PARP‐1 regulates DNA repair factor availability [PDF]
EMBO Molecular Medicine, 2018 PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP‐1 enzymatic
Matthew J Schiewer +31 more
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PARP-1 modulates amyloid beta peptide-induced neuronal damage. [PDF]
PLoS ONE, 2013 Amyloid beta peptide (Aβ) causes neurodegeneration by several mechanisms including oxidative stress, which is known to induce DNA damage with the consequent activation of poly (ADP-ribose) polymerase (PARP-1).
Sara Martire +14 more
doaj +8 more sources
PARP-1 deregulation in multiple sclerosis [PDF]
Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019 Background Poly (ADP-ribose) polymerase 1 (PARP-1) plays pivotal roles in immune and inflammatory responses. Accumulating evidence suggests PARP-1 as a promising target for immunomodulation in multiple sclerosis and natalizumab-associated progressive ...
Maria Meira +8 more
doaj +3 more sources
PARP-1 rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations [PDF]
Medeniyet Medical JournalObjective: Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme in DNA repair pathways and has been implicated in cancer susceptibility. The rs1136410 polymorphism in the PARP-1 gene has shown inconsistent associations with gastrointestinal cancer ...
Amirhosein NASERI +11 more
doaj +2 more sources
PARP-1 couples β-catenin/TCF4 signaling to epithelial–mesenchymal transition in endometriosis [PDF]
Scientific ReportsEndometriosis exhibits epithelial–mesenchymal transition (EMT)-aligned traits that promote invasion and lesion persistence. We investigated whether poly(ADP-ribose) polymerase-1 (PARP-1) coordinates β-catenin/TCF4 activity with EMT programs and whether ...
Lu Zhang +6 more
doaj +2 more sources
Cooperative targeting of PARP-1 domains to regulate metabolic and developmental genes [PDF]
Frontiers in Endocrinology, 2023 PARP-1, also known as poly(ADP-ribose) polymerase 1, is a multifunctional nuclear enzyme that plays a critical role in transcriptional regulation through its three functional domains: the N-terminal DNA-binding domain (DBD) containing two zinc fingers ...
Gbolahan Bamgbose +2 more
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Loss of
BMC Genomics, 2007 Background Many lines of evidence suggest that poly(ADP-ribose) polymerase-1 (Parp-1) is involved in transcriptional regulation of various genes as a coactivator or a corepressor by modulating chromatin structure. However, the impact of Parp-1-deficiency
Murakami Yasufumi +9 more
doaj +3 more sources
Mono-methylated histones control PARP-1 in chromatin and transcription [PDF]
eLifePARP-1 is central to transcriptional regulation under both normal and stress conditions, with the governing mechanisms yet to be fully understood. Our biochemical and ChIP-seq-based analyses showed that PARP-1 binds specifically to active histone marks ...
Gbolahan Bamgbose +3 more
doaj +2 more sources
Leveraging PARP-1/2 to Target Distant Metastasis. [PDF]
Int J Mol SciPoly (ADP-Ribose) Polymerase (PARP) inhibitors have changed the outcomes and therapeutic strategy for several cancer types. As a targeted therapeutic mainly for patients with BRCA1/2 mutations, PARP inhibitors have commonly been exploited for their capacity to prevent DNA repair.
Frederick MI +4 more
europepmc +3 more sources
Multi-stage structure-based virtual screening approach combining 3D pharmacophore, docking and molecular dynamic simulation towards the identification of potential selective PARP-1 inhibitors [PDF]
BMC ChemistryPresently, humanity is confronted with a range of diseases that have high death rates, especially those linked to cancerous growths. Several enzymes and proteins have been discovered as highly attractive targets for cancer treatment.
Mahmoud A. El Hassab +3 more
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