PARP-1 rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations. [PDF]
Medeni Med JObjective: Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme in DNA repair pathways and has been implicated in cancer susceptibility. The rs1136410 polymorphism in the PARP-1 gene has shown inconsistent associations with gastrointestinal cancer ...
Naseri A +11 more
europepmc +2 more sources
PARP-1 couples β-catenin/TCF4 signaling to epithelial-mesenchymal transition in endometriosis. [PDF]
Sci RepEndometriosis exhibits epithelial–mesenchymal transition (EMT)-aligned traits that promote invasion and lesion persistence. We investigated whether poly(ADP-ribose) polymerase-1 (PARP-1) coordinates β-catenin/TCF4 activity with EMT programs and whether ...
Zhang L +6 more
europepmc +2 more sources
Mono-methylated histones control PARP-1 in chromatin and transcription. [PDF]
ElifePARP-1 is central to transcriptional regulation under both normal and stress conditions, with the governing mechanisms yet to be fully understood. Our biochemical and ChIP-seq-based analyses showed that PARP-1 binds specifically to active histone marks ...
Bamgbose G, Bordet G, Lodhi N, Tulin A.
europepmc +2 more sources
Comment on "<i>PARP-1</i> rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations". [PDF]
Medeni Med JAlkan O, Nazli I, Basgoze A.
europepmc +2 more sources
Response to Letter to the Editor Regarding "<i>PARP-1</i> rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations". [PDF]
Medeni Med JNaseri A +3 more
europepmc +2 more sources
The Prognostic Values of PARP-1 Expression in Uveal Melanoma
Cells, 2021 Background: Uveal melanoma is the most common primary intraocular malignancy in adults. In advanced cases, the prognosis is very poor. Thus far, no effective methods of pharmacotherapy of this cancer have been found.
Malgorzata Gajdzis +7 more
doaj +1 more source
SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress [PDF]
Open Biology, 2013 ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1, formerly PARP1) is localized in the nucleus, where it ADP-ribosylates specific target proteins. The post-translational modification (PTM) with a single ADP-ribose unit or with polymeric ADP-ribose ...
Ingrid Kassner +5 more
doaj +1 more source
Cooperative targeting of PARP-1 domains to regulate metabolic and developmental genes
Frontiers in Endocrinology, 2023 PARP-1, also known as poly(ADP-ribose) polymerase 1, is a multifunctional nuclear enzyme that plays a critical role in transcriptional regulation through its three functional domains: the N-terminal DNA-binding domain (DBD) containing two zinc fingers ...
Gbolahan Bamgbose +2 more
doaj +1 more source
Cells, 2020 Paracrine interactions between malignant estrogen receptor positive (ER+) breast cancer cells and breast adipose fibroblasts (BAFs) stimulate estrogen biosynthesis by aromatase in BAFs.
Alexander Kaiser +6 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Background: Since its discovery, poly (ADP-ribose) polymerase 1 (PARP-1) has been extensively studied due to its regulatory role in numerous biologically crucial pathways.
Wen-Hao Li +6 more
doaj +1 more source