Results 1 to 10 of about 95,810 (120)

Resveratrol derivative production by high-pressure treatment: proliferative inhibitory effects on cervical cancer cells

Food & Nutrition Research, 2022
Background: In recent years, functional food components have attracted considerable attention. Resveratrol, a food polyphenol, has been widely studied due to its various physiological activities.
Yuki Sugahara, Toshiro Ohta, Yoshiki Taguchi, Wataru Kadowaki, Sari Honda, Yasuhiro Kashima, Taiji Matsukawa, Shigenori Kumazawa   +7 more
doaj   +1 more source

BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibiting homologous recombination repair

Cancer Biology & Medicine, 2022
Objective: We aimed to investigate the radiosensitizing efficacy of the poly-ADP-ribose polymerase (PARP) inhibitor, olaparib, and the Bloom syndrome protein (BLM) helicase inhibitor, ML216, in non-small cell lung cancer (NSCLC) cells.
Yangyang Kong, Chang Xu, Xiaohui Sun, Hao Sun, Xiaotong Zhao, Ningning He, Kaihua Ji, Qin Wang, Liqing Du, Jinhan Wang, Manman Zhang, Yang Liu, Yan Wang, Qiang Liu   +13 more
doaj   +1 more source

Approaches to PET Imaging of Glioblastoma

Molecules, 2020
Glioblastoma multiforme (GBM) is the deadliest type of brain tumor, affecting approximately three in 100,000 adults annually. Positron emission tomography (PET) imaging provides an important non-invasive method of measuring biochemically specific targets
Lindsey R. Drake, Ansel T. Hillmer, Zhengxin Cai   +2 more
doaj   +1 more source

Olaparib Combined with an ATR or Chk1 Inhibitor as a Treatment Strategy for Acquired Olaparib-Resistant BRCA1 Mutant Ovarian Cells

Diagnostics, 2020
Objective: Despite the promise of PARP inhibitors (PARPi) for treating BRCA1/2 mutated ovarian cancer (OC), drug resistance invariably develops. We hypothesized rationale drug combinations, targeting key molecules in DNA repair pathways and the cell ...
Brian T. Burgess, Abigail M. Anderson, J. Robert McCorkle, Jianrong Wu, Frederick R. Ueland, Jill M. Kolesar   +5 more
doaj   +1 more source

Revealing the selective mechanisms of inhibitors to PARP-1 and PARP-2 via multiple computational methods [PDF]

PeerJ, 2020
Background Research has shown that Poly-ADP-ribose polymerases 1 (PARP-1) is a potential therapeutic target in the clinical treatment of breast cancer.
Hongye Hu, Buran Chen, Danni Zheng, Guanli Huang   +3 more
doaj   +2 more sources

Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

eLife, 2021
Poly(ADP-ribose) polymerase 7 (PARP-7) has emerged as a critically important member of a large enzyme family that catalyzes ADP-ribosylation in mammalian cells. PARP-7 is a critical regulator of the innate immune response.
Kelsie M Rodriguez, Sara C Buch-Larsen, Ilsa T Kirby, Ivan Rodriguez Siordia, David Hutin, Marit Rasmussen, Denis M Grant, Larry L David, Jason Matthews, Michael L Nielsen, Michael S Cohen   +10 more
doaj   +1 more source

Cooperative targeting of PARP-1 domains to regulate metabolic and developmental genes

Frontiers in Endocrinology, 2023
PARP-1, also known as poly(ADP-ribose) polymerase 1, is a multifunctional nuclear enzyme that plays a critical role in transcriptional regulation through its three functional domains: the N-terminal DNA-binding domain (DBD) containing two zinc fingers ...
Gbolahan Bamgbose, Sarah Johnson, Alexei Tulin   +2 more
doaj   +1 more source

PARP-1: a critical regulator in radioprotection and radiotherapy-mechanisms, challenges, and therapeutic opportunities

Frontiers in Pharmacology, 2023
Background: Since its discovery, poly (ADP-ribose) polymerase 1 (PARP-1) has been extensively studied due to its regulatory role in numerous biologically crucial pathways.
Wen-Hao Li, Fei Wang, Gui-Yuan Song, Qing-Hua Yu, Rui-Peng Du, Ping Xu, Ping Xu   +6 more
doaj   +1 more source

Silencing of PARP2 Blocks Autophagic Degradation

Cells, 2020
Poly(ADP-Ribose) polymerases (PARPs) are enzymes that metabolize NAD+. PARP1 and PARP10 were previously implicated in the regulation of autophagy. Here we showed that cytosolic electron-dense particles appear in the cytoplasm of C2C12 myoblasts in which ...
Laura Jankó, Zsanett Sári, Tünde Kovács, Gréta Kis, Magdolna Szántó, Miklós Antal, Gábor Juhász, Péter Bai   +7 more
doaj   +1 more source

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source