Cooperative nucleic acid binding by Poly ADP-ribose polymerase 1 [PDF]
Scientific ReportsPoly (ADP)-ribose polymerase 1 (PARP1) is an abundant nuclear protein well-known for its role in DNA repair yet also participates in DNA replication, transcription, and co-transcriptional splicing, where DNA is undamaged.
Manana Melikishvili +2 more
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Streptavidin-Conjugated DNA for the Boronate Affinity-Based Detection of Poly(ADP-Ribose) Polymerase-1 with Improved Sensitivity [PDF]
Biosensors, 2023 This work reports the development of a fluorescence method for the detection of poly(ADP-ribose) polymerase-1 (PARP1), in which a phenylboronic acid-modified fluorescein isothiocyanate dye (FITC-PBA) was used to recognize the formed poly(ADP-ribose) (PAR)
Fengli Gao +4 more
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Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome [PDF]
JACC: Basic to Translational Science, 2018 Summary: Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress.
Sven Y. Surikow, BHlthSc (Hons) +15 more
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Poly(ADP-ribose) Polymerase-1 in the Nervous System
Neurobiology of Disease, 2000 Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme, activated by DNA strand breaks to participate in DNA repair. Overactivation of PARP by cellular insults depletes its substrate NAD+ and then ATP, leading to a major energy deficit and cell death.
Hyo Chol Ha, Solomon H. Snyder
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The Role of Poly(ADP-ribose) Polymerase 1 in Nuclear and Mitochondrial Base Excision Repair [PDF]
Biomolecules, 2023 Poly(ADP-ribose) (PAR) Polymerase 1 (PARP-1), also known as ADP-ribosyl transferase with diphtheria toxin homology 1 (ARTD-1), is a critical player in DNA damage repair, during which it catalyzes the ADP ribosylation of self and target enzymes. While the
Geoffrey K. Herrmann, Y. Whitney Yin
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Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress [PDF]
Redox Biology, 2014 Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family.
Csaba Hegedűs, László Virág
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Virus–Host Interplay Between Poly (ADP-Ribose) Polymerase 1 and Oncogenic Gammaherpesviruses [PDF]
Frontiers in Microbiology, 2022 The gammaherpesviruses, include the Epstein–Barr virus, Kaposi’s sarcoma-associated herpesvirus, and murine gammaherpesvirus 68. They establish latent infection in the B lymphocytes and are associated with various lymphoproliferative diseases and tumors.
Woo-Chang Chung, Moon Jung Song
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Poly(ADP-ribose) Polymerase 1 Mediates Rab5 Inactivation after DNA Damage. [PDF]
Int J Mol Sci, 2022 Parthanatos is programmed cell death mediated by poly(ADP-ribose) polymerase 1 (PARP1) after DNA damage. PARP1 acts by catalyzing the transfer of poly(ADP-ribose) (PAR) polymers to various nuclear proteins. PAR is subsequently cleaved, generating protein-free PAR polymers, which are translocated to the cytoplasm where they associate with cytoplasmic ...
Mashimo M +8 more
europepmc +3 more sources
The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis [PDF]
Mediators of Inflammation, 2015 Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory ...
Samuel García, Carmen Conde
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Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β [PDF]
Journal of Neuroinflammation, 2011 Background Amyloid β (Aβ) accumulates in Alzheimer's disease (AD) brain. Microglial activation also occurs in AD, and this inflammatory response may contribute to disease progression.
Kauppinen Tiina M +9 more
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