Results 41 to 50 of about 96,094 (164)
PARP-14 binds specific DNA sequences to promote Th2 cell gene expression. [PDF]
PLoS ONE, 2013 PARP-14, a member of the poly ADP-ribose polymerase super family, promotes T helper cell 2 (Th2) differentiation by regulating interleukin-4 (IL-4) and STAT6-dependent transcription.
Jonathan P Riley +6 more
doaj +1 more source
Mediprintic sp. z o.o.'s 3D printed forearm orthosis project stakeholder analysis.
Journal of Modern ScienceObjectives: The purpose of the research was to perform a stakeholder analysis for the Research and Development project of Mediprintic sp. z o.o. in order to confirm correctly identified parties for cooperation within the 1.1.2 PARP Start-up Platforms ...
Andrzej Zakręcki, Piotr Zawada
doaj +1 more source
PARP‐1 regulates DNA repair factor availability
EMBO Molecular Medicine, 2018 PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP‐1 enzymatic
Matthew J Schiewer +31 more
doaj +1 more source
PARP-1 modulates amyloid beta peptide-induced neuronal damage. [PDF]
PLoS ONE, 2013 Amyloid beta peptide (Aβ) causes neurodegeneration by several mechanisms including oxidative stress, which is known to induce DNA damage with the consequent activation of poly (ADP-ribose) polymerase (PARP-1).
Sara Martire +14 more
doaj +1 more source
Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery
BMC Cell Biology, 2003 Background The cytotoxicity and the rejoining of DNA double-strand breaks induced by γ-rays, H2O2 and neocarzinostatin, were investigated in normal and PARP-1 knockout mouse 3T3 fibroblasts to determine the role of poly(ADP-ribose) polymerase (PARP-1) in
Fernet Marie +4 more
doaj +1 more source
PARPs and PARP inhibitors: molecular mechanisms and clinical applications
Molecular BiomedicineAbstract Poly (ADP-ribose) polymerases (PARPs) are a diverse family of enzymes that regulate genome stability, cell death, and stress responses through ADP-ribosylation. Among them, PARP1, PARP2, and PARP3 are central to cellular DNA repair, while tankyrases, and their isoforms, contribute to telomere maintenance, transcriptional ...
Fei Wang +3 more
openaire +2 more sources
Differential Localisation of PARP-1 N-Terminal Fragment in PARP-1+/+ and PARP-1−/− Murine Cells
Molecules and Cells, 2014 Human PARP family consists of 17 members of which PARP-1 is a prominent member and plays a key role in DNA repair pathways. It has an N-terminal DNA-binding domain (DBD) encompassing the nuclear localisation signal (NLS), central automodification domain and C-terminal catalytic domain. PARP-1 accounts for majority of poly-(ADP-ribose) polymer synthesis
Ida Rachel, Rajiah, Jeremy, Skepper
openaire +3 more sources
Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment
Neural Plasticity, 2019 Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that regulates gene expression through poly(ADP)-ribosylation, resulting in the loosening of chromatin structure.
Matthew Regier +5 more
doaj +1 more source
Poly(ADP-ribose) Polymerase-1 in the Nervous System
Neurobiology of Disease, 2000 Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme, activated by DNA strand breaks to participate in DNA repair. Overactivation of PARP by cellular insults depletes its substrate NAD+ and then ATP, leading to a major energy deficit and cell death.
Hyo Chol Ha, Solomon H. Snyder
doaj +1 more source
Tumor Biology, 2017 PARP-1 (poly(ADP-ribose) polymerase-1) plays an important role in tumorigenesis. Since its effects on different populations are varied, this study investigated the impact of PARP-1 on primary hepatocellular carcinoma in a Southern Chinese Zhuang ...
Jiatong Li +14 more
doaj +1 more source