Results 31 to 40 of about 96,094 (164)
Cell, 2010 Cells possess internal ∼24 hr or circadian clocks that synchronize physiological processes with daily cycles of light and nutrient availability. In this issue, Asher et al. (2010) find that PARP-1 (poly(ADP-ribose) polymerase 1) modifies components of the clock machinery in response to feeding, providing a mechanism for how metabolic rhythms coordinate
Kumar, Vivek, Takahashi, Joseph S.
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Neurobiology of Disease, 2023 Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member of the PARP superfamily, with its primary function being the facilitation of DNA damage repair processes.
Xiaoxue Xu, Bowen Sun, Chuansheng Zhao
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Journal of the Turkish German Gynecological Association, 2015 Polyadenosine diphosphate (ADP) ribose polymerase (PARP) lends a panoramic view to the inner mystery of protection of integrity of deoxyribonucleic acid (DNA) in a cell genome. They are a balancing part of an even more dynamic equilibrium of normalcy against daily assaults.
Chinmoy K, Bose, Nirban, Basu
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Stem Cell Research, 2017 Poly (ADP-ribose) polymerase (PARP) family members are ubiquitously expressed and play a key role in cellular processes, including DNA repair and cell death/survival balance. Accordingly, PARP inhibition is an emerging pharmacological strategy for cancer
Vito A. Baldassarro +3 more
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Clinical relevance of endoscopic peri-appendiceal red patch in ulcerative colitis patients
Therapeutic Advances in Gastroenterology, 2022 Background: Increasing evidence is suggesting appendectomy as an alternative treatment for ulcerative colitis (UC), especially in case of histological appendiceal inflammation.
Maud A. Reijntjes +5 more
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eLife, 2021 PARP-7 (TiPARP) is a mono(ADP-ribosyl) transferase whose protein substrates and biological activities are poorly understood. We observed that PARP7 mRNA levels are lower in ovarian cancer patient samples compared to non-cancerous tissue, but PARP-7 ...
Lavanya H Palavalli Parsons +7 more
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Drug Design, Development and Therapy, 2020 Yanshu Li, 1–3 Shiheng Jia, 3, 4 Wei Dai 5, 6 1Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, Liaoning, People’s Republic of China; 2Key Laboratory of Medical Cell Biology, Ministry of ...
Li Y, Jia S, Dai W
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Spontaneous Development of Dental Dysplasia in Aged Parp-1 Knockout Mice
Cells, 2019 Poly(ADP-ribose) polymerase (Parp)-1 catalyzes polyADP-ribosylation using NAD+ and is involved in the DNA damage response, genome stability, and transcription.
Hisako Fujihara +6 more
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Bioscience Reports, 2022 Abstract Post-translational modifications exist in different varieties to regulate diverse characteristics of their substrates, ultimately leading to maintenance of cell health. The enzymes of the intracellular poly(ADP-ribose) polymerase (PARP) family can transfer either a single ADP-ribose to targets, in a reaction called mono(ADP ...
Karla L.H. Feijs, Roko Žaja
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Cancer Management and Research, 2020 Linggang Zhu,1,2 Chu Zhu,1 Xuanxuan Wang,1 Hai Liu,1 Yanhong Zhu,1 Xiaonan Sun1 1Department of Radiation Oncology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2Department of Radiation ...
Zhu L +5 more
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