 3A (USH3A), caused by mutations in the CLRN1 gene, leads to retinitis pigmentosa and ...
Rui Zhang, Xinbo Ji, Han Yu, Jingwen Xu, Yu Wang, Ping Sun, Yingxin Wang, Yao Tang, Zexin Zhan, Yichang Jiao, Didi Shan, Pengfei Lin, Dong‐dong Wang, Yuying Zhao, Xianyang Liu, Chuanzhu Yan, Jianqiao Li, Mingfeng Li, Fuchen Liu, Shengping Hou   +19 more
wiley   +1 more source

Network Pharmacology Combined With Metabonomics and Transcriptomics Reveals the Mechanism of Rubus Chingii Hu in Alleviating Nephrotoxicity Caused by Tripterygium Glycosides Tablet

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Flow chart of RCH to improve TGT‐induced nephrotoxicity. ABSTRACT Researches on Tripterygium glycosides tablets (TGT) often overlook renal toxicity from prolonged use. Rubus chingii Hu (RCH) is beneficial to kidney health and has an unclear role in reducing nephrotoxicity.
Cong Zhang, Zepeng Zhang, Tong Zhou, Lei Zhang   +3 more
wiley   +1 more source

USP1 Promotes Malignant Progression of Cervical Cancer Cells by Deubiquitinating and Stabilizing ATG13 to Enhance Autophagic Activity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
USP1, overexpressed in cervical cancer and linked to advanced pathological grade, promotes cervical cancer progression by deubiquitinating and stabilizing ATG13 to enhance autophagy, and USP1 inhibitor ML323 can reverse this oncogenic effect, making USP1 a promising therapeutic target for cervical cancer.
Chunyan Liu, Zhitong Liu, Changyan Dong, Xiaona Jiang, Xiao Chen   +4 more
wiley   +1 more source

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 8, August 2026.
ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo, Chin‐Chen Pan, Yi‐Wen Liu, Nan‐Haw Chow, Hong‐Lin Cheng, Shan‐Ying Wu, Sheng‐Hui Lan, Chih‐Peng Chang, Hsiao‐Sheng Liu   +8 more
wiley   +1 more source

Early‐Onset Prostate Cancer: Epidemiology, Risk Factors, Biology, Clinical Features, Management, and Early Detection

MedComm, Volume 7, Issue 8, August 2026.
EOPC is a distinct clinicopathological entity separable from SOPC, differing fundamentally in genetic susceptibility, TMPRSS2:ERG fusion frequency, and survival outcomes. Although research remains nascent, this review provides the first comprehensive synthesis of current evidence, offering a critical foundation to guide future investigations into this ...
Xingyu Xiong, Weizhen Zhu, Weichao Huang, Shiyu Zhang, Qi Deng, Jie Yang, Hang Xu, Qiang Wei, Lu Yang   +8 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

PARP1 Gene [PDF]

, 2020
openaire   +1 more source

Exploring the BICC1 Interactome in HEK293T Cells: Insights Into RNA‐Mediated Protein Networks and Biomolecular Condensates

FASEB BioAdvances, Volume 8, Issue 8, August 2026.
Workflow for BICC1 interactome characterization in HEK293T cells. Cells expressing FLAG‐tagged BICC1 (full‐length or ΔSAM) were subjected to co‐immunoprecipitation under RNA‐preserved (−) or RNase‐treated (+) conditions (1). Interacting proteins were identified by LC–MS/MS (2) and analyzed through protein–protein interaction networks and functional ...
Heloísa Monteiro do Amaral‐Prado, Gabriela Alves Moreira, Cristiane Santos, Fernando Henrique Bosso, Felipe Eduardo Ciamponi, Guilherme Oliveira Barbosa, Mario Henrique Bengtson, Katlin Brauer Massirer   +7 more
wiley   +1 more source