The Prognostic Values of PARP-1 Expression in Uveal Melanoma [PDF]
Cells, 2021 Background: Uveal melanoma is the most common primary intraocular malignancy in adults. In advanced cases, the prognosis is very poor. Thus far, no effective methods of pharmacotherapy of this cancer have been found.
Malgorzata Gajdzis +7 more
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PARP-1 deregulation in multiple sclerosis [PDF]
Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019 Background Poly (ADP-ribose) polymerase 1 (PARP-1) plays pivotal roles in immune and inflammatory responses. Accumulating evidence suggests PARP-1 as a promising target for immunomodulation in multiple sclerosis and natalizumab-associated progressive ...
Maria Meira +8 more
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PARP-1 rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations [PDF]
Medeniyet Medical JournalObjective: Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme in DNA repair pathways and has been implicated in cancer susceptibility. The rs1136410 polymorphism in the PARP-1 gene has shown inconsistent associations with gastrointestinal cancer ...
Amirhosein NASERI +11 more
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PARP-1 couples β-catenin/TCF4 signaling to epithelial–mesenchymal transition in endometriosis [PDF]
Scientific ReportsEndometriosis exhibits epithelial–mesenchymal transition (EMT)-aligned traits that promote invasion and lesion persistence. We investigated whether poly(ADP-ribose) polymerase-1 (PARP-1) coordinates β-catenin/TCF4 activity with EMT programs and whether ...
Lu Zhang +6 more
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PARP‐1 regulates DNA repair factor availability
EMBO Molecular Medicine, 2018 PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP‐1 enzymatic
Matthew J Schiewer +31 more
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Mono-methylated histones control PARP-1 in chromatin and transcription [PDF]
eLifePARP-1 is central to transcriptional regulation under both normal and stress conditions, with the governing mechanisms yet to be fully understood. Our biochemical and ChIP-seq-based analyses showed that PARP-1 binds specifically to active histone marks ...
Gbolahan Bamgbose +3 more
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Multi-stage structure-based virtual screening approach combining 3D pharmacophore, docking and molecular dynamic simulation towards the identification of potential selective PARP-1 inhibitors [PDF]
BMC ChemistryPresently, humanity is confronted with a range of diseases that have high death rates, especially those linked to cancerous growths. Several enzymes and proteins have been discovered as highly attractive targets for cancer treatment.
Mahmoud A. El Hassab +3 more
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Comment on “PARP-1 rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations” [PDF]
Medeniyet Medical JournalOnur ALKAN, Ismail NAZLI, Ahmet BASGOZE
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Response to Letter to the Editor Regarding “PARP-1 rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations” [PDF]
Medeniyet Medical JournalAmirhosein NASERI +3 more
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PARP-1 is a transcriptional rheostat of metabolic and bivalent genes during development [PDF]
Life Science AlliancePARP-1 fine-tunes gene expression to control energy balance and development by selectively repressing and activating critical genes for developmental progression. PARP-1 participates in various cellular processes, including gene regulation. In Drosophila
Gbolahan Bamgbose, Alexei Tulin
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