PARP-1 couples β-catenin/TCF4 signaling to epithelial–mesenchymal transition in endometriosis [PDF]
Scientific ReportsEndometriosis exhibits epithelial–mesenchymal transition (EMT)-aligned traits that promote invasion and lesion persistence. We investigated whether poly(ADP-ribose) polymerase-1 (PARP-1) coordinates β-catenin/TCF4 activity with EMT programs and whether ...
Lu Zhang +6 more
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PARP-1 rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations [PDF]
Medeniyet Medical JournalObjective: Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme in DNA repair pathways and has been implicated in cancer susceptibility. The rs1136410 polymorphism in the PARP-1 gene has shown inconsistent associations with gastrointestinal cancer ...
Amirhosein NASERI +11 more
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Mono-methylated histones control PARP-1 in chromatin and transcription [PDF]
eLifePARP-1 is central to transcriptional regulation under both normal and stress conditions, with the governing mechanisms yet to be fully understood. Our biochemical and ChIP-seq-based analyses showed that PARP-1 binds specifically to active histone marks ...
Gbolahan Bamgbose +3 more
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Multi-stage structure-based virtual screening approach combining 3D pharmacophore, docking and molecular dynamic simulation towards the identification of potential selective PARP-1 inhibitors [PDF]
BMC ChemistryPresently, humanity is confronted with a range of diseases that have high death rates, especially those linked to cancerous growths. Several enzymes and proteins have been discovered as highly attractive targets for cancer treatment.
Mahmoud A. El Hassab +3 more
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Comment on “PARP-1 rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations” [PDF]
Medeniyet Medical JournalOnur ALKAN, Ismail NAZLI, Ahmet BASGOZE
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PARP-1 is a transcriptional rheostat of metabolic and bivalent genes during development [PDF]
Life Science AlliancePARP-1 fine-tunes gene expression to control energy balance and development by selectively repressing and activating critical genes for developmental progression. PARP-1 participates in various cellular processes, including gene regulation. In Drosophila
Gbolahan Bamgbose, Alexei Tulin
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Response to Letter to the Editor Regarding “PARP-1 rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations” [PDF]
Medeniyet Medical JournalAmirhosein NASERI +3 more
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The Prognostic Values of PARP-1 Expression in Uveal Melanoma
Cells, 2021 Background: Uveal melanoma is the most common primary intraocular malignancy in adults. In advanced cases, the prognosis is very poor. Thus far, no effective methods of pharmacotherapy of this cancer have been found.
Malgorzata Gajdzis +7 more
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Cooperative targeting of PARP-1 domains to regulate metabolic and developmental genes
Frontiers in Endocrinology, 2023 PARP-1, also known as poly(ADP-ribose) polymerase 1, is a multifunctional nuclear enzyme that plays a critical role in transcriptional regulation through its three functional domains: the N-terminal DNA-binding domain (DBD) containing two zinc fingers ...
Gbolahan Bamgbose +2 more
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Cells, 2020 Paracrine interactions between malignant estrogen receptor positive (ER+) breast cancer cells and breast adipose fibroblasts (BAFs) stimulate estrogen biosynthesis by aromatase in BAFs.
Alexander Kaiser +6 more
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