Results 1 to 10 of about 166,230 (205)

PARP‐1 regulates DNA repair factor availability [PDF]

EMBO Molecular Medicine, 2018
PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP‐1 enzymatic
Matthew J Schiewer, Amy C Mandigo, Nicolas Gordon, Fangjin Huang, Sanchaika Gaur, Renée de Leeuw, Shuang G Zhao, Joseph Evans, Sumin Han, Theodore Parsons, Ruth Birbe, Peter McCue, Christopher McNair, Saswati N Chand, Ylenia Cendon‐Florez, Peter Gallagher, Jennifer J McCann, Neermala Poudel Neupane, Ayesha A Shafi, Emanuela Dylgjeri, Lucas J Brand, Tapio Visakorpi, Ganesh V Raj, Costas D Lallas, Edouard J Trabulsi, Leonard G Gomella, Adam P Dicker, Wm. Kevin Kelly, Benjamin E Leiby, Beatrice Knudsen, Felix Y Feng, Karen E Knudsen   +31 more
doaj   +3 more sources

PARP-1 couples β-catenin/TCF4 signaling to epithelial–mesenchymal transition in endometriosis [PDF]

Scientific Reports
Endometriosis exhibits epithelial–mesenchymal transition (EMT)-aligned traits that promote invasion and lesion persistence. We investigated whether poly(ADP-ribose) polymerase-1 (PARP-1) coordinates β-catenin/TCF4 activity with EMT programs and whether ...
Lu Zhang, Xianli Li, Liang Kong, Xiaoying Hou, Bohan Li, Ying Zhang, Jinjuan Wang   +6 more
doaj   +2 more sources

PARP inhibitors [PDF]

Hereditary Cancer in Clinical Practice, 2015
بوليميرازات بولي (ADP - ريبوز)، التي يتم اختصارها باسم PARPs، هي مجموعة من البروتينات المألوفة التي تلعب دورًا مركزيًا في إصلاح الحمض النووي باستخدام مسار إصلاح استئصال القاعدة (BER). هناك حوالي 17 بروتينًا في هذه العائلة منها PARPs النووية الأولية هي PARP -1 و PARP -2 و PARP -3 و tankyrases 1 و 2 (PARP -5a و -5b).
Maheen Anwar, Hafiz Muhammad Aslam, Shahzad Anwar   +2 more
  +6 more sources

Resveratrol derivative production by high-pressure treatment: proliferative inhibitory effects on cervical cancer cells

Food & Nutrition Research, 2022
Background: In recent years, functional food components have attracted considerable attention. Resveratrol, a food polyphenol, has been widely studied due to its various physiological activities.
Yuki Sugahara, Toshiro Ohta, Yoshiki Taguchi, Wataru Kadowaki, Sari Honda, Yasuhiro Kashima, Taiji Matsukawa, Shigenori Kumazawa   +7 more
doaj   +1 more source

BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibiting homologous recombination repair

Cancer Biology & Medicine, 2022
Objective: We aimed to investigate the radiosensitizing efficacy of the poly-ADP-ribose polymerase (PARP) inhibitor, olaparib, and the Bloom syndrome protein (BLM) helicase inhibitor, ML216, in non-small cell lung cancer (NSCLC) cells.
Yangyang Kong, Chang Xu, Xiaohui Sun, Hao Sun, Xiaotong Zhao, Ningning He, Kaihua Ji, Qin Wang, Liqing Du, Jinhan Wang, Manman Zhang, Yang Liu, Yan Wang, Qiang Liu   +13 more
doaj   +1 more source

Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies [PDF]

Cancers, 2020
Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 are enzymes which post-translationally modify proteins through poly(ADP-ribosyl)ation (PARylation)—the transfer of ADP-ribose chains onto amino acid residues—with a resultant modulation of protein function.
Yélamos López, José, Lama, Lucía, 1993-, Jimeno, Jaime, Ali, Syed O.   +3 more
openaire   +3 more sources

Poly(ADP-ribose)polymerase activity controls plant growth by promoting leaf cell number [PDF]

, 2014
A changing global environment, rising population and increasing demand for biofuels are challenging agriculture and creating a need for technologies to increase biomass production.
Claeys, Hannes, Degenkolbe, Thomas, Hannah, Matthew A, Jansseune, Karel, Méret, Michaël, Schulz, Philipp, Skirycz, Aleksandra, Teige, Markus, Willmitzer, Lothar   +8 more
core   +10 more sources

Approaches to PET Imaging of Glioblastoma

Molecules, 2020
Glioblastoma multiforme (GBM) is the deadliest type of brain tumor, affecting approximately three in 100,000 adults annually. Positron emission tomography (PET) imaging provides an important non-invasive method of measuring biochemically specific targets
Lindsey R. Drake, Ansel T. Hillmer, Zhengxin Cai   +2 more
doaj   +1 more source

Olaparib Combined with an ATR or Chk1 Inhibitor as a Treatment Strategy for Acquired Olaparib-Resistant BRCA1 Mutant Ovarian Cells

Diagnostics, 2020
Objective: Despite the promise of PARP inhibitors (PARPi) for treating BRCA1/2 mutated ovarian cancer (OC), drug resistance invariably develops. We hypothesized rationale drug combinations, targeting key molecules in DNA repair pathways and the cell ...
Brian T. Burgess, Abigail M. Anderson, J. Robert McCorkle, Jianrong Wu, Frederick R. Ueland, Jill M. Kolesar   +5 more
doaj   +1 more source

Revealing the selective mechanisms of inhibitors to PARP-1 and PARP-2 via multiple computational methods [PDF]

PeerJ, 2020
Background Research has shown that Poly-ADP-ribose polymerases 1 (PARP-1) is a potential therapeutic target in the clinical treatment of breast cancer.
Hongye Hu, Buran Chen, Danni Zheng, Guanli Huang   +3 more
doaj   +2 more sources